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Ned Tijdschr Geneeskd. 1991 Jun 15;135(24):1088-90.

[Fatal liver cell necrosis following administration of glafenine].

Nederlands tijdschrift voor geneeskunde

[Article in Dutch]
G H Koek, B H Stricker, R W Veldhuizen, P de Graaf


  1. Sint Antoniushove Ziekenhuis, Leidschendam.

PMID: 1677166


The case is described of a patient with fulminant hepatic failure attributed to intake of glafenine 400 mg daily for 15 days. The first symptoms appeared two weeks after discontinuation of glafenine. Other causes of hepatic necrosis could be excluded. Approximately five weeks after the onset of symptoms the patient died of hepatic failure. At autopsy massive hepatic necrosis and massive pancreatic necrosis were demonstrated.


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