Display options
Cite
Haeseker MB, Pijpers E, Dukers-Muijrers NH, et al. Association of cytomegalovirus and other pathogens with frailty and diabetes mellitus, but not with cardiovascular disease and mortality in psycho-geriatric patients; a prospective cohort study. Immun Ageing. 2013;10(1):30doi: 10.1186/1742-4933-10-30.
Haeseker, M. B., Pijpers, E., Dukers-Muijrers, N. H., Nelemans, P., Hoebe, C. J., Bruggeman, C. A., Verbon, A., & Goossens, V. J. (2013). Association of cytomegalovirus and other pathogens with frailty and diabetes mellitus, but not with cardiovascular disease and mortality in psycho-geriatric patients; a prospective cohort study. Immunity & ageing : I & A, 10(1), 30. https://doi.org/10.1186/1742-4933-10-30
Haeseker, Michiel B, et al. "Association of cytomegalovirus and other pathogens with frailty and diabetes mellitus, but not with cardiovascular disease and mortality in psycho-geriatric patients; a prospective cohort study." Immunity & ageing : I & A vol. 10,1 (2013): 30. doi: https://doi.org/10.1186/1742-4933-10-30
Haeseker MB, Pijpers E, Dukers-Muijrers NH, Nelemans P, Hoebe CJ, Bruggeman CA, Verbon A, Goossens VJ. Association of cytomegalovirus and other pathogens with frailty and diabetes mellitus, but not with cardiovascular disease and mortality in psycho-geriatric patients; a prospective cohort study. Immun Ageing. 2013 Jul 23;10(1):30. doi: 10.1186/1742-4933-10-30. PMID: 23880245; PMCID: PMC3726516.
Copy Download .nbib Format: NLM
Share it on

Immun Ageing. 2013 Jul 23;10(1):30. doi: 10.1186/1742-4933-10-30.

Association of cytomegalovirus and other pathogens with frailty and diabetes mellitus, but not with cardiovascular disease and mortality in psycho-geriatric patients; a prospective cohort study.

Immunity & ageing : I & A

Michiel B Haeseker, Evelien Pijpers, Nicole Htm Dukers-Muijrers, Patty Nelemans, Christian Jpa Hoebe, Cathrien A Bruggeman, Annelies Verbon, Valère J Goossens

Affiliations

  1. Department of Medical Microbiology, Maastricht University Medical Centre, P, Debyelaan 25, PO Box 5800, 6202 AZ Maastricht, the Netherlands. [email protected].

PMID: 23880245 PMCID: PMC3726516 DOI: 10.1186/1742-4933-10-30

Abstract

BACKGROUND: Studies about associations of infections with herpes viruses and other pathogens, such as Chlamydia pneumoniae (CP) and Helicobacter pylori (HP) with cardiovascular disease (CVD), diabetes mellitus (DM), frailty and/or mortality are conflicting. Since high levels of antibodies against these pathogens occur in the elderly, the role of these pathogens in morbidity and mortality of vulnerable elderly was explored.

RESULTS: Blood samples of 295 community dwelling psycho-geriatric patients were tested for IgG antibodies to herpes simplex virus type 1 and 2, varicella zoster virus, Epstein Barr virus (EBV), cytomegalovirus (CMV), human herpes virus type 6 (HHV6), CP and HP. Frailty was defined with an easy-to-use previously described frailty risk score. Relative risks (RR) with 95% confidence intervals were calculated to evaluate associations between CVD, DM, frailty and pathogens. Pathogens as a predictor for subsequent mortality were tested using Kaplan Meier analyses and Cox proportional hazard models. The mean age was 78 (SD: 6.7) years, 20% died, 44% were defined as frail, 20% had DM and 49% had CVD. Presence of CMV antibody titers was associated with frailty, as shown by using both qualitative and quantitative tests, RR ratio 1.4 (95% CI: 1.003-2.16) and RR ratio 1.5 (95% CI: 1.06-2.30), respectively. High IgG antibody titers of HHV6 and EBV were associated with DM, RR ratio 3.3 (95% CI: 1.57-6.49). None of the single or combined pathogens were significantly associated with mortality and/or CVD.

CONCLUSIONS: Prior CMV infection is associated with frailty, which could be in line with the concept that CMV might have an important role in immunosenescence, while high IgG titers of HHV6 and EBV are associated with DM. No association between a high pathogen burden and morbidity and/or mortality could be demonstrated.

References

  1. J Immunol. 1997 May 1;158(9):4493-9 - PubMed
  2. J Immunol. 2002 Aug 15;169(4):1984-92 - PubMed
  3. Vaccine. 2003 Sep 8;21(25-26):3826-36 - PubMed
  4. South Med J. 2005 Jul;98(7):686-92 - PubMed
  5. Heart. 1999 Mar;81(3):245-7 - PubMed
  6. Diabetes Care. 2005 Feb;28(2):435-6 - PubMed
  7. Ann N Y Acad Sci. 2009 Sep;1173:633-9 - PubMed
  8. Postgrad Med J. 2009 Sep;85(1007):464-9 - PubMed
  9. J Immunol. 2004 Dec 15;173(12):7481-9 - PubMed
  10. Trends Immunol. 2004 Aug;25(8):406-10 - PubMed
  11. Diabet Med. 2009 Feb;26(2):149-52 - PubMed
  12. Diabetes Care. 2006 May;29(5):1058-64 - PubMed
  13. JAMA. 2001 Jul 18;286(3):327-34 - PubMed
  14. J Am Geriatr Soc. 2005 May;53(5):747-54 - PubMed
  15. Exp Gerontol. 2002 Jan-Mar;37(2-3):445-53 - PubMed
  16. Clin Exp Immunol. 1994 Feb;95(2):287-93 - PubMed
  17. J Stroke Cerebrovasc Dis. 2007 Jul-Aug;16(4):145-52 - PubMed
  18. J Infect Dis. 2009 Nov 15;200(10):1606-10 - PubMed
  19. Rev Med Virol. 2009 Jan;19(1):47-56 - PubMed
  20. J Infect Dis. 1997 Apr;175(4):944-6 - PubMed
  21. JAMA. 2001 Mar 7;285(9):1153-4 - PubMed
  22. J Am Acad Dermatol. 2006 Feb;54(2 Suppl):S14-7 - PubMed
  23. J Infect Dis. 1989 Jul;160(1):1-10 - PubMed
  24. Circulation. 2002 Jan 1;105(1):15-21 - PubMed
  25. Epidemiol Infect. 1990 Apr;104(2):289-96 - PubMed
  26. Clin Immunol. 1999 Feb;90(2):213-9 - PubMed
  27. Med J Aust. 1974 Nov 9;2(19):706-7 - PubMed
  28. J Clin Microbiol. 1991 Jun;29(6):1215-20 - PubMed
  29. Circulation. 2001 Jan 2;103(1):45-51 - PubMed
  30. PLoS One. 2008;3(11):e3637 - PubMed
  31. Immun Ageing. 2012 Aug 28;9(1):18 - PubMed

Publication Types