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Petchi RR, Parasuraman S, Vijaya C. Antidiabetic and antihyperlipidemic effects of an ethanolic extract of the whole plant of Tridax procumbens (Linn.) in streptozotocin-induced diabetic rats. J Basic Clin Pharm. 2013;4(4):88-92doi: 10.4103/0976-0105.121655.
Petchi, R. R., Parasuraman, S., & Vijaya, C. (2013). Antidiabetic and antihyperlipidemic effects of an ethanolic extract of the whole plant of Tridax procumbens (Linn.) in streptozotocin-induced diabetic rats. Journal of basic and clinical pharmacy, 4(4), 88-92. https://doi.org/10.4103/0976-0105.121655
Petchi, Ramesh R, et al. "Antidiabetic and antihyperlipidemic effects of an ethanolic extract of the whole plant of Tridax procumbens (Linn.) in streptozotocin-induced diabetic rats." Journal of basic and clinical pharmacy vol. 4,4 (2013): 88-92. doi: https://doi.org/10.4103/0976-0105.121655
Petchi RR, Parasuraman S, Vijaya C. Antidiabetic and antihyperlipidemic effects of an ethanolic extract of the whole plant of Tridax procumbens (Linn.) in streptozotocin-induced diabetic rats. J Basic Clin Pharm. 2013 Sep;4(4):88-92. doi: 10.4103/0976-0105.121655. PMID: 24808679; PMCID: PMC3979266.
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J Basic Clin Pharm. 2013 Sep;4(4):88-92. doi: 10.4103/0976-0105.121655.

Antidiabetic and antihyperlipidemic effects of an ethanolic extract of the whole plant of Tridax procumbens (Linn.) in streptozotocin-induced diabetic rats.

Journal of basic and clinical pharmacy

Ramesh R Petchi, S Parasuraman, C Vijaya

Affiliations

  1. Department of Pharmacology, Ultra College of Pharmacy, Madurai, Tamil Nadu, India.
  2. Pharmacology Unit, Faculty of Pharmacy, Asian Institute of Medicine, Science and Technology University, Bedong-Semeling Road, Bedong, 08100, Kedah, Malaysia.

PMID: 24808679 PMCID: PMC3979266 DOI: 10.4103/0976-0105.121655

Abstract

OBJECTIVE: To study the antidiabetic and antihyperlipidemic effects of an ethanolic extract of the whole plant of Tridax procumbens (Asteraceae) in streptozotocin-induced diabetic rats.

MATERIALS AND METHODS: The whole plant of T. procumbens was collected in different regions of Madurai districts, Tamil Nadu. The air dried whole plant of T. procumbens was extracted with ethanol (95%) in a Soxhlet apparatus for 72 h. Diabetes was induced in male Wistar rats by streptozotocin (50 mg/jk, i.p.) and nicotinamide (120 mg/kg, i.p) injection. The dry mass of the extract was used for preliminary phytochemical and pharmacological analysis. Diabetic rats were treated with glibenclamide (0.25 mg/kg, p.o.) or T. procumbens extract (250 and 500 mg/k, p.o.) for 21 consecutive days. The blood samples were collected at regular intervals to access hypoglycemic effect of an ethanolic extract of the whole plant of T. procumbens. At the end of the experiment, serum lipid profile and liver enzymes levels were analyzed for all the experimental animals and compared with diabetic control.

RESULTS: The preliminary phytochemical analysis of an ethanolic extract of the whole plant of T. procumbens indicated the presence of alkaloids, tannins, flavonoids, saponins, and phenolic compounds. The ethanolic extract of the whole plant of T. procumbens at 250 and 500 mg/kg has significant antidiabetic and antihyperlipidemic activities. The diabetic control animals exhibited a significant decrease in body weight compared with control animals. T. procumbens inhibited streptozotocin-induced weight loss and significantly alter the lipid levels.

CONCLUSION: The ethanolic extract of the whole plant of T. procumbens showed significant antidiabetic and antihyperlipidemic activities against streptozotocin-induced diabetes in rats.

Keywords: Antidiabetic; T. procumbens; antihyperlipidemic; diabetic mellitus; hyperlipidemia

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