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Showing 1 to 12 of 67 entries
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Methylation analysis by microarray.

Methods in molecular biology (Clifton, N.J.)

Deatherage DE, Potter D, Yan PS, Huang TH, Lin S.
PMID: 19488875
Methods Mol Biol. 2009;556:117-39. doi: 10.1007/978-1-60327-192-9_9.

Differential methylation hybridization (DMH) is a high-throughput DNA methylation screening tool that utilizes methylation-sensitive restriction enzymes to profile methylated fragments by hybridizing them to a CpG island microarray. This array contains probes spanning all the 27,800 islands annotated in...

Increasing the specificity and function of DNA microarrays by processing arrays at different stringencies.

Analytical and bioanalytical chemistry

Dufva M, Petersen J, Poulsen L.
PMID: 19495730
Anal Bioanal Chem. 2009 Oct;395(3):669-77. doi: 10.1007/s00216-009-2848-z. Epub 2009 Jun 03.

DNA microarrays have for a decade been the only platform for genome-wide analysis and have provided a wealth of information about living organisms. DNA microarrays are processed today under one condition only, which puts large demands on assay development...

DNA analysis using an integrated microchip for multiplex PCR amplification and electrophoresis for reference samples.

Analytical chemistry

Le Roux D, Root BE, Reedy CR, Hickey JA, Scott ON, Bienvenue JM, Landers JP, Chassagne L, de Mazancourt P.
PMID: 25091472
Anal Chem. 2014 Aug 19;86(16):8192-9. doi: 10.1021/ac501666b. Epub 2014 Aug 05.

A system that automatically performs the PCR amplification and microchip electrophoretic (ME) separation for rapid forensic short tandem repeat (STR) forensic profiling in a single disposable plastic chip is demonstrated. The microchip subassays were optimized to deliver results comparable...

Circular dichroism spectroscopy of DNA duplexes at near-biological concentrations.

Bioorganic & medicinal chemistry letters

Vanloon J, Harroun T, Yan H.
PMID: 33895278
Bioorg Med Chem Lett. 2021 Jul 01;43:128053. doi: 10.1016/j.bmcl.2021.128053. Epub 2021 Apr 22.

Circular dichroism (CD) of nucleic acids has been typically carried out at sample concentrations below 10 μM, which is far lower than nucleic acid concentrations in biological systems. Attempts to study nucleic acid conformations by CD at higher concentrations...

Additive manufacturing of laminar flow cells for single-molecule experiments.

Scientific reports

Ahmadi A, Till K, Hafting Y, Schüttpelz M, Bjørås M, Glette K, Tørresen J, Rowe AD, Dalhus B.
PMID: 31727950
Sci Rep. 2019 Nov 14;9(1):16784. doi: 10.1038/s41598-019-53151-z.

A microfluidic laminar flow cell (LFC) forms an indispensable component in single-molecule experiments, enabling different substances to be delivered directly to the point under observation and thereby tightly controlling the biochemical environment immediately surrounding single molecules. Despite substantial progress...

DNA-Based Population Screening: Potential Suitability and Important Knowledge Gaps.


Murray MF, Evans JP, Khoury MJ.
PMID: 31808788
JAMA. 2020 Jan 28;323(4):307-308. doi: 10.1001/jama.2019.18640.

No abstract available.

Label-free plasmonic assisted optical trapping of single DNA molecules.

Optics letters

Chen L, Liu W, Shen D, Zhou Z, Liu Y, Wan W.
PMID: 33720217
Opt Lett. 2021 Mar 15;46(6):1482-1485. doi: 10.1364/OL.420957.

DNA molecules are hard to catch using traditional optical trapping due to the nanometer width of their chains. Here we experimentally demonstrate a label-free optical trapping of a single micrometer

Microarrays: their origins and applications.

Trends in biotechnology

Ekins R, Chu FW.
PMID: 10354556
Trends Biotechnol. 1999 Jun;17(6):217-8. doi: 10.1016/s0167-7799(99)01329-3.

No abstract available.

[DNA diagnosis for eye diseases at the present time and in the future].

Nippon Ganka Gakkai zasshi

Mashima Y.
PMID: 11579583
Nippon Ganka Gakkai Zasshi. 2001 Sep;105(9):589-90.

No abstract available.

Computer chip speeds DNA analysis.

Analytical chemistry

[No authors listed]
PMID: 2757216
Anal Chem. 1989 Jul 15;61(14):834A. doi: 10.1021/ac00189a719.

No abstract available.

DNA typing is called flawed.

Science (New York, N.Y.)

Lewin R.
PMID: 2756424
Science. 1989 Jul 28;245(4916):355. doi: 10.1126/science.2756424.

No abstract available.

On the shape of a DNA molecule.

The Bulletin of mathematical biophysics

Wu TT.
PMID: 5963155
Bull Math Biophys. 1966 Jun;28(2):207-16. doi: 10.1007/BF02476995.

No abstract available.

Showing 1 to 12 of 67 entries