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Biliary excretion of phenolphthalein glucuronide in the rat.

Hepatology research : the official journal of the Japan Society of Hepatology

Ogasawara T, Takikawa H.
PMID: 11348857
Hepatol Res. 2001 Jun;20(2):221-231. doi: 10.1016/s1386-6346(00)00143-1.

To examine the substrate specificity of an ATP-dependent organic anion transporter, the multidrug resistance protein 2, we examined the effects of various bile acid conjugates and organic anions on the biliary excretion of phenolphthalein glucuronide, a hydrophilic glucuronide conjugate,...

Evaluation of hepatic and renal function in cats with chediak-higashi syndrome.

Veterinary clinical pathology

Wardrop KJ, Dhein CR, Prieur DJ, Meyers KM.
PMID: 15221700
Vet Clin Pathol. 1987;16(2):40-4. doi: 10.1111/j.1939-165x.1987.tb00459.x.

Cats with the Chediak-Higashi Syndrome (CHS) have partial oculocutaneous albinism, a bleeding tendency, and enlarged cytoplasmic granules in many cell types including those in the liver and kidney. Hepatic and renal function was evaluated in six CHS and six...

Effect of dexamethasone on biliary excretion of bile acids and organic anions in rats.

Hepatology research : the official journal of the Japan Society of Hepatology

Suzuki C, Sano N, Takikawa H.
PMID: 12644038
Hepatol Res. 2003 Jan;25(1):48-54. doi: 10.1016/s1386-6346(02)00204-8.

Multidrug resistance protein 2 (Mrp2) is an important transporter for biliary excretion of organic anions, and is reported to be up-regulated by dexamethasone. In the present study, effect of dexamethazone (1 mg/kg) on biliary excretion of bile acids and...

The effect of age on the biliary transport maximum (Tm) of bile salts in rats.

Archives of gerontology and geriatrics

Kanai S, Sato Y, Kitani K.
PMID: 15374395
Arch Gerontol Geriatr. 1992 Mar-Apr;14(2):101-15. doi: 10.1016/0167-4943(92)90045-6.

Age-related differences in the biliary transport maxima (Tm) values for taurocholate (TC) and tauroursodeoxycholate (TUDC) were examined in female Fischer-344 rats as well as Wistar-derived rats of both sexes. The Tm values for TUDC were more than two times...

Effects of perfluoroalkyl carboxylic acids on the uptake of sulfobromophthalein via organic anion transporting polypeptides in human intestinal Caco-2 cells.

Biochemistry and biophysics reports

Kimura O, Fujii Y, Haraguchi K, Kato Y, Ohta C, Koga N, Endo T.
PMID: 32964147
Biochem Biophys Rep. 2020 Sep 07;24:100807. doi: 10.1016/j.bbrep.2020.100807. eCollection 2020 Dec.

We performed a detailed investigation of the uptake of sulfobromophthalein (BSP) from the apical membrane of Caco-2 cells, which is a substrate for organic anion transporting polypeptides (OATPs), and calculated the kinetic parameters of BSP uptake as follows: K

Reversible cholestasis induced by experimental partial obstruction of the bile duct; Biochemical, morphometric and hepatic transport kinetic studies.

Pathophysiology : the official journal of the International Society for Pathophysiology

Rodriguez-Garay EA, Rodríguez GP, Pisani G, Taborda M, Viglianco RA.
PMID: 15177510
Pathophysiology. 2004 Jul;11(1):7-15. doi: 10.1016/j.pathophys.2003.09.002.

The aim of this investigation was to reproduce in rats a partial stenosis of the common bile duct to analyze early liver functional and morphometric changes. The hepatic transport kinetics of sulfobromophthalein (organic anion) and rhodamine B (organic cation)...

Effect of cyclosporin A on the biliary excretion of cholephilic compounds in rats.

Hepatology research : the official journal of the Japan Society of Hepatology

Akashi M, Tanaka A, Takikawa H.
PMID: 16476567
Hepatol Res. 2006 Mar;34(3):193-8. doi: 10.1016/j.hepres.2005.08.013. Epub 2006 Feb 14.

Cyclosporin A (CsA) is known to cause cholestasis. CsA is reported to competitively inhibit the transport of the substrates of the bile salt export pump (Bsep), multidrug resistance protein 2 (Mrp2) and P-glycoprotein (P-gp) in the canalicular membrane vesicles....

Effects of feeding a high level of D-glucose on liver function in juvenile white sturgeon (Acipenser transmontanus).

Fish physiology and biochemistry

Fynn-Aikins K, Hung SS, Hughes SG.
PMID: 24202873
Fish Physiol Biochem. 1993 Dec;12(4):317-25. doi: 10.1007/BF00004416.

Juvenile white sturgeon (Acipenser transmontanus) were fed three isonitrogenous and isoenergetic diets containing either 35% D-glucose (HC), a mixture of 20% dextrin and 10% cellulose (MC), or 23% cellulose (LC), to investigate the effects of dietary carbohydrate on liver...

Effect of genipin on the biliary excretion of cholephilic compounds in rats.

Hepatology research : the official journal of the Japan Society of Hepatology

Mikami M, Takikawa H.
PMID: 18070051
Hepatol Res. 2008 Jun;38(6):614-21. doi: 10.1111/j.1872-034X.2007.00309.x. Epub 2007 Dec 09.

AIM: Genipin, a metabolite of geniposide, is reported to stimulate the insertion of multidrug resistance protein 2 (Mrp2) in the bile canalicular membrane, and to cause choleresis by increasing the biliary excretion of glutathione, which has been considered to...

The potential for an interaction between MRP2 (ABCC2) and various therapeutic agents: probenecid as a candidate inhibitor of the biliary excretion of irinotecan metabolites.

Drug metabolism and pharmacokinetics

Horikawa M, Kato Y, Tyson CA, Sugiyama Y.
PMID: 15618649
Drug Metab Pharmacokinet. 2002;17(1):23-33. doi: 10.2133/dmpk.17.23.

Irinotecan hydrochloride (CPT-11) is an anticancer agent with unpredictable bouts of diarrhea as a dose-limiting toxic side-effect. Since the biliary excretion of its active metabolite (SN-38) and SN-38 glucuronide (SN38-Glu), which are mediated by the multidrug resistance associated protein-2...

Solution properties of sulfobromophthalein sodium (BSP) compounds alone and in association with sodium taurocholate (TC).

The Journal of laboratory and clinical medicine

Ware AJ, Carey MC, Combes B.
PMID: 1249476
J Lab Clin Med. 1976 Mar;87(3):443-56.

A series of in vitro studies have been performed utilizing the techniques of ultracentrifugation, freezing point depression, vapor pressure osmometry, and spectrophotometry, to study the colloid-chemical characteristics of various sulfobromophthalein sodium (BSP) compounds in aqueous solution and to evaluate...

Showing 1 to 11 of 11 entries