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Showing 1 to 12 of 508 entries
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Persistent Corneal Epithelial Defects: A Review Article.

Medical hypothesis, discovery & innovation ophthalmology journal

Vaidyanathan U, Hopping GC, Liu HY, Somani AN, Ronquillo YC, Hoopes PC, Moshirfar M.
PMID: 31598519
Med Hypothesis Discov Innov Ophthalmol. 2019;8(3):163-176.

Persistent corneal epithelial defects (PEDs or PCEDs) result from the failure of rapid re-epithelialization and closure within 10-14 days after a corneal injury, even with standard supportive treatment. Disruptions in the protective epithelial and stromal layers of the cornea...

High-intensity interval training-induced hypertrophy in gastrocnemius muscle via improved IGF-I/Akt/FoxO and myostatin/Smad signaling pathways in rats.

Physiology international

Biglari S, Afousi AG, Mafi F, Shabkhiz F.
PMID: 32644938
Physiol Int. 2020 Jul 07; doi: 10.1556/2060.2020.00020. Epub 2020 Jul 07.

OBJECTIVE: It has been shown that high-intensity interval training (HIIT) leads to skeletal muscle hypertrophy; however, its mechanisms of cellular and molecular regulation are still unclear. The purpose of this study was to investigate the effect of HIIT on...

Evaluation of the Efficacy and Safety of Switching to Pasireotide in Patients With Acromegaly Inadequately Controlled With First-Generation Somatostatin Analogs.

Frontiers in endocrinology

Gadelha M, Bex M, Colao A, Pedroza García EM, Poiana C, Jimenez-Sanchez M, Yener S, Mukherjee R, Bartalotta A, Maamari R, Raverot G.
PMID: 32117045
Front Endocrinol (Lausanne). 2020 Feb 03;10:931. doi: 10.3389/fendo.2019.00931. eCollection 2019.

No abstract available.

Phase 2 Randomized, Placebo-Controlled Clinical Trial of Recombinant Human Growth Hormone (rhGH) During Rehabilitation From Traumatic Brain Injury.

Frontiers in endocrinology

Dubiel R, Callender L, Dunklin C, Harper C, Bennett M, Kreber L, Auchus R, Diaz-Arrastia R.
PMID: 30250451
Front Endocrinol (Lausanne). 2018 Sep 10;9:520. doi: 10.3389/fendo.2018.00520. eCollection 2018.

Traumatic brain injury (TBI) is a major cause of death and disability, but there are currently no therapies with proven efficacy for optimizing regeneration of repair during rehabilitation. Using standard stimulation tests, as many as 40-50% of survivors of...

The Effect of Insulin Like Growth Factor-1 on Recovery of Facial Nerve Crush Injury.

Clinical and experimental otorhinolaryngology

Bayrak AF, Olgun Y, Ozbakan A, Aktas S, Kulan CA, Kamaci G, Demir E, Yilmaz O, Olgun L.
PMID: 28264555
Clin Exp Otorhinolaryngol. 2017 Dec;10(4):296-302. doi: 10.21053/ceo.2016.00997. Epub 2017 Mar 08.

OBJECTIVES: The aim of this study is to investigate the efficacy of locally applied insulin-like growth factor 1 (IGF-1) on the recovery of facial nerve functions after crush injury in a rabbit model.METHODS: The rabbits were randomly assigned into...

Regulation of Insulin and Insulin-Like Activity in Malnourished Patients with Carcinoma Ventriculi Subjected to Total Gastrectomy and Personalized Nutritional Support.

Journal of medical biochemistry

Nedić O, Miljuš G, Malenković V.
PMID: 28356860
J Med Biochem. 2016 Jan;35(1):17-25. doi: 10.1515/jomb-2015-0013. Epub 2015 Dec 30.

BACKGROUND: Insulin and insulin-like growth factor (IGF) activities are disturbed during critical illness. Time-course changes in the concentrations of insulin, IGF-I and IGF-binding proteins (IGFBPs) were monitored in this study and their correlation with interleukin (IL)-6 was assessed in...

