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Landry MP, Kruss S, Nelson JT, et al. Experimental tools to study molecular recognition within the nanoparticle corona. Sensors (Basel). 2014;14(9):16196-211doi: 10.3390/s140916196.
Landry, M. P., Kruss, S., Nelson, J. T., Bisker, G., Iverson, N. M., Reuel, N. F., & Strano, M. S. (2014). Experimental tools to study molecular recognition within the nanoparticle corona. Sensors (Basel, Switzerland), 14(9), 16196-211. https://doi.org/10.3390/s140916196
Landry, Markita P, et al. "Experimental tools to study molecular recognition within the nanoparticle corona." Sensors (Basel, Switzerland) vol. 14,9 (2014): 16196-211. doi: https://doi.org/10.3390/s140916196
Landry MP, Kruss S, Nelson JT, Bisker G, Iverson NM, Reuel NF, Strano MS. Experimental tools to study molecular recognition within the nanoparticle corona. Sensors (Basel). 2014 Sep 02;14(9):16196-211. doi: 10.3390/s140916196. PMID: 25184487; PMCID: PMC4208170.
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Sensors (Basel). 2014 Sep 02;14(9):16196-211. doi: 10.3390/s140916196.

Experimental tools to study molecular recognition within the nanoparticle corona.

Sensors (Basel, Switzerland)

Markita P Landry, Sebastian Kruss, Justin T Nelson, Gili Bisker, Nicole M Iverson, Nigel F Reuel, Michael S Strano

Affiliations

  1. Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Ave. Cambridge, MA 02139, USA. [email protected].
  2. Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Ave. Cambridge, MA 02139, USA. [email protected].
  3. Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Ave. Cambridge, MA 02139, USA. [email protected].
  4. Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Ave. Cambridge, MA 02139, USA. [email protected].
  5. Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Ave. Cambridge, MA 02139, USA. [email protected].
  6. Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Ave. Cambridge, MA 02139, USA. [email protected].
  7. Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Ave. Cambridge, MA 02139, USA. [email protected].

PMID: 25184487 PMCID: PMC4208170 DOI: 10.3390/s140916196

Abstract

Advancements in optical nanosensor development have enabled the design of sensors using synthetic molecular recognition elements through a recently developed method called Corona Phase Molecular Recognition (CoPhMoRe). The synthetic sensors resulting from these design principles are highly selective for specific analytes, and demonstrate remarkable stability for use under a variety of conditions. An essential element of nanosensor development hinges on the ability to understand the interface between nanoparticles and the associated corona phase surrounding the nanosensor, an environment outside of the range of traditional characterization tools, such as NMR. This review discusses the need for new strategies and instrumentation to study the nanoparticle corona, operating in both in vitro and in vivo environments. Approaches to instrumentation must have the capacity to concurrently monitor nanosensor operation and the molecular changes in the corona phase. A detailed overview of new tools for the understanding of CoPhMoRe mechanisms is provided for future applications.

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