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Chirteş F, Albu S. An overview of pharmacology and clinical aspects concerning the therapy of cochleo-vestibular syndromes by intratympanic drug delivery. Clujul Med. 2013;86(3):185-91
Chirteş, F., & Albu, S. (2013). An overview of pharmacology and clinical aspects concerning the therapy of cochleo-vestibular syndromes by intratympanic drug delivery. Clujul medical (1957), 86(3), 185-91.
Chirteş, Felician, and Albu, Silviu. "An overview of pharmacology and clinical aspects concerning the therapy of cochleo-vestibular syndromes by intratympanic drug delivery." Clujul medical (1957) vol. 86,3 (2013): 185-91.
Chirteş F, Albu S. An overview of pharmacology and clinical aspects concerning the therapy of cochleo-vestibular syndromes by intratympanic drug delivery. Clujul Med. 2013;86(3):185-91. Epub 2013 Aug 05. PMID: 26527944; PMCID: PMC4462510.
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Clujul Med. 2013;86(3):185-91. Epub 2013 Aug 05.

An overview of pharmacology and clinical aspects concerning the therapy of cochleo-vestibular syndromes by intratympanic drug delivery.

Clujul medical (1957)

Felician Chirteş, Silviu Albu

Affiliations

  1. ENT department, Military Hospital, Cluj-Napoca, Romania.
  2. Otolaryngology Head and Neck Surgery Department, Iuliu Ha?ieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.

PMