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Showing 1 to 12 of 2012 entries
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LARGE SCALE PURIFICATION OF BUTYRYLCHOLINESTERASE FROM HUMAN PLASMA SUITABLE FOR INJECTION INTO MONKEYS; A POTENTIAL NEW THERAPEUTIC FOR PROTECTION AGAINST COCAINE AND NERVE AGENT TOXICITY.

The journal of medical, chemical, biological, and radiological defense

Lockridge O, Schopfer LM, Winger G, Woods JH.
PMID: 16788731
J Med Chem Biol Radiol Def. 2005 Jul 01;3:nihms5095. doi: 10.1901/jaba.2005.3-nihms5095.

Pretreatment of animals with butyrylcholinesterase (EC 3.1.1.8 BChE) provides complete protection from the acute effects of organophosphorus nerve agents. Butyrylcholinesterase has also been shown to protect from cocaine toxicity. Large amounts of highly purified butyrylcholinesterase are needed to test...

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Lockridge O, Schopfer LM, Winger G, et al. LARGE SCALE PURIFICATION OF BUTYRYLCHOLINESTERASE FROM HUMAN PLASMA SUITABLE FOR INJECTION INTO MONKEYS; A POTENTIAL NEW THERAPEUTIC FOR PROTECTION AGAINST COCAINE AND NERVE AGENT TOXICITY. J Med Chem Biol Radiol Def. 2005;3:nihms5095doi: 10.1901/jaba.2005.3-nihms5095.
Lockridge, O., Schopfer, L. M., Winger, G., & Woods, J. H. (2005). LARGE SCALE PURIFICATION OF BUTYRYLCHOLINESTERASE FROM HUMAN PLASMA SUITABLE FOR INJECTION INTO MONKEYS; A POTENTIAL NEW THERAPEUTIC FOR PROTECTION AGAINST COCAINE AND NERVE AGENT TOXICITY. The journal of medical, chemical, biological, and radiological defense, 3nihms5095. https://doi.org/10.1901/jaba.2005.3-nihms5095
Lockridge, Oksana, et al. "LARGE SCALE PURIFICATION OF BUTYRYLCHOLINESTERASE FROM HUMAN PLASMA SUITABLE FOR INJECTION INTO MONKEYS; A POTENTIAL NEW THERAPEUTIC FOR PROTECTION AGAINST COCAINE AND NERVE AGENT TOXICITY." The journal of medical, chemical, biological, and radiological defense vol. 3 (2005): nihms5095. doi: https://doi.org/10.1901/jaba.2005.3-nihms5095
Lockridge O, Schopfer LM, Winger G, Woods JH. LARGE SCALE PURIFICATION OF BUTYRYLCHOLINESTERASE FROM HUMAN PLASMA SUITABLE FOR INJECTION INTO MONKEYS; A POTENTIAL NEW THERAPEUTIC FOR PROTECTION AGAINST COCAINE AND NERVE AGENT TOXICITY. J Med Chem Biol Radiol Def. 2005 Jul 01;3:nihms5095. doi: 10.1901/jaba.2005.3-nihms5095. PMID: 16788731; PMCID: PMC1480358.
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Design of Novel Amphipathic α-Helical Antimicrobial Peptides with No Toxicity as Therapeutics against the Antibiotic-Resistant Gram-Negative Bacterial Pathogen, .

Journal of medicinal chemistry and drug design

Mant CT, Jiang Z, Gera L, Davis T, Hodges RS.
PMID: 34377965
J Med Chem Drug Des. 2019;2(2). Epub 2019 May 30.

We designed

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Mant CT, Jiang Z, Gera L, et al. Design of Novel Amphipathic α-Helical Antimicrobial Peptides with No Toxicity as Therapeutics against the Antibiotic-Resistant Gram-Negative Bacterial Pathogen, . J Med Chem Drug Des. 2019;2(2)
Mant, C. T., Jiang, Z., Gera, L., Davis, T., & Hodges, R. S. (2019). Design of Novel Amphipathic α-Helical Antimicrobial Peptides with No Toxicity as Therapeutics against the Antibiotic-Resistant Gram-Negative Bacterial Pathogen, . Journal of medicinal chemistry and drug design, 2(2), .
Mant, Colin T, et al. "Design of Novel Amphipathic α-Helical Antimicrobial Peptides with No Toxicity as Therapeutics against the Antibiotic-Resistant Gram-Negative Bacterial Pathogen, ." Journal of medicinal chemistry and drug design vol. 2,2 (2019).
Mant CT, Jiang Z, Gera L, Davis T, Hodges RS. Design of Novel Amphipathic α-Helical Antimicrobial Peptides with No Toxicity as Therapeutics against the Antibiotic-Resistant Gram-Negative Bacterial Pathogen, . J Med Chem Drug Des. 2019;2(2). Epub 2019 May 30. PMID: 34377965; PMCID: PMC8351594.
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Research on heterocyclic compounds, XLI. 2-Phenylimidazo.

European journal of medicinal chemistry

Sacchi A, Laneri S, Arena F, Abignente E, Gallitelli M, D'amico M, Filippelli W, Rossi F.
PMID: 10889324
Eur J Med Chem. 1999 Nov 01;34(11):1003-1008. doi: 10.1016/s0223-5234(99)00112-9.

The synthesis of a group of 2-phenylimidazo[1,2-b]pyridazine-3-acetic esters and acids is described. The structures of the new compounds are supported by 1H-NMR spectra. These compounds were tested in vivo for their anti-inflammatory, analgesic and ulcerogenic activity. All new compounds...

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Sacchi A, Laneri S, Arena F, et al. Research on heterocyclic compounds, XLI. 2-Phenylimidazo. Eur J Med Chem. 1999;34(11):1003-1008doi: 10.1016/s0223-5234(99)00112-9.
Sacchi, A., Laneri, S., Arena, F., Abignente, E., Gallitelli, M., D'amico, M., Filippelli, W., & Rossi, F. (1999). Research on heterocyclic compounds, XLI. 2-Phenylimidazo. European journal of medicinal chemistry, 34(11), 1003-1008. https://doi.org/10.1016/s0223-5234(99)00112-9
Sacchi, et al. "Research on heterocyclic compounds, XLI. 2-Phenylimidazo." European journal of medicinal chemistry vol. 34,11 (1999): 1003-1008. doi: https://doi.org/10.1016/s0223-5234(99)00112-9
Sacchi A, Laneri S, Arena F, Abignente E, Gallitelli M, D'amico M, Filippelli W, Rossi F. Research on heterocyclic compounds, XLI. 2-Phenylimidazo. Eur J Med Chem. 1999 Nov 01;34(11):1003-1008. doi: 10.1016/s0223-5234(99)00112-9. PMID: 10889324.
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Synthesis, Characterization, and Antimicrobial Activity of a Novel Trisazo Dye from 3-Amino-4H-thieno[3,4-c][1]benzopyran-4-one.

International journal of medicinal chemistry

Tsemeugne J, Sopbué Fondjo E, Tamokou JD, Rohand T, Ngongang AD, Kuiate JR, Sondengam BL.
PMID: 29484208
Int J Med Chem. 2018 Feb 01;2018:9197821. doi: 10.1155/2018/9197821. eCollection 2018.

A new trisazo dye has been synthesized by coupling the diazonium ion of 3-amino-4H thieno[3,4-c][1]benzopyran-4-one with 2-

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Tsemeugne J, Sopbué Fondjo E, Tamokou JD, et al. Synthesis, Characterization, and Antimicrobial Activity of a Novel Trisazo Dye from 3-Amino-4H-thieno[3,4-c][1]benzopyran-4-one. Int J Med Chem. 2018;2018:9197821doi: 10.1155/2018/9197821.
Tsemeugne, J., Sopbué Fondjo, E., Tamokou, J. D., Rohand, T., Ngongang, A. D., Kuiate, J. R., & Sondengam, B. L. (2018). Synthesis, Characterization, and Antimicrobial Activity of a Novel Trisazo Dye from 3-Amino-4H-thieno[3,4-c][1]benzopyran-4-one. International journal of medicinal chemistry, 20189197821. https://doi.org/10.1155/2018/9197821
Tsemeugne, Joseph, et al. "Synthesis, Characterization, and Antimicrobial Activity of a Novel Trisazo Dye from 3-Amino-4H-thieno[3,4-c][1]benzopyran-4-one." International journal of medicinal chemistry vol. 2018 (2018): 9197821. doi: https://doi.org/10.1155/2018/9197821
Tsemeugne J, Sopbué Fondjo E, Tamokou JD, Rohand T, Ngongang AD, Kuiate JR, Sondengam BL. Synthesis, Characterization, and Antimicrobial Activity of a Novel Trisazo Dye from 3-Amino-4H-thieno[3,4-c][1]benzopyran-4-one. Int J Med Chem. 2018 Feb 01;2018:9197821. doi: 10.1155/2018/9197821. eCollection 2018. PMID: 29484208; PMCID: PMC5816859.
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Inhibition of RNA Helicases of ssRNA(+) Virus Belonging to Flaviviridae, Coronaviridae and Picornaviridae Families.

International journal of medicinal chemistry

Briguglio I, Piras S, Corona P, Carta A.
PMID: 27516903
Int J Med Chem. 2011;2011:213135. doi: 10.1155/2011/213135. Epub 2010 Nov 14.

Many viral pathogens encode the motor proteins named RNA helicases which display various functions in genome replication. General strategies to design specific and selective drugs targeting helicase for the treatment of viral infections could act via one or more...

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Briguglio I, Piras S, Corona P, et al. Inhibition of RNA Helicases of ssRNA(+) Virus Belonging to Flaviviridae, Coronaviridae and Picornaviridae Families. Int J Med Chem. 2010;2011:213135doi: 10.1155/2011/213135.
Briguglio, I., Piras, S., Corona, P., & Carta, A. (2011). Inhibition of RNA Helicases of ssRNA(+) Virus Belonging to Flaviviridae, Coronaviridae and Picornaviridae Families. International journal of medicinal chemistry, 2011213135. https://doi.org/10.1155/2011/213135
Briguglio, Irene, et al. "Inhibition of RNA Helicases of ssRNA(+) Virus Belonging to Flaviviridae, Coronaviridae and Picornaviridae Families." International journal of medicinal chemistry vol. 2011 (2011): 213135. doi: https://doi.org/10.1155/2011/213135
Briguglio I, Piras S, Corona P, Carta A. Inhibition of RNA Helicases of ssRNA(+) Virus Belonging to Flaviviridae, Coronaviridae and Picornaviridae Families. Int J Med Chem. 2011;2011:213135. doi: 10.1155/2011/213135. Epub 2010 Nov 14. PMID: 27516903; PMCID: PMC4970650.
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Studies on 16α-Hydroxylation of Steroid Molecules and Regioselective Binding Mode in Homology-Modeled Cytochrome P450-2C11.

International journal of medicinal chemistry

Ali HI, Yamada M, Fujita Y, Maeda M, Akaho E.
PMID: 27516905
Int J Med Chem. 2011;2011:918168. doi: 10.1155/2011/918168. Epub 2010 Jul 27.

We investigated the 16α-hydroxylation of steroid molecules and regioselective binding mode in homology-modeled cytochrome P450-2C11 to correlate the biological study with the computational molecular modeling. It revealed that there was a positive relationship between the observed inhibitory potencies and...

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Ali HI, Yamada M, Fujita Y, et al. Studies on 16α-Hydroxylation of Steroid Molecules and Regioselective Binding Mode in Homology-Modeled Cytochrome P450-2C11. Int J Med Chem. 2010;2011:918168doi: 10.1155/2011/918168.
Ali, H. I., Yamada, M., Fujita, Y., Maeda, M., & Akaho, E. (2011). Studies on 16α-Hydroxylation of Steroid Molecules and Regioselective Binding Mode in Homology-Modeled Cytochrome P450-2C11. International journal of medicinal chemistry, 2011918168. https://doi.org/10.1155/2011/918168
Ali, Hamed I, et al. "Studies on 16α-Hydroxylation of Steroid Molecules and Regioselective Binding Mode in Homology-Modeled Cytochrome P450-2C11." International journal of medicinal chemistry vol. 2011 (2011): 918168. doi: https://doi.org/10.1155/2011/918168
Ali HI, Yamada M, Fujita Y, Maeda M, Akaho E. Studies on 16α-Hydroxylation of Steroid Molecules and Regioselective Binding Mode in Homology-Modeled Cytochrome P450-2C11. Int J Med Chem. 2011;2011:918168. doi: 10.1155/2011/918168. Epub 2010 Jul 27. PMID: 27516905; PMCID: PMC4970648.
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Targeting Peroxisome Proliferator-Activated Receptors Using Thiazolidinediones: Strategy for Design of Novel Antidiabetic Drugs.

International journal of medicinal chemistry

Thangavel N, Al Bratty M, Akhtar Javed S, Ahsan W, Alhazmi HA.
PMID: 28656106
Int J Med Chem. 2017;2017:1069718. doi: 10.1155/2017/1069718. Epub 2017 Jun 05.

Thiazolidinediones are a class of well-established antidiabetic drugs, also named as glitazones. Thiazolidinedione structure has been an important structural domain of research, involving design and development of new drugs for the treatment of type 2 diabetes. Extensive research on...

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Thangavel N, Al Bratty M, Akhtar Javed S, et al. Targeting Peroxisome Proliferator-Activated Receptors Using Thiazolidinediones: Strategy for Design of Novel Antidiabetic Drugs. Int J Med Chem. 2017;2017:1069718doi: 10.1155/2017/1069718.
Thangavel, N., Al Bratty, M., Akhtar Javed, S., Ahsan, W., & Alhazmi, H. A. (2017). Targeting Peroxisome Proliferator-Activated Receptors Using Thiazolidinediones: Strategy for Design of Novel Antidiabetic Drugs. International journal of medicinal chemistry, 20171069718. https://doi.org/10.1155/2017/1069718
Thangavel, Neelaveni, et al. "Targeting Peroxisome Proliferator-Activated Receptors Using Thiazolidinediones: Strategy for Design of Novel Antidiabetic Drugs." International journal of medicinal chemistry vol. 2017 (2017): 1069718. doi: https://doi.org/10.1155/2017/1069718
Thangavel N, Al Bratty M, Akhtar Javed S, Ahsan W, Alhazmi HA. Targeting Peroxisome Proliferator-Activated Receptors Using Thiazolidinediones: Strategy for Design of Novel Antidiabetic Drugs. Int J Med Chem. 2017;2017:1069718. doi: 10.1155/2017/1069718. Epub 2017 Jun 05. PMID: 28656106; PMCID: PMC5474549.
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A new bioconcentration factor model based on SMILES and indices of presence of atoms.

European journal of medicinal chemistry

Toropova AP, Toropov AA, Lombardo A, Roncaglioni A, Benfenati E, Gini G.
PMID: 20599297
Eur J Med Chem. 2010 Sep;45(9):4399-402. doi: 10.1016/j.ejmech.2010.06.019. Epub 2010 Jun 17.

Indices of the presence of atoms (IPA) encode the presence or absence of atoms, such as nitrogen, oxygen, sulphur, phosphorus, fluorine, chlorine, and bromine in a molecule. They are calculated with the simplified molecular input line entry system (SMILES)....

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Toropova AP, Toropov AA, Lombardo A, et al. A new bioconcentration factor model based on SMILES and indices of presence of atoms. Eur J Med Chem. 2010;45(9):4399-402doi: 10.1016/j.ejmech.2010.06.019.
Toropova, A. P., Toropov, A. A., Lombardo, A., Roncaglioni, A., Benfenati, E., & Gini, G. (2010). A new bioconcentration factor model based on SMILES and indices of presence of atoms. European journal of medicinal chemistry, 45(9), 4399-402. https://doi.org/10.1016/j.ejmech.2010.06.019
Toropova, A P, et al. "A new bioconcentration factor model based on SMILES and indices of presence of atoms." European journal of medicinal chemistry vol. 45,9 (2010): 4399-402. doi: https://doi.org/10.1016/j.ejmech.2010.06.019
Toropova AP, Toropov AA, Lombardo A, Roncaglioni A, Benfenati E, Gini G. A new bioconcentration factor model based on SMILES and indices of presence of atoms. Eur J Med Chem. 2010 Sep;45(9):4399-402. doi: 10.1016/j.ejmech.2010.06.019. Epub 2010 Jun 17. PMID: 20599297.
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CORAL: building up the model for bioconcentration factor and defining it's applicability domain.

European journal of medicinal chemistry

Toropov AA, Toropova AP, Lombardo A, Roncaglioni A, Benfenati E, Gini G.
PMID: 21295893
Eur J Med Chem. 2011 Apr;46(4):1400-3. doi: 10.1016/j.ejmech.2011.01.018. Epub 2011 Jan 21.

CORAL (CORrelation And Logic) software can be used to build up the quantitative structure--property/activity relationships (QSPR/QSAR) with optimal descriptors calculated with the simplified molecular input line entry system (SMILES). We used CORAL to evaluate the applicability domain of the...

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Toropov AA, Toropova AP, Lombardo A, et al. CORAL: building up the model for bioconcentration factor and defining it's applicability domain. Eur J Med Chem. 2011;46(4):1400-3doi: 10.1016/j.ejmech.2011.01.018.
Toropov, A. A., Toropova, A. P., Lombardo, A., Roncaglioni, A., Benfenati, E., & Gini, G. (2011). CORAL: building up the model for bioconcentration factor and defining it's applicability domain. European journal of medicinal chemistry, 46(4), 1400-3. https://doi.org/10.1016/j.ejmech.2011.01.018
Toropov, A A, et al. "CORAL: building up the model for bioconcentration factor and defining it's applicability domain." European journal of medicinal chemistry vol. 46,4 (2011): 1400-3. doi: https://doi.org/10.1016/j.ejmech.2011.01.018
Toropov AA, Toropova AP, Lombardo A, Roncaglioni A, Benfenati E, Gini G. CORAL: building up the model for bioconcentration factor and defining it's applicability domain. Eur J Med Chem. 2011 Apr;46(4):1400-3. doi: 10.1016/j.ejmech.2011.01.018. Epub 2011 Jan 21. PMID: 21295893.
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Synthesis, anti-GABA activity and preferred conformation of bicuculline and norbicuculline enantiomers.

European journal of medicinal chemistry

Kardos J, Blandl T, Luyen N, Dörnyei G, Gács-Baitz E, Simonyi M, Cash D, Blaskó G, Szántay C.
PMID: 22026931
Eur J Med Chem. 1996;31(10):761-5. doi: 10.1016/0223-5234(96)83969-9.

Synthesis of erythro-(±)-[1SR,9RS]-norbicuculline and threo-(±)-[1SR,9SR]-noradlumidine from piperonal was performed using Bischler-Napieralski cyclization as a key step. Resolution gave rise to (+)-[1S,9R]-norbicuculline ([1S,9R] norBIC) and (-)-[1R,9S]-norbicuculline ([1R,9S] norBIC) in >99.5% enantiomeric purity. Bicuculline enantiomers were readily obtained by methylation of...

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Kardos J, Blandl T, Luyen N, et al. Synthesis, anti-GABA activity and preferred conformation of bicuculline and norbicuculline enantiomers. Eur J Med Chem. 1996;31(10):761-5doi: 10.1016/0223-5234(96)83969-9.
Kardos, J., Blandl, T., Luyen, N., Dörnyei, G., Gács-Baitz, E., Simonyi, M., Cash, D., Blaskó, G., & Szántay, C. (1996). Synthesis, anti-GABA activity and preferred conformation of bicuculline and norbicuculline enantiomers. European journal of medicinal chemistry, 31(10), 761-5. https://doi.org/10.1016/0223-5234(96)83969-9
Kardos, J, et al. "Synthesis, anti-GABA activity and preferred conformation of bicuculline and norbicuculline enantiomers." European journal of medicinal chemistry vol. 31,10 (1996): 761-5. doi: https://doi.org/10.1016/0223-5234(96)83969-9
Kardos J, Blandl T, Luyen N, Dörnyei G, Gács-Baitz E, Simonyi M, Cash D, Blaskó G, Szántay C. Synthesis, anti-GABA activity and preferred conformation of bicuculline and norbicuculline enantiomers. Eur J Med Chem. 1996;31(10):761-5. doi: 10.1016/0223-5234(96)83969-9. PMID: 22026931.
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RETRACTED: In vitro and in vivo biological potential and structural aspects of new diorganotin(IV) esters of N-maleoyl-beta-alanine.