Insulin-like growth factor-II: new roles for an old actor.

Frontiers in endocrinology

Cianfarani S.
PMID: 23060858
Front Endocrinol (Lausanne). 2012 Oct 02;3:118. doi: 10.3389/fendo.2012.00118. eCollection 2012.

Insulin-like growth factor-II (IGF-II), traditionally considered as a growth factor implicated in growth of fetal tissues and cancer cells, is now emerging as a potential metabolic regulator. The aim of this overview is to provide the available evidence, obtained...

Mechanistic Target of Rapamycin Complex 1 Signaling Links Hypoxia to Increased IGFBP-1 Phosphorylation in Primary Human Decidualized Endometrial Stromal Cells.


Nandi P, Jang CE, Biggar K, Halari CD, Jansson T, Gupta MB.
PMID: 34572595
Biomolecules. 2021 Sep 18;11(9). doi: 10.3390/biom11091382.

Insulin-like growth factor-1 (IGF-1) bioavailability in pregnancy is governed by IGF binding protein (IGFBP-1) and its phosphorylation, which enhances the affinity of IGFBP-1 for the growth factor. The decidua is the predominant source of maternal IGFBP-1; however, the mechanisms...

Association between Serum Insulin-Like Growth Factor-1 and Neurological Severity in Acute Ischemic Stroke.

Journal of clinical neurology (Seoul, Korea)

Lee J, Lee J, Lee M, Lim JS, Kim JH, Yu KH, Oh MS, Lee BC.
PMID: 33835740
J Clin Neurol. 2021 Apr;17(2):206-212. doi: 10.3988/jcn.2021.17.2.206.

BACKGROUND AND PURPOSE: Serum insulin-like growth factor-1 (IGF-1) is known to have a neuroprotective effect. This study aimed to determine the effects of serum IGF-1 on the severity and clinical outcome of acute ischemic stroke (AIS).METHODS: This study included...

Metformin: A Potential Candidate for Targeting Aging Mechanisms.

Aging and disease

Hu D, Xie F, Xiao Y, Lu C, Zhong J, Huang D, Chen J, Wei J, Jiang Y, Zhong T.
PMID: 33815878
Aging Dis. 2021 Apr 01;12(2):480-493. doi: 10.14336/AD.2020.0702. eCollection 2021 Apr.

Aging is a universal phenomenon in all biological organisms, defined by the loss of reproductive capacity and a progressive decline in fitness. In humans, aging is further associated with an increased incidence of disease conditions. The current aging population...

Acromegaly with Normal Insulin-Like Growth Factor-1 Levels and Congestive Heart Failure as the First Clinical Manifestation.

Endocrinology and metabolism (Seoul, Korea)

Lee HM, Lee SH, Yang IH, Hwang IK, Hwang YC, Ahn KJ, Chung HY, Hwang HJ, Jeong IK.
PMID: 25491785
Endocrinol Metab (Seoul). 2015 Sep;30(3):395-401. doi: 10.3803/EnM.2015.30.3.395. Epub 2015 Sep 22.

The leading cause of morbidity and mortality in patients with acromegaly is cardiovascular complications. Myocardial exposure to excessive growth hormone can cause ventricular hypertrophy, hypertension, arrhythmia, and diastolic dysfunction. However, congestive heart failure as a result of systolic dysfunction...

Relationship between serum insulin-like growth factor-1, IGF binding protein-3 levels and body height before and after gonadotropin-releasing hormone agonist therapy.

Annals of pediatric endocrinology & metabolism

Song HS, Choi WB, Song JS, Hwang IT, Yang S.
PMID: 25654067
Ann Pediatr Endocrinol Metab. 2014 Dec;19(4):208-13. doi: 10.6065/apem.2014.19.4.208. Epub 2014 Dec 31.

PURPOSE: The gonadotropin-releasing hormone agonist (GnRHa) is widely used to treat patients with precocious puberty. However, its effect on growth is often difficult to predict because of the diverse nature of its causes and presentation. This study aims to...

Showing 1 to 12 of 508 entries