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Showing 1 to 12 of 529 entries
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Royal Alexander Brink (1897-1984).

Genetics

Owen RD, Nelson OE.
PMID: 3510941
Genetics. 1986 Jan;112(1):1-10.

No abstract available.

Homozygosity for the V377I mutation in mevalonate kinase causes distinct clinical phenotypes in two sibs with hyperimmunoglobulinaemia D and periodic fever syndrome (HIDS).

RMD open

Messer L, Alsaleh G, Georgel P, Carapito R, Waterham HR, Dali-Youcef N, Bahram S, Sibilia J.
PMID: 26977311
RMD Open. 2016 Mar 07;2(1):e000196. doi: 10.1136/rmdopen-2015-000196. eCollection 2016.

OBJECTIVE: Mevalonate kinase (MVK) deficiency is a rare autosomal recessive auto-inflammatory disorder characterised by recurring episodes of fever associated with multiple non-specific inflammatory symptoms and caused by mutations in the MVK gene. The phenotypic spectrum is wide and depends...

Correction.

RMD open

[No authors listed]
PMID: 26629365
RMD Open. 2015 Oct 28;1(1):e000146corr1. doi: 10.1136/rmdopen-2015-000146corr1. eCollection 2015.

[This corrects the article DOI: 10.1136/rmdopen-2015-000146.].

Long-term study of the impact of methotrexate on serum cytokines and lymphocyte subsets in patients with active rheumatoid arthritis: correlation with pharmacokinetic measures.

RMD open

Kremer JM, Lawrence DA, Hamilton R, McInnes IB.
PMID: 27335660
RMD Open. 2016 Jun 09;2(1):e000287. doi: 10.1136/rmdopen-2016-000287. eCollection 2016.

OBJECTIVE: To describe changes in immune parameters observed during long-term methotrexate (MTX) therapy in patients with active rheumatoid arthritis (RA) and explore correlations with simultaneously measured MTX pharmacokinetic (PKC) parameters.DESIGN: Prospective, open-label, long-term mechanism of action study.SETTING: University clinic.METHODS:...

Influence of aromatase inhibitors therapy on the occurrence of rheumatoid arthritis in women with breast cancer: results from a large population-based study of the Italian Society for Rheumatology.

RMD open

Caprioli M, Carrara G, Sakellariou G, Silvagni E, Scirè CA.
PMID: 29071118
RMD Open. 2017 Sep 28;3(2):e000523. doi: 10.1136/rmdopen-2017-000523. eCollection 2017.

OBJECTIVES: The purpose of this study was to evaluate the risk of developing rheumatoid arthritis (RA) in a population of patients with breast cancer treated with aromatase inhibitors (AIs) compared with tamoxifen.METHODS: Data were collected from the administrative healthcare...

Achieving comprehensive disease control in patients with early and established rheumatoid arthritis treated with adalimumab plus methotrexate versus methotrexate alone.

RMD open

Keystone EC, Breedveld FC, van der Heijde D, van Vollenhoven RF, Emery P, Smolen JS, Sainsbury I, Florentinus S, Kupper H, Chen K, Kavanaugh A.
PMID: 29018564
RMD Open. 2017 Sep 26;3(2):e000445. doi: 10.1136/rmdopen-2017-000445. eCollection 2017.

OBJECTIVE: To evaluate the achievement of comprehensive disease control (CDC) following 1 year of treatment with adalimumab+methotrexate versus methotrexate alone and whether early achievement of remission (at week 24 or 26) is associated with CDC at week 52 in...

Do we need bone mineral density to estimate osteoporotic fracture risk? A 10-year prospective multicentre validation study.

RMD open

Marques A, Lucas R, Simões E, Verstappen SMM, Jacobs JWG, da Silva JAP.
PMID: 29018567
RMD Open. 2017 Sep 26;3(2):e000509. doi: 10.1136/rmdopen-2017-000509. eCollection 2017.

OBJECTIVE: Evaluate the performance of FRAX®, with and without bone mineral densitometry (BMD), in predicting the occurrence of fragility fractures over 10 years.METHODS: Participants aged ≥40 years at baseline, with a complete set of data and a minimum of...

Safety and efficacy of baricitinib in elderly patients with rheumatoid arthritis.

RMD open

Fleischmann R, Alam J, Arora V, Bradley J, Schlichting DE, Muram D, Smolen JS.
PMID: 29071120
RMD Open. 2017 Oct 10;3(2):e000546. doi: 10.1136/rmdopen-2017-000546. eCollection 2017.

No abstract available.

Socioeconomic inequities in perceived health among patients with musculoskeletal disorders compared with other chronic disorders: results from a cross-sectional Dutch study.

RMD open

Putrik P, Ramiro S, Chorus AM, Keszei AP, Boonen A.
PMID: 26535136
RMD Open. 2015 May 21;1(1):e000045. doi: 10.1136/rmdopen-2014-000045. eCollection 2015.

OBJECTIVES: To explore the impact of socioeconomic factors on physical and mental health of patients with musculoskeletal disorders (MSKDs) and compare it across patients with other disorders.METHODS: A representative sample of the Dutch population (n=8904) completed a survey on...

Longer durations of antitumour necrosis factor treatment are associated with reduced risk of cardiovascular events in patients with rheumatoid arthritis.

RMD open

Nurmohamed M, Bao Y, Signorovitch J, Trahey A, Mulani P, Furst DE.
PMID: 26535138
RMD Open. 2015 May 21;1(1):e000080. doi: 10.1136/rmdopen-2015-000080. eCollection 2015.

OBJECTIVE: To assess the effects of treatment with antitumour necrosis factor (TNF) agents, methotrexate, or other non-biological disease-modifying antirheumatic drugs (DMARDs) on cardiovascular event risks among patients with rheumatoid arthritis (RA).METHODS: We conducted a retrospective study using data from...

Biosimilars: what do patients need to consider?.

RMD open

Skingle D.
PMID: 26535149
RMD Open. 2015 Sep 16;1(1):e000141. doi: 10.1136/rmdopen-2015-000141. eCollection 2015.

A view from the EULAR Standing Committee of People with Arthritis/Rheumatism in Europe (SCPARE) on some of the issues that patients might wish to consider about biosimilars in shared decision-making discussions with their rheumatologist. The paper also points to...

Tapering and discontinuation of methotrexate in patients with RA treated with TNF inhibitors: data from the DREAM registry.

RMD open

Manders SH, van de Laar MA, Rongen-van Dartel SA, Bos R, Visser H, Brus HL, Jansen T, Vonkeman HE, van Riel PL, Kievit W.
PMID: 26535151
RMD Open. 2015 Oct 08;1(1):e000147. doi: 10.1136/rmdopen-2015-000147. eCollection 2015.

OBJECTIVES: To study the number of patients that taper or discontinue concomitant methotrexate (MTX) in daily practice in patients with rheumatoid arthritis (RA) treated with tumour necrosis factor inhibitor (TNFi) and to analyse the effects of that adaption on...

Showing 1 to 12 of 529 entries