Advanced Search
Display options
Filter resources
Text Availability
Article type
Publication date
Species
Language
Sex
Age
Showing 1 to 12 of 56 entries
Sorted by: Best Match Show Resources per page
Alfred Hildebrandt: from basic research to clinical application and drug regulation.

Drug metabolism reviews

Greim H.
PMID: 10335436
Drug Metab Rev. 1999 May;31(2):309-15. doi: 10.1081/dmr-100101919.

No abstract available.

19th North American ISSX and 29th JSSX Meeting 19-23 October 2014 San Francisco, California, USA.

Drug metabolism reviews

[No authors listed]
PMID: 26247905
Drug Metab Rev. 2015;47:2-3. doi: 10.3109/03602532.2015.1071935. Epub 2015 Oct 02.

No abstract available.

What dominates the changeable pharmacokinetics of natural sesquiterpene lactones and diterpene lactones: a review focusing on absorption and metabolism.

Drug metabolism reviews

Yu Z, Chen Z, Li Q, Yang K, Huang Z, Wang W, Zhao S, Hu H.
PMID: 33211987
Drug Metab Rev. 2021 Feb;53(1):122-140. doi: 10.1080/03602532.2020.1853151. Epub 2020 Dec 21.

Sesquiterpene lactones (STLs) and diterpene lactones (DTLs) are two groups of common phytochemicals with similar structures. It's frequently reported that both exhibit changeable pharmacokinetics (PK)

Moonlighting in drug metabolism.

Drug metabolism reviews

Board PG, Anders MW.
PMID: 33264039
Drug Metab Rev. 2021 Feb;53(1):76-99. doi: 10.1080/03602532.2020.1858857. Epub 2020 Dec 28.

Drug metabolizing enzymes catalyze the biotransformation of many of drugs and chemicals. The drug metabolizing enzymes are distributed among several evolutionary families and catalyze a range of detoxication reactions, including oxidation/reduction, conjugative, and hydrolytic reactions that serve to detoxify...

Pharmacokinetics, toxicological and clinical aspects of ulipristal acetate: insights into the mechanisms implicated in the hepatic toxicity.

Drug metabolism reviews

Dinis-Oliveira RJ.
PMID: 33905271
Drug Metab Rev. 2021 Aug;53(3):375-383. doi: 10.1080/03602532.2021.1917599. Epub 2021 Apr 27.

Ulipristal acetate is a drug used as emergency contraceptive (30 mg) and for the treatment of moderate to severe symptoms of uterine myomas (5 mg). After commercialization, and although the exact number is unknown, serious cases implying ulipristal acetate...

Transporter-mediated drug-drug interactions: advancement in models, analytical tools, and regulatory perspective.

Drug metabolism reviews

Jala A, Ponneganti S, Vishnubhatla DS, Bhuvanam G, Mekala PR, Varghese B, Radhakrishnanand P, Adela R, Murty US, Borkar RM.
PMID: 33980079
Drug Metab Rev. 2021 Aug;53(3):285-320. doi: 10.1080/03602532.2021.1928687. Epub 2021 Jun 02.

Drug-drug interactions mediated by transporters are a serious clinical concern hence a tremendous amount of work has been done on the characterization of the transporter-mediated proteins in humans and animals. The underlying mechanism for the transporter-mediated drug-drug interaction is...

Recent developments in .

Drug metabolism reviews

Yadav J, El Hassani M, Sodhi J, Lauschke VM, Hartman JH, Russell LE.
PMID: 33989099
Drug Metab Rev. 2021 May;53(2):207-233. doi: 10.1080/03602532.2021.1922435. Epub 2021 May 25.

Improved pharmacokinetics/pharmacodynamics (PK/PD) prediction in the early stages of drug development is essential to inform lead optimization strategies and reduce attrition rates. Recently, there have been significant advancements in the development of new

Pharmacology of apocynin: a natural acetophenone.

Drug metabolism reviews

Savla SR, Laddha AP, Kulkarni YA.
PMID: 33689526
Drug Metab Rev. 2021 Nov;53(4):542-562. doi: 10.1080/03602532.2021.1895203. Epub 2021 Mar 10.

Apocynin is a naturally occurring acetophenone, found in the roots of

In memoriam Dr. Frederick J. Di Carlo, executive editor, Drug Metabolism Reviews, 1970-1997.

Drug metabolism reviews

Israili ZH.
PMID: 9421678
Drug Metab Rev. 1997 Nov;29(4):v-xi. doi: 10.3109/03602539709002235.

No abstract available.

Bioanalytical strategies in drug discovery and development.

Drug metabolism reviews

Thakur A, Tan Z, Kameyama T, El-Khateeb E, Nagpal S, Malone S, Jamwal R, Nwabufo CK.
PMID: 34310243
Drug Metab Rev. 2021 Aug;53(3):434-458. doi: 10.1080/03602532.2021.1959606. Epub 2021 Aug 23.

A reliable, rapid, and effective bioanalytical method is essential for the determination of the pharmacokinetic, pharmacodynamic, and toxicokinetic parameters that inform the safety and efficacy profile of investigational drugs. The overall goal of bioanalytical method development is to elucidate...

Toxicogenomics of drug induced liver injury - from mechanistic understanding to early prediction.

Drug metabolism reviews

Lauschke VM.
PMID: 33683927
Drug Metab Rev. 2021 May;53(2):245-252. doi: 10.1080/03602532.2021.1894571. Epub 2021 Mar 08.

Despite rigorous preclinical testing, clinical attrition rates in drug development remain high with drug-induced liver injury (DILI) remaining one of the most frequent causes of project failures. To understand DILI mechanisms, major efforts are put into the development of...

Janus nanoparticles: an efficient intelligent modern nanostructure for eradicating cancer.

Drug metabolism reviews

Gheisari F, Shafiee M, Abbasi M, Jangjou A, Izadpanah P, Vaez A, Amani AM.
PMID: 33561356
Drug Metab Rev. 2021 Nov;53(4):592-603. doi: 10.1080/03602532.2021.1878530. Epub 2021 Feb 09.

In the modern age, the struggle to generate appropriate bio-based materials and nano-scaled colloidal particulates for developed application domains, has already resulted in remarkable attempts in the advancement of regulated size and shape, anisotropy, and characteristics of nanostructures. The...

Showing 1 to 12 of 56 entries