European journal of medicinal chemistry

Khan MI, Baloch MK, Ashfaq M, Peters GJ.
PMID: 17049411
Eur J Med Chem. 2006 Oct 16; doi: 10.1016/j.ejmech.2006.07.008. Epub 2006 Oct 16.

This article has been retracted consistent with Elsevier Policy on Article Withdrawal. Please see The Publisher apologizes for any inconvenience this may cause.

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Khan MI, Baloch MK, Ashfaq M, et al. RETRACTED: In vitro and in vivo biological potential and structural aspects of new diorganotin(IV) esters of N-maleoyl-beta-alanine. Eur J Med Chem. 2006;doi: 10.1016/j.ejmech.2006.07.008.
Khan, M. I., Baloch, M. K., Ashfaq, M., & Peters, G. J. (2006). RETRACTED: In vitro and in vivo biological potential and structural aspects of new diorganotin(IV) esters of N-maleoyl-beta-alanine. European journal of medicinal chemistry, . https://doi.org/10.1016/j.ejmech.2006.07.008
Khan, M I, et al. "RETRACTED: In vitro and in vivo biological potential and structural aspects of new diorganotin(IV) esters of N-maleoyl-beta-alanine." European journal of medicinal chemistry vol. (2006). doi: https://doi.org/10.1016/j.ejmech.2006.07.008
Khan MI, Baloch MK, Ashfaq M, Peters GJ. RETRACTED: In vitro and in vivo biological potential and structural aspects of new diorganotin(IV) esters of N-maleoyl-beta-alanine. Eur J Med Chem. 2006 Oct 16; doi: 10.1016/j.ejmech.2006.07.008. Epub 2006 Oct 16. PMID: 17049411.
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Design, Synthesis, and Antifungal Activity of New α-Aminophosphonates.

International journal of medicinal chemistry

Rezaei Z, Khabnadideh S, Zomorodian K, Pakshir K, Nadali S, Mohtashami N, Faghih Mirzaei E.
PMID: 25954522
Int J Med Chem. 2011;2011:678101. doi: 10.1155/2011/678101. Epub 2011 Sep 26.

α-Aminophosphonates are bioisosteres of amino acids and have several pharmacological activities. These compounds have been synthesized by various routes from reaction between amine, aldehyde, and phosphite compounds. In order to synthesize α-aminophosphonates, catalytic effect of CuCl2 was compared with...

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Rezaei Z, Khabnadideh S, Zomorodian K, et al. Design, Synthesis, and Antifungal Activity of New α-Aminophosphonates. Int J Med Chem. 2011;2011:678101doi: 10.1155/2011/678101.
Rezaei, Z., Khabnadideh, S., Zomorodian, K., Pakshir, K., Nadali, S., Mohtashami, N., & Faghih Mirzaei, E. (2011). Design, Synthesis, and Antifungal Activity of New α-Aminophosphonates. International journal of medicinal chemistry, 2011678101. https://doi.org/10.1155/2011/678101
Rezaei, Zahra, et al. "Design, Synthesis, and Antifungal Activity of New α-Aminophosphonates." International journal of medicinal chemistry vol. 2011 (2011): 678101. doi: https://doi.org/10.1155/2011/678101
Rezaei Z, Khabnadideh S, Zomorodian K, Pakshir K, Nadali S, Mohtashami N, Faghih Mirzaei E. Design, Synthesis, and Antifungal Activity of New α-Aminophosphonates. Int J Med Chem. 2011;2011:678101. doi: 10.1155/2011/678101. Epub 2011 Sep 26. PMID: 25954522; PMCID: PMC4412091.
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Showing 1 to 12 of 2012 entries