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The Bio-Persistence of Reversible Inflammatory, Histological Changes and Metabolic Profile Alterations in Rat Livers after Silver/Gold Nanorod Administration.

Nanomaterials (Basel, Switzerland)

Liu Y, Wen H, Wu X, Wu M, Liu L, Wang J, Huo G, Lyu J, Xie L, Dan M.
PMID: 34685095
Nanomaterials (Basel). 2021 Oct 09;11(10). doi: 10.3390/nano11102656.

As a widely applied nanomaterial, silver nanomaterials (AgNMs) have increased public concern about their potential adverse biological effects. However, there are few related researches on the long-term toxicity, especially on the reversibility of AgNMs in vivo. In the current...

Pharmacokinetic effects of proton pump inhibitors on the novel PARP inhibitor fluzoparib: a single-arm, fixed-sequence trial in male healthy volunteers.

Investigational new drugs

Li L, Xiang YX, Yang GP, Zhang XF, Yang XY, Yang S, Huang J.
PMID: 33420642
Invest New Drugs. 2021 Jun;39(3):796-802. doi: 10.1007/s10637-020-01034-w. Epub 2021 Jan 09.

Purpose To assess the pharmacokinetic (PK) effect of proton pump inhibitors on the novel poly(adenosine diphosphate-ribose) polymerase (PARP) inhibitor fluzoparib, and observe the safety of its co-administration with omeprazole. Patients and methods Sixteen male healthy volunteers (HVs) were enrolled...

Roles of ROS and cell cycle arrest in the genotoxicity induced by gold nanorod core/silver shell nanostructure.

Nanoscale research letters

Wang D, Dan M, Ji Y, Wu X, Wang X, Wen H.
PMID: 33284367
Nanoscale Res Lett. 2020 Dec 07;15(1):224. doi: 10.1186/s11671-020-03455-1.

To understand the genotoxicity induced in the liver by silver nanoparticles (AgNPs) and silver ions, an engineered gold nanorod core/silver shell nanostructure (Au@Ag NR) and humanized hepatocyte HepaRG cells were used in this study. The involvement of oxidative stress...

Are the optimum pharmaceutical preparations used for the second-line eradication therapy for helicobacter pylori infection in Japan? - a discussion from a simulation for the amount of antibiotics in stomach based on the data of dissolution studies -.

Journal of basic and clinical pharmacy

Kubodera M, Tokumura T, Machida Y.
PMID: 24825995
J Basic Clin Pharm. 2010 Sep;1(4):255-61. Epub 2010 Nov 15.

The purpose of this study was to evaluate whether the optimum preparations are used for the second-line eradication therapy for Helicobacter pylori (H. pylori) infection in Japan. In the therapy, commercial tablets, which have 250 mg of amoxicillin (AMX)...

Potential antioxidant properties and hepatoprotective effects of Juniperus phoenicea berries against CCl.

Asian Pacific journal of tropical medicine

Laouar A, Klibet F, Bourogaa E, Benamara A, Boumendjel A, Chefrour A, Messarah M.
PMID: 28442109
Asian Pac J Trop Med. 2017 Mar;10(3):263-269. doi: 10.1016/j.apjtm.2017.03.005. Epub 2017 Mar 07.

OBJECTIVE: To investigate the antioxidant and hepatoprotective properties of Juniperus phoenicea (J. phoenicea) berries against CClMETHODS: Hepatotoxicity was induced in albino Wistar rats by single dose of CClRESULTS: Obtained results revealed that administration of CClCONCLUSIONS: The results of the...

Analytical investigations of beta-lactam antibiotics in pharmaceutical preparations-II. Spectrophotometric determination of cephalexin, cephradine, ampicillin and amoxycillin using copper(II) acetate as a completing agent.

Journal of pharmaceutical and biomedical analysis

Issopoulos PB.
PMID: 16867424
J Pharm Biomed Anal. 1988;6(3):321-7. doi: 10.1016/0731-7085(88)80060-8.

No abstract available.

Selective determination of thiamine (vitamin B(1)) in pharmaceutical preparations by direct potentiometric argentometric titration with use of the silver-silver sulphide ion-selective electrode.


Hassan SS, Elnemma E.
PMID: 18964853
Talanta. 1989 Oct;36(10):1011-5. doi: 10.1016/0039-9140(89)80184-5.

A simple and selective argentometric titration method is described for determination of thiamine (vitamin B(1)), based on direct potentiometric titration in alkaline media (0.5M) in which a chemical transformation takes place, creating two acidic groups, the protons of which...

Detection and quantitation of trace phenolphthalein (in pharmaceutical preparations and in forensic exhibits) by liquid chromatography-tandem mass spectrometry, a sensitive and accurate method.

Journal of forensic sciences

Sharma K, Sharma SP, Lahiri SC.
PMID: 23106487
J Forensic Sci. 2013 Jan;58:S208-14. doi: 10.1111/1556-4029.12007. Epub 2012 Oct 26.

Phenolphthalein, an acid-base indicator and laxative, is important as a constituent of widely used weight-reducing multicomponent food formulations. Phenolphthalein is an useful reagent in forensic science for the identification of blood stains of suspected victims and for apprehending erring...

Efficiency enhancement of the spectrophotometric estimation of cobalt in waters and pharmaceutical preparations using dispersive liquid-liquid microextraction and microcells with long optical paths.

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy

Al-Saidi HM, Alharthi SS.
PMID: 33621935
Spectrochim Acta A Mol Biomol Spectrosc. 2021 May 15;253:119552. doi: 10.1016/j.saa.2021.119552. Epub 2021 Feb 05.

In this paper, dispersive liquid-liquid microextraction (DLLME), long optical path microcells, and a selective chromogenic reagent were employed to improve the analytical efficiency of cobalt determination by spectrophotometry. The methodology proposed in the present study is based upon the...

Interleukin-17-Producing CD4.

Frontiers in cardiovascular medicine

Wang Y, Li W, Zhao T, Zou Y, Deng T, Yang Z, Yuan Z, Ma L, Yu R, Wang T, Yu C.
PMID: 33981738
Front Cardiovasc Med. 2021 Apr 26;8:667768. doi: 10.3389/fcvm.2021.667768. eCollection 2021.

Atherosclerosis is a chronic inflammatory disease. Interleukin-17-producing CD4

Novel and validated titrimetric method for determination of selected angiotensin-II-receptor antagonists in pharmaceutical preparations and its comparison with UV spectrophotometric determination.

Journal of pharmaceutical analysis

Patil SH, Janjale MV.
PMID: 29403786
J Pharm Anal. 2012 Dec;2(6):470-477. doi: 10.1016/j.jpha.2012.03.009. Epub 2012 Apr 09.

A novel and simple titrimetric method for determination of commonly used angiotensin-II-receptor antagonists (ARA-IIs) is developed and validated. The direct acid base titration of four ARA-IIs, namely eprosartan mesylate, irbesartan, telmisartan and valsartan, was carried out in the mixture...

Enhanced nuclear gene delivery via integrating and streamlining intracellular pathway.

Journal of controlled release : official journal of the Controlled Release Society

Qi LY, Wang Y, Hu LF, Zhao PS, Yu HY, Xing L, Gao XD, Cao QR, Jiang HL.
PMID: 34864117
J Control Release. 2021 Dec 02; doi: 10.1016/j.jconrel.2021.11.046. Epub 2021 Dec 02.

The essential challenge of gene therapy is to develop safe and efficient vectors that escort genes to target sites. However, due to the cumbersome workflow of gene transfection into cells, successive gene loss occurs. This leads to considerable reductions...

Showing 1 to 12 of 1539 entries