Advanced Search
Display options
Filter resources
Text Availability
Article type
Publication date
Species
Language
Sex
Age
Showing 1 to 12 of 169 entries
Sorted by: Best Match Show Resources per page
Quantitative Systems Biology to decipher design principles of a dynamic cell cycle network: the "Maximum Allowable mammalian Trade-Off-Weight" (MAmTOW).

NPJ systems biology and applications

Barberis M, Verbruggen P.
PMID: 28944079
NPJ Syst Biol Appl. 2017 Sep 19;3:26. doi: 10.1038/s41540-017-0028-x. eCollection 2017.

Network complexity is required to lend cellular processes flexibility to respond timely to a variety of dynamic signals, while simultaneously warranting robustness to protect cellular integrity against perturbations. The cell cycle serves as a paradigm for such processes; it...

Computer modeling defines the system driving a constant current crucial for homeostasis in the mammalian cochlea by integrating unique ion transports.

NPJ systems biology and applications

Nin F, Yoshida T, Murakami S, Ogata G, Uetsuka S, Choi S, Doi K, Sawamura S, Inohara H, Komune S, Kurachi Y, Hibino H.
PMID: 28861279
NPJ Syst Biol Appl. 2017 Aug 25;3:24. doi: 10.1038/s41540-017-0025-0. eCollection 2017.

The cochlear lateral wall-an epithelial-like tissue comprising inner and outer layers-maintains +80 mV in endolymph. This endocochlear potential supports hearing and represents the sum of all membrane potentials across apical and basolateral surfaces of both layers. The apical surfaces...

SalmoNet, an integrated network of ten .

NPJ systems biology and applications

Métris A, Sudhakar P, Fazekas D, Demeter A, Ari E, Olbei M, Branchu P, Kingsley RA, Baranyi J, Korcsmáros T.
PMID: 29057095
NPJ Syst Biol Appl. 2017 Oct 18;3:31. doi: 10.1038/s41540-017-0034-z. eCollection 2017.

No abstract available.

Detecting phenotype-driven transitions in regulatory network structure.

NPJ systems biology and applications

Padi M, Quackenbush J.
PMID: 29707235
NPJ Syst Biol Appl. 2018 Apr 19;4:16. doi: 10.1038/s41540-018-0052-5. eCollection 2018.

Complex traits and diseases like human height or cancer are often not caused by a single mutation or genetic variant, but instead arise from functional changes in the underlying molecular network. Biological networks are known to be highly modular...

Deconstructing the traditional Japanese medicine "Kampo": compounds, metabolites and pharmacological profile of maoto, a remedy for flu-like symptoms.

NPJ systems biology and applications

Nishi A, Ohbuchi K, Kushida H, Matsumoto T, Lee K, Kuroki H, Nabeshima S, Shimobori C, Komokata N, Kanno H, Tsuchiya N, Zushi M, Hattori T, Yamamoto M, Kase Y, Matsuoka Y, Kitano H.
PMID: 29075514
NPJ Syst Biol Appl. 2017 Oct 24;3:32. doi: 10.1038/s41540-017-0032-1. eCollection 2017.

Pharmacological activities of the traditional Japanese herbal medicine (Kampo) are putatively mediated by complex interactions between multiple herbal compounds and host factors, which are difficult to characterize via the reductive approach of purifying major bioactive compounds and elucidating their...

Large-scale computational drug repositioning to find treatments for rare diseases.

NPJ systems biology and applications

Govindaraj RG, Naderi M, Singha M, Lemoine J, Brylinski M.
PMID: 29560273
NPJ Syst Biol Appl. 2018 Mar 13;4:13. doi: 10.1038/s41540-018-0050-7. eCollection 2018.

Rare, or orphan, diseases are conditions afflicting a small subset of people in a population. Although these disorders collectively pose significant health care problems, drug companies require government incentives to develop drugs for rare diseases due to extremely limited...

