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Showing 1 to 12 of 401 entries
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Development of a peptide by phage display for SPECT imaging of resistance-susceptible breast cancer.

American journal of nuclear medicine and molecular imaging

Larimer BM, Deutscher SL.
PMID: 25143862
Am J Nucl Med Mol Imaging. 2014 Aug 15;4(5):435-47. eCollection 2014.

Personalized medicine is at the forefront of cancer diagnosis and therapy. Molecularly targeted therapies such as trastuzumab and tamoxifen have enhanced prognosis of patients with cancers expressing ERBB2 and the estrogen receptor, respectively. One obstacle to targeted therapy is...

Radionuclide bone scan SPECT-CT: lowering the dose of CT significantly reduces radiation dose without impacting CT image quality.

American journal of nuclear medicine and molecular imaging

Gupta SK, Trethewey S, Brooker B, Rutherford N, Diffey J, Viswanathan S, Attia J.
PMID: 28533938
Am J Nucl Med Mol Imaging. 2017 Apr 15;7(2):63-73. eCollection 2017.

The CT component of SPECT-CT is required for attenuation correction and anatomical localization of the uptake on SPECT but there is no guideline about the optimal CT acquisition parameters. In our department, a standard CT acquisition protocol was changed...

Prediction of positron emission tomography/computed tomography (PET/CT) positivity in patients with high-risk primary melanoma.

American journal of nuclear medicine and molecular imaging

Danielsen M, Kjaer A, Wu M, Martineau L, Nosrati M, Leong SP, Sagebiel RW, Miller JR, Kashani-Sabet M.
PMID: 27766186
Am J Nucl Med Mol Imaging. 2016 Sep 22;6(5):277-285. eCollection 2016.

Positron emission tomography/computed tomography (PET/CT) is an important tool to identify occult melanoma metastasis. To date, it is controversial which patients with primary cutaneous melanoma should have staging PET/CT. In this retrospective analysis of more than 800 consecutive patients...

Absorbed radiation dosimetry of the D.

American journal of nuclear medicine and molecular imaging

Laforest R, Karimi M, Moerlein SM, Xu J, Flores HP, Bognar C, Li A, Mach RH, Perlmutter JS, Tu Z.
PMID: 28078183
Am J Nucl Med Mol Imaging. 2016 Nov 30;6(6):301-309. eCollection 2016.

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Precision medicine and molecular imaging: new targeted approaches toward cancer therapeutic and diagnosis.

American journal of nuclear medicine and molecular imaging

Ghasemi M, Nabipour I, Omrani A, Alipour Z, Assadi M.
PMID: 28078184
Am J Nucl Med Mol Imaging. 2016 Nov 30;6(6):310-327. eCollection 2016.

This paper presents a review of the importance and role of precision medicine and molecular imaging technologies in cancer diagnosis with therapeutics and diagnostics purposes. Precision medicine is progressively becoming a hot topic in all disciplines related to biomedical...

The next evolution in radioguided surgery: breast cancer related sentinel node localization using a freehandSPECT-mobile gamma camera combination.

American journal of nuclear medicine and molecular imaging

Engelen T, Winkel BM, Rietbergen DD, KleinJan GH, Vidal-Sicart S, Olmos RA, van den Berg NS, van Leeuwen FW.
PMID: 26069857
Am J Nucl Med Mol Imaging. 2015 Feb 15;5(3):233-45. eCollection 2015.

Accurate pre- and intraoperative identification of the sentinel node (SN) forms the basis of the SN biopsy procedure. Gamma tracing technologies such as a gamma probe (GP), a 2D mobile gamma camera (MGC) or 3D freehandSPECT (FHS) can be...

In vivo inflammation imaging using a CB2R-targeted near infrared fluorescent probe.

American journal of nuclear medicine and molecular imaging

Zhang S, Shao P, Ling X, Yang L, Hou W, Thorne SH, Beaino W, Anderson CJ, Ding Y, Bai M.
PMID: 26069858
Am J Nucl Med Mol Imaging. 2015 Feb 15;5(3):246-58. eCollection 2015.

