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Showing 1 to 12 of 548 entries
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CYP2B6 Genotype Guided Dosing of Propofol Anesthesia in the Elderly based on Nonparametric Population Pharmacokinetic Modeling and Simulations.

International journal of clinical pharmacology & toxicology

Eugene AR.
PMID: 28154789
Int J Clin Pharmacol Toxicol. 2017;6(1):242-249. Epub 2017 Jan 03.

OBJECTIVE: The primary aim of this article is to test the hypothesis that nonparametric pharmacometric modeling will accurately identify CYP2B6 genotype subgroups based on data from a study that reported results based on parametric pharmacokinetics (PK).METHODS: Propofol concentration-time data...

Gender based Dosing of Metoprolol in the Elderly using Population Pharmacokinetic Modeling and Simulations.

International journal of clinical pharmacology & toxicology

Eugene AR.
PMID: 27468378
Int J Clin Pharmacol Toxicol. 2016 May;5(3):209-215. Epub 2016 May 19.

INTRODUCTION: This article seeks to clarify if gender-based differences occur in the pharmacokinetics of metoprolol in the elderly patients. There are a series of physiologic changes that occur in the elderly ranging from decreased hepatic blood flow to increased...

Identifying Treatment Response of Sertraline in a Teenager with Selective Mutism using Electrophysiological Neuroimaging.

International journal of clinical pharmacology & toxicology

Eugene AR, Masiak J.
PMID: 27468379
Int J Clin Pharmacol Toxicol. 2016 Jun;5(4):216-219. Epub 2016 Jun 15.

BACKGROUND: Selective Mutism is described as the inability to verbally express oneself in anxiety provoking social situations and may result in awkward social interactions in school-aged children. In this case-report we present the baseline electrophysiological neuroimaging results and after...

AT.

International journal of clinical pharmacology & toxicology

Ali Q, Hussain T.
PMID: 27588222
Int J Clin Pharmacol Toxicol. 2012 Oct;1(1):15-19. doi: 10.19070/2167-910X-120003. Epub 2012 Oct 16.

The renin-angiotensin system (RAS) is a hormonal cascade that acts together to regulate blood pressure. Angiotensin II (Ang II) is the major octapeptide of RAS and mediates its cellular and physiological actions by acting on AT

Simulation of clinical trials.

Annual review of pharmacology and toxicology

Holford NH, Kimko HC, Monteleone JP, Peck CC.
PMID: 10836134
Annu Rev Pharmacol Toxicol. 2000;40:209-34. doi: 10.1146/annurev.pharmtox.40.1.209.

Computer simulation of clinical trials has evolved over the past two decades from a simple instructive game to "full" simulation models yielding pharmacologically sound, realistic trial outcomes. The need to make drug development more efficient and informative and the...

Johan Gunnar AHLGREN.

Acta pharmacologica et toxicologica

MOLLER KO.
PMID: 13935886
Acta Pharmacol Toxicol (Copenh). 1962;19:392-4.

No abstract available.

Obviously nine believers: Actionable germline genetic variants for pre-emptive pharmacogenetic testing.

Basic & clinical pharmacology & toxicology

Damkier P.
PMID: 31597220
Basic Clin Pharmacol Toxicol. 2019 Oct 09; doi: 10.1111/bcpt.13335. Epub 2019 Oct 09.

No abstract available.

Extended recording of LMA in rats: Effects of IV catheters, "comfort jackets" and chamber lids on arterial blood gas parameters.

Journal of pharmacological and toxicological methods

Gauvin DV, Zimmermann ZJ, Dalton JA, Baird TJ.
PMID: 31158458
J Pharmacol Toxicol Methods. 2019 Sep - Oct;99:106594. doi: 10.1016/j.vascn.2019.106594. Epub 2019 May 31.

The standard infrared photobeam locomotor activity system has been used extensively in neurobiology and neuropharmacology to study the functional impact of direct manipulations of the nervous system. There is interest in using the activity monitors to assess the early...

Real estate diagrams: A tool to quickly assess the utility of a new predictive technology.

Journal of pharmacological and toxicological methods

Felli JC, Leishman DJ.
PMID: 31247306
J Pharmacol Toxicol Methods. 2019 Sep - Oct;99:106603. doi: 10.1016/j.vascn.2019.106603. Epub 2019 Jun 24.

INTRODUCTION: Scientists are increasingly in a position to ask whether or not to adopt new technologies. We present a visualization tool to help scientists swiftly evaluate the worth of new assays.METHODS: The parameters (prevalence, sensitivity and, specificity) relevant to...

Methodological and technological advances in safety pharmacology - New or simply nuanced?.

Journal of pharmacological and toxicological methods

Pugsley MK, de Korte T, Udupa V, Authier S, Curtis MJ.
PMID: 31254621
J Pharmacol Toxicol Methods. 2019 Sep - Oct;99:106604. doi: 10.1016/j.vascn.2019.106604. Epub 2019 Jun 27.

This editorial previews and summarizes the content of the current themed issue of J Pharm Tox Methods derived from the recent 2018 Annual Safety Pharmacology Society (SPS) meeting held in Washington, DC. The papers highlight improvements in methods and...

High-content imaging analysis for detecting the loss of drebrin clusters along dendrites in cultured hippocampal neurons.

Journal of pharmacological and toxicological methods

Hanamura K, Koganezawa N, Kamiyama K, Tanaka N, Oka T, Yamamura M, Sekino Y, Shirao T.
PMID: 31271780
J Pharmacol Toxicol Methods. 2019 Sep - Oct;99:106607. doi: 10.1016/j.vascn.2019.106607. Epub 2019 Jul 02.

INTRODUCTION: Detection of drug effects on neuronal synapses is important for predicting their adverse effects. We have used drebrin as a marker to detect the synaptic changes in cultured neurons. High concentration of glutamate decreases the amount of drebrin...

2019 Asia Pacific Conference on Medical and Health Science, 1-3 June 2019, Seoul, South Korea.

Basic & clinical pharmacology & toxicology

[No authors listed]
PMID: 31282106
Basic Clin Pharmacol Toxicol. 2019 Jul;125:3-224. doi: 10.1111/bcpt.13266.

No abstract available.

Showing 1 to 12 of 548 entries