Elucidation of the molecular mechanisms underlying adverse reactions associated with a kinase inhibitor using systems toxicology.

NPJ systems biology and applications

Amemiya T, Honma M, Kariya Y, Ghosh S, Kitano H, Kurachi Y, Fujita KI, Sasaki Y, Homma Y, Abernethy DR, Kume H, Suzuki H.
PMID: 28725458
NPJ Syst Biol Appl. 2015 Sep 28;1:15005. doi: 10.1038/npjsba.2015.5. eCollection 2015.

CONCLUSIONS: A systems toxicological approach successfully predicted the molecular mechanisms underlying clinically adverse reactions associated with sunitinib and was used to plan a rational method for the management of these adverse reactions.

From START to FINISH: computational analysis of cell cycle control in budding yeast.

NPJ systems biology and applications

Kraikivski P, Chen KC, Laomettachit T, Murali TM, Tyson JJ.
PMID: 28725464
NPJ Syst Biol Appl. 2015 Dec 10;1:15016. doi: 10.1038/npjsba.2015.16. eCollection 2015.

In the cell division cycle of budding yeast, START refers to a set of tightly linked events that prepare a cell for budding and DNA replication, and FINISH denotes the interrelated events by which the cell exits from mitosis...

Systems biology driving drug development: from design to the clinical testing of the anti-ErbB3 antibody seribantumab (MM-121).

NPJ systems biology and applications

Schoeberl B, Kudla A, Masson K, Kalra A, Curley M, Finn G, Pace E, Harms B, Kim J, Kearns J, Fulgham A, Burenkova O, Grantcharova V, Yarar D, Paragas V, Fitzgerald J, Wainszelbaum M, West K, Mathews S, Nering R, Adiwijaya B, Garcia G, Kubasek B, Moyo V, Czibere A, Nielsen UB, MacBeath G.
PMID: 28725482
NPJ Syst Biol Appl. 2017 Jan 05;3:16034. doi: 10.1038/npjsba.2016.34. eCollection 2017.

The ErbB family of receptor tyrosine kinases comprises four members: epidermal growth factor receptor (EGFR/ErbB1), human EGFR 2 (HER2/ErbB2), ErbB3/HER3, and ErbB4/HER4. The first two members of this family, EGFR and HER2, have been implicated in tumorigenesis and cancer...

Integrative analysis of pathway deregulation in obesity.

NPJ systems biology and applications

Font-Clos F, Zapperi S, La Porta CAM.
PMID: 28685099
NPJ Syst Biol Appl. 2017 Jun 30;3:18. doi: 10.1038/s41540-017-0018-z. eCollection 2017.

Obesity is a pandemic disease, linked to the onset of type 2 diabetes and cancer. Transcriptomic data provides a picture of the alterations in regulatory and metabolic activities associated with obesity, but its interpretation is typically blurred by noise....

Next-generation mammalian genetics toward organism-level systems biology.

NPJ systems biology and applications

Susaki EA, Ukai H, Ueda HR.
PMID: 28649442
NPJ Syst Biol Appl. 2017 Jun 05;3:15. doi: 10.1038/s41540-017-0015-2. eCollection 2017.

Organism-level systems biology in mammals aims to identify, analyze, control, and design molecular and cellular networks executing various biological functions in mammals. In particular, system-level identification and analysis of molecular and cellular networks can be accelerated by next-generation mammalian...

Elucidating the genotype-phenotype map by automatic enumeration and analysis of the phenotypic repertoire.

NPJ systems biology and applications

Lomnitz JG, Savageau MA.
PMID: 26998346
NPJ Syst Biol Appl. 2015;1. doi: 10.1038/npjsba.2015.3. Epub 2015 Sep 28.

BACKGROUND: The gap between genotype and phenotype is filled by complex biochemical systems most of which are poorly understood. Because these systems are complex, it is widely appreciated that quantitative understanding can only be achieved with the aid of...

Showing 1 to 12 of 169 entries