Chronic inflammation is considered as a critical cause of a host of disorders, such as cancer, rheumatoid arthritis, atherosclerosis, and neurodegenerative diseases, although the exact mechanism is yet to be explored. Imaging tools that can specifically target inflammation are...

Probabilistic atlas-based segmentation of combined T1-weighted and DUTE MRI for calculation of head attenuation maps in integrated PET/MRI scanners.

American journal of nuclear medicine and molecular imaging

Poynton CB, Chen KT, Chonde DB, Izquierdo-Garcia D, Gollub RL, Gerstner ER, Batchelor TT, Catana C.
PMID: 24753982
Am J Nucl Med Mol Imaging. 2014 Mar 20;4(2):160-71. eCollection 2014.

We present a new MRI-based attenuation correction (AC) approach for integrated PET/MRI systems that combines both segmentation- and atlas-based methods by incorporating dual-echo ultra-short echo-time (DUTE) and T1-weighted (T1w) MRI data and a probabilistic atlas. Segmented atlases were constructed...

Multi-radionuclide digital autoradiography of the intra-aortic atherosclerotic plaques using a monoclonal antibody targeting oxidized low-density lipoprotein.

American journal of nuclear medicine and molecular imaging

Orbom A, Jansson B, Schiopu A, Evans-Axelsson S, Nilsson J, Fredrikson GN, Strand SE.
PMID: 24753983
Am J Nucl Med Mol Imaging. 2014 Mar 20;4(2):172-80. eCollection 2014.

The aim of this study was to use multi-radionuclide autoradiography to compare the different distributions of three radiolabelled tracers in an atherosclerotic mouse model. This method, along with immunohistochemistry, was applied to investigate the intra-aortic distribution of 2-deoxy-2-[(18)F]fluoro-D-glucose ((18)F-FDG),...

Modeling and imaging cardiac sympathetic neurodegeneration in Parkinson's disease.

American journal of nuclear medicine and molecular imaging

Joers V, Emborg ME.
PMID: 24753981
Am J Nucl Med Mol Imaging. 2014 Mar 20;4(2):125-59. eCollection 2014.

Parkinson's disease (PD) is currently recognized as a multisystem disorder affecting several components of the central and peripheral nervous system. This new understanding of PD helps explain the complexity of the patients' symptoms while challenges researchers to identify new...

Phase I trial to evaluate the tumor and normal tissue uptake, radiation dosimetry and safety of (111)In-DTPA-human epidermal growth factor in patients with metastatic EGFR-positive breast cancer.

American journal of nuclear medicine and molecular imaging

Vallis KA, Reilly RM, Scollard D, Merante P, Brade A, Velauthapillai S, Caldwell C, Chan I, Freeman M, Lockwood G, Miller NA, Cornelissen B, Petronis J, Sabate K.
PMID: 24753984
Am J Nucl Med Mol Imaging. 2014 Mar 20;4(2):181-92. eCollection 2014.

The safety, pharmacokinetics, biodistribution and radiation dosimetry of (111)In-DTPA-hEGF, an Auger electron-emitting radiopharmaceutical, were evaluated in a first-in-human trial. Dose escalation was performed in patients with EGFR-positive metastatic breast cancer who had received ≥2 prior courses of systemic treatment....

Cognitive reserve and clinical expression of Alzheimer's disease: evidence and implications for brain PET imaging.

American journal of nuclear medicine and molecular imaging

Morbelli S, Nobili F.
PMID: 24795838
Am J Nucl Med Mol Imaging. 2014 Apr 25;4(3):239-47. eCollection 2014.

Cognitive reserve (CR) refers to the hypothesized capacity of an adult brain to cope with brain damage in order to minimize symptomatology. The present review is focused on the contribution of brain PET in the understanding of the influence...

Showing 1 to 12 of 401 entries