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Showing 1 to 12 of 563 entries
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A novel del(8)(q23.2q24.11) contributing to disease progression in a case of JAK2/TET2 double mutated chronic myelomonocytic leukemia.

Leukemia research reports

Toft-Petersen M, Kjeldsen E, Nederby L, Grønbæk K, Hokland P, Roug AS.
PMID: 25473623
Leuk Res Rep. 2014 Nov 13;3(2):94-7. doi: 10.1016/j.lrr.2014.09.002. eCollection 2014.

We have identified a novel 7.7 Mb del(8)(q23.2q24.11) in a patient progressing to acute myeloid leukemia (AML) following a 12-year stable phase of chronic myelomonocytic leukemia (CMML). A surprisingly high JAK2+ allelic burden of 92% at the time of...

A molecular risk score integrating BAALC, ERG and WT1 expression levels for risk stratification in acute promyelocytic leukemia.

Leukemia research

Hecht A, Nowak D, Nowak V, Hanfstein B, Büchner T, Spiekermann K, Weiß C, Hofmann WK, Lengfelder E, Nolte F.
PMID: 26344466
Leuk Res. 2015 Aug 20; doi: 10.1016/j.leukres.2015.08.010. Epub 2015 Aug 20.

To date risk stratification in acute promyelocytic leukemia (APL) is based on highly dynamic leukocyte and platelet counts only. To identify a more robust risk stratification model, a molecular risk score was developed based on expression levels of the...

Characteristics of Adult T-Cell Leukemia/Lymphoma Patients with Long Survival: Prognostic Significance of Skin Lesions and Possible Beneficial Role of Valproic Acid.

Leukemia research and treatment

Yves P, Stephane M, Rishika B, Christine D, Gérard P.
PMID: 26199759
Leuk Res Treatment. 2015;2015:476805. doi: 10.1155/2015/476805. Epub 2015 Jun 14.

We describe the clinical and biological features of ten patients with a survival superior to ten years (long survival), out of 175 patients diagnosed with Adult T-cell Leukemia/Lymphoma (ATL) in Martinique (1983-2013). There were 5 lymphoma and 5 chronic...

Four hepatosplenic T-cell lymphoma cases of Japanese patients.

Leukemia research reports

Kawai H, Matsushita H, Ohmachi K, Kojima M, Machida S, Ogawa Y, Kawada H, Nakamura N, Ando K.
PMID: 26870659
Leuk Res Rep. 2015 Dec 15;5:3-6. doi: 10.1016/j.lrr.2015.12.001. eCollection 2016.

Hepatosplenic T-cell lymphoma (HSTCL), a rare type of γδ T-cell lymphoma, is characterized by hepatosplenomegaly and cytopenias. It is associated with immunodeficiency and its age of onset is reportedly between the 20s and 30s. We herein report 4 Japanese...

[In Process Citation].

Leukemia research

Gisslinger H, Penka M.
PMID: 27130523
Leuk Res. 2016 May;44:v. doi: 10.1016/S0145-2126(16)30070-4. Epub 2016 Apr 26.

No abstract available.

Kinetics of del(7q) driven leukemogenesis in a patient with JAK2 V617F and TET2 mutated chronic myeloproliferative neoplasm.

Leukemia research reports

Herborg LL, Nederby L, Kjeldsen E, Grønbæk K, Hokland P, Hansen M, Celik Hansen M, Roug AS.
PMID: 24371780
Leuk Res Rep. 2013 Jul 04;2(2):51-3. doi: 10.1016/j.lrr.2013.06.001. eCollection 2013.

Chronic myeloid neoplasms have susceptibility to transform into acute myeloid leukemia due to attainment of additional molecular lesions. We here describe the kinetics of a del(7q) driven leukemogenesis in a patient with multiple TET2 mutations and JAK2 V617F mutated...

Short communications and case reports-Who cares?.

Leukemia research reports

Mundle S, Wetzler M.
PMID: 24371762
Leuk Res Rep. 2012 Nov 21;1(1):A1. doi: 10.1016/j.lrr.2012.11.001. eCollection 2012.

No abstract available.

The use of low-dose protracted oral clofarabine in a patient with myelodysplastic syndrome after failing 5-azacitidine.

Leukemia research reports

Al Ustwani O, Greene JD, Wetzler M.
PMID: 24371774
Leuk Res Rep. 2013 Apr 30;2(1):34-5. doi: 10.1016/j.lrr.2013.03.002. eCollection 2013.

Patients with myelodysplastic syndrome who fail hypomethylating agents have a very short median survival and about 25% risk of disease transformation to acute myeloid leukemia. We report our experience with low-dose protracted oral clofarabine in one patient who achieved...

Translocation (8;21) acute myeloid leukemia presenting as severe aplastic anemia.

Leukemia research reports

Purev E, Dumitriu B, Hourigan CS, Young NS, Townsley DM.
PMID: 25003026
Leuk Res Rep. 2014 Jun 11;3(2):46-8. doi: 10.1016/j.lrr.2014.04.002. eCollection 2014.

We report a case of t(8;21) acute myeloid leukemia presenting as severe aplastic anemia. While initial bone marrow biopsy lacked any cytogenetic abnormalities in 20 analyzed metaphases, repeat bone marrow biopsy eight days later demonstrated this translocation. Initial cytogenetic...

Extracellular crystals in plasma cell myeloma.

Leukemia research reports

Brown JT, Burack WR, Becker MW, Vlad-Vonica R, Nadasdy T, Bennett JM, Mendler JH.
PMID: 25003027
Leuk Res Rep. 2014 Jun 18;3(2):49-50. doi: 10.1016/j.lrr.2014.04.004. eCollection 2014.

No abstract available.

Linking the SUMO protease SENP5 to neutrophil differentiation of AML cells.

Leukemia research reports

Federzoni EA, Gloor S, Jin J, Shan-Krauer D, Fey MF, Torbett BE, Tschan MP.
PMID: 25984443
Leuk Res Rep. 2015 Apr 23;4(1):32-5. doi: 10.1016/j.lrr.2015.04.002. eCollection 2015.

In an mRNA profiling screen performed to unveil novel mechanisms of leukemogenesis, we found that the sentrin-specific protease 5 (SENP5) was significantly repressed in clinical acute myeloid leukemia when compared to healthy neutrophil samples. SENP5 is an enzyme that...

Prognostic impact of combined NPM1+/FLT3- genotype in patients with acute myeloid leukemia with intermediate risk cytogenetics stratified by age and treatment modalities.

Leukemia research

Hefazi M, Siddiqui M, Patnaik M, Wolanskyj A, Alkhateeb H, Zblewski D, Elliott M, Hogan W, Litzow M, Al-Kali A.
PMID: 26410460
Leuk Res. 2015 Sep 03; doi: 10.1016/j.leukres.2015.09.001. Epub 2015 Sep 03.

The prognostic impact of combined NPM1+/FLT3- genotype is not well defined in elderly patients with acute myeloid leukemia (AML), and in the setting of different treatments, such as cytotoxic chemotherapy (Chemo), hematopoietic cell transplantation (HCT), or hypomethylating agents (HMA)....

Showing 1 to 12 of 563 entries