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Transfus Med Hemother. 2011;38(3):195-198. doi: 10.1159/000328634. Epub 2011 May 11.

Platelet Recruitment during Multiple Donor Platelet Apheresis Differs between Cell Separators.

Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie

Stefano Fontana, Peter Keller, Behrouz Mansouri Taleghani

Affiliations

  1. Blood Transfusion Service of the Swiss Red Cross, Division of Transfusion Medicine, Inselspital, University Hospital, Bern, Switzerland.

PMID: 21760764 PMCID: PMC3128152 DOI: 10.1159/000328634

Abstract

SUMMARY: BACKGROUND: Recruitment of platelets (PLT) during donor PLT apheresis may facilitate the harvest of multiple units within a single donation. METHODS: We compared two PLT apheresis procedures (Amicus and Trima Accel) in a prospective, randomized, paired cross-over study in 60 donors. The 120 donations were compared for depletion of circulating PLT in the donors, PLT yields and PLT recruitment. A recruitment was defined as ratio of total PLT yield and donor PLT depletion > 1. RESULTS: Despite comparable differences of pre- and post-apheresis PLT counts (87 × 10(9)/l in Trima Accel vs. 92 × 10(9)/l in Amicus, p = 0.383), PLT yields were higher with Trima Accel (7.48 × 10(11) vs. 6.06 × 10(11), p < 0.001), corresponding to a higher PLT recruitment (1.90 vs. 1.42, p < 0.001). We observed a different increase of WBC counts after aphereses, which was more pronounced with Trima Accel than with Amicus (1.30 × 10(9)/l vs. 0.46 × 10(9)/l, p < 0.001). CONCLUSION: Both procedures induced PLT recruitment. This was higher in Trima Accel, contributing to a higher yield in spite of a comparable depletion of circulating PLT in the donors. This recruitment facilitates the harvest of multiple units within a single donation and seems to be influenced by the procedure utilized. The different increases of circulating donor white blood cells after donation need further investigation.

References

  1. Transfusion. 2006 Nov;46(11):2004-10 - PubMed
  2. Curr Opin Hematol. 2001 Nov;8(6):392-6 - PubMed
  3. Transfusion. 1985 May-Jun;25(3):215-8 - PubMed
  4. Transfusion. 2006 Aug;46(8):1408-16 - PubMed
  5. Am J Hematol. 1985 Jun;19(2):161-5 - PubMed
  6. Transfusion. 2010 Jun;50(6):1312-21 - PubMed
  7. Transfusion. 2008 Mar;48(3):442-50 - PubMed
  8. Transfusion. 2004 Nov;44(11):1612-20 - PubMed
  9. Transfusion. 2005 Aug;45(8):1373-81 - PubMed
  10. J Clin Apher. 1997;12(4):170-8 - PubMed
  11. Transfus Med Rev. 2006 Oct;20(4):273-82 - PubMed

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