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Peng X, Wang W, Jiang C, et al. Strain-promoted oxidative annulation of arynes and cyclooctynes with benzamides: palladium-catalyzed C-H/N-H activation for the synthesis of N-heterocycles. Org Lett. 2014;16(20):5354-7doi: 10.1021/ol5025426.
Peng, X., Wang, W., Jiang, C., Sun, D., Xu, Z., & Tung, C. H. (2014). Strain-promoted oxidative annulation of arynes and cyclooctynes with benzamides: palladium-catalyzed C-H/N-H activation for the synthesis of N-heterocycles. Organic letters, 16(20), 5354-7. https://doi.org/10.1021/ol5025426
Peng, Xianglong, et al. "Strain-promoted oxidative annulation of arynes and cyclooctynes with benzamides: palladium-catalyzed C-H/N-H activation for the synthesis of N-heterocycles." Organic letters vol. 16,20 (2014): 5354-7. doi: https://doi.org/10.1021/ol5025426
Peng X, Wang W, Jiang C, Sun D, Xu Z, Tung CH. Strain-promoted oxidative annulation of arynes and cyclooctynes with benzamides: palladium-catalyzed C-H/N-H activation for the synthesis of N-heterocycles. Org Lett. 2014 Oct 17;16(20):5354-7. doi: 10.1021/ol5025426. Epub 2014 Oct 02. PMID: 25275617.
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Org Lett. 2014 Oct 17;16(20):5354-7. doi: 10.1021/ol5025426. Epub 2014 Oct 02.

Strain-promoted oxidative annulation of arynes and cyclooctynes with benzamides: palladium-catalyzed C-H/N-H activation for the synthesis of N-heterocycles.

Organic letters

Xianglong Peng, Weiguo Wang, Chao Jiang, Di Sun, Zhenghu Xu, Chen-Ho Tung

Affiliations

  1. Key Laboratory for Colloid and Interface Chemistry of Education Ministry, School of chemistry and Chemical Engineering, Shandong University , Jinan 250100, P.R. China.

PMID: 25275617 DOI: 10.1021/ol5025426

Abstract

Strained alkynes include arynes and cyclooctynes reacted with N-methoxyamides through palladium-catalyzed C-H/N-H activation for the first time. A variety of important N-heterocycles such as phenanthridinones and isoquinolones were constructed in one step with high efficiency.

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