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Friedman FM, Weiss JP. Desmopressin in the treatment of nocturia: clinical evidence and experience. Ther Adv Urol. 2013;5(6):310-7doi: 10.1177/1756287213502116.
Friedman, F. M., & Weiss, J. P. (2013). Desmopressin in the treatment of nocturia: clinical evidence and experience. Therapeutic advances in urology, 5(6), 310-7. https://doi.org/10.1177/1756287213502116
Friedman, Fara M, and Weiss, Jeffrey P. "Desmopressin in the treatment of nocturia: clinical evidence and experience." Therapeutic advances in urology vol. 5,6 (2013): 310-7. doi: https://doi.org/10.1177/1756287213502116
Friedman FM, Weiss JP. Desmopressin in the treatment of nocturia: clinical evidence and experience. Ther Adv Urol. 2013 Dec;5(6):310-7. doi: 10.1177/1756287213502116. PMID: 24294289; PMCID: PMC3825109.
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Ther Adv Urol. 2013 Dec;5(6):310-7. doi: 10.1177/1756287213502116.

Desmopressin in the treatment of nocturia: clinical evidence and experience.

Therapeutic advances in urology

Fara M Friedman, Jeffrey P Weiss

Affiliations

  1. Department of Urology, SUNY Downstate Medical Center, Brooklyn, NY, USA.

PMID: 24294289 PMCID: PMC3825109 DOI: 10.1177/1756287213502116

Abstract

Nocturia is a common and bothersome condition experienced by both men and women. Studies have suggested that nocturia contributes a level of morbidity to those who suffer from the condition, both young and old. Desmopressin has historically been utilized to treat conditions such as central diabetes insipidus, certain bleeding disorders and primary nocturnal enuresis. Recently, interest has increased as to the use of desmopressin (a vasopressin analog) in the treatment of adult nocturia, for whom nocturnal polyuria is prevalent. While desmopressin has been traditionally administered in tablet and bioequivalent high dose melt formulations, newer low-dose orally disintegrating sublingual desmopressin has been recently studied to determine safe and efficacious dosing strategies. In this review, nocturia and its associated morbidities are discussed, followed by a contemporary literature review regarding the safety and efficacy of desmopressin for its treatment.

Keywords: DDAVP; LUTS; desmopressin; nocturia; nocturnal polyuria

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