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Showing 1 to 12 of 2012 entries
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The journal of medical, chemical, biological, and radiological defense

Lockridge O, Schopfer LM, Winger G, Woods JH.
PMID: 16788731
J Med Chem Biol Radiol Def. 2005 Jul 01;3:nihms5095. doi: 10.1901/jaba.2005.3-nihms5095.

Pretreatment of animals with butyrylcholinesterase (EC BChE) provides complete protection from the acute effects of organophosphorus nerve agents. Butyrylcholinesterase has also been shown to protect from cocaine toxicity. Large amounts of highly purified butyrylcholinesterase are needed to test...

Design of Novel Amphipathic α-Helical Antimicrobial Peptides with No Toxicity as Therapeutics against the Antibiotic-Resistant Gram-Negative Bacterial Pathogen, .

Journal of medicinal chemistry and drug design

Mant CT, Jiang Z, Gera L, Davis T, Hodges RS.
PMID: 34377965
J Med Chem Drug Des. 2019;2(2). Epub 2019 May 30.

We designed

Research on heterocyclic compounds, XLI. 2-Phenylimidazo.

European journal of medicinal chemistry

Sacchi A, Laneri S, Arena F, Abignente E, Gallitelli M, D'amico M, Filippelli W, Rossi F.
PMID: 10889324
Eur J Med Chem. 1999 Nov 01;34(11):1003-1008. doi: 10.1016/s0223-5234(99)00112-9.

The synthesis of a group of 2-phenylimidazo[1,2-b]pyridazine-3-acetic esters and acids is described. The structures of the new compounds are supported by 1H-NMR spectra. These compounds were tested in vivo for their anti-inflammatory, analgesic and ulcerogenic activity. All new compounds...

Synthesis, Characterization, and Antimicrobial Activity of a Novel Trisazo Dye from 3-Amino-4H-thieno[3,4-c][1]benzopyran-4-one.

International journal of medicinal chemistry

Tsemeugne J, Sopbué Fondjo E, Tamokou JD, Rohand T, Ngongang AD, Kuiate JR, Sondengam BL.
PMID: 29484208
Int J Med Chem. 2018 Feb 01;2018:9197821. doi: 10.1155/2018/9197821. eCollection 2018.

A new trisazo dye has been synthesized by coupling the diazonium ion of 3-amino-4H thieno[3,4-c][1]benzopyran-4-one with 2-

Inhibition of RNA Helicases of ssRNA(+) Virus Belonging to Flaviviridae, Coronaviridae and Picornaviridae Families.

International journal of medicinal chemistry

Briguglio I, Piras S, Corona P, Carta A.
PMID: 27516903
Int J Med Chem. 2011;2011:213135. doi: 10.1155/2011/213135. Epub 2010 Nov 14.

Many viral pathogens encode the motor proteins named RNA helicases which display various functions in genome replication. General strategies to design specific and selective drugs targeting helicase for the treatment of viral infections could act via one or more...

Studies on 16α-Hydroxylation of Steroid Molecules and Regioselective Binding Mode in Homology-Modeled Cytochrome P450-2C11.

International journal of medicinal chemistry

Ali HI, Yamada M, Fujita Y, Maeda M, Akaho E.
PMID: 27516905
Int J Med Chem. 2011;2011:918168. doi: 10.1155/2011/918168. Epub 2010 Jul 27.

We investigated the 16α-hydroxylation of steroid molecules and regioselective binding mode in homology-modeled cytochrome P450-2C11 to correlate the biological study with the computational molecular modeling. It revealed that there was a positive relationship between the observed inhibitory potencies and...

Targeting Peroxisome Proliferator-Activated Receptors Using Thiazolidinediones: Strategy for Design of Novel Antidiabetic Drugs.

International journal of medicinal chemistry

Thangavel N, Al Bratty M, Akhtar Javed S, Ahsan W, Alhazmi HA.
PMID: 28656106
Int J Med Chem. 2017;2017:1069718. doi: 10.1155/2017/1069718. Epub 2017 Jun 05.

Thiazolidinediones are a class of well-established antidiabetic drugs, also named as glitazones. Thiazolidinedione structure has been an important structural domain of research, involving design and development of new drugs for the treatment of type 2 diabetes. Extensive research on...

A new bioconcentration factor model based on SMILES and indices of presence of atoms.

European journal of medicinal chemistry

Toropova AP, Toropov AA, Lombardo A, Roncaglioni A, Benfenati E, Gini G.
PMID: 20599297
Eur J Med Chem. 2010 Sep;45(9):4399-402. doi: 10.1016/j.ejmech.2010.06.019. Epub 2010 Jun 17.

Indices of the presence of atoms (IPA) encode the presence or absence of atoms, such as nitrogen, oxygen, sulphur, phosphorus, fluorine, chlorine, and bromine in a molecule. They are calculated with the simplified molecular input line entry system (SMILES)....

CORAL: building up the model for bioconcentration factor and defining it's applicability domain.

European journal of medicinal chemistry

Toropov AA, Toropova AP, Lombardo A, Roncaglioni A, Benfenati E, Gini G.
PMID: 21295893
Eur J Med Chem. 2011 Apr;46(4):1400-3. doi: 10.1016/j.ejmech.2011.01.018. Epub 2011 Jan 21.

CORAL (CORrelation And Logic) software can be used to build up the quantitative structure--property/activity relationships (QSPR/QSAR) with optimal descriptors calculated with the simplified molecular input line entry system (SMILES). We used CORAL to evaluate the applicability domain of the...

Synthesis, anti-GABA activity and preferred conformation of bicuculline and norbicuculline enantiomers.

European journal of medicinal chemistry

Kardos J, Blandl T, Luyen N, Dörnyei G, Gács-Baitz E, Simonyi M, Cash D, Blaskó G, Szántay C.
PMID: 22026931
Eur J Med Chem. 1996;31(10):761-5. doi: 10.1016/0223-5234(96)83969-9.

Synthesis of erythro-(±)-[1SR,9RS]-norbicuculline and threo-(±)-[1SR,9SR]-noradlumidine from piperonal was performed using Bischler-Napieralski cyclization as a key step. Resolution gave rise to (+)-[1S,9R]-norbicuculline ([1S,9R] norBIC) and (-)-[1R,9S]-norbicuculline ([1R,9S] norBIC) in >99.5% enantiomeric purity. Bicuculline enantiomers were readily obtained by methylation of...

RETRACTED: In vitro and in vivo biological potential and structural aspects of new diorganotin(IV) esters of N-maleoyl-beta-alanine.

European journal of medicinal chemistry

Khan MI, Baloch MK, Ashfaq M, Peters GJ.
PMID: 17049411
Eur J Med Chem. 2006 Oct 16; doi: 10.1016/j.ejmech.2006.07.008. Epub 2006 Oct 16.

This article has been retracted consistent with Elsevier Policy on Article Withdrawal. Please see The Publisher apologizes for any inconvenience this may cause.

Design, Synthesis, and Antifungal Activity of New α-Aminophosphonates.

International journal of medicinal chemistry

Rezaei Z, Khabnadideh S, Zomorodian K, Pakshir K, Nadali S, Mohtashami N, Faghih Mirzaei E.
PMID: 25954522
Int J Med Chem. 2011;2011:678101. doi: 10.1155/2011/678101. Epub 2011 Sep 26.

α-Aminophosphonates are bioisosteres of amino acids and have several pharmacological activities. These compounds have been synthesized by various routes from reaction between amine, aldehyde, and phosphite compounds. In order to synthesize α-aminophosphonates, catalytic effect of CuCl2 was compared with...

Showing 1 to 12 of 2012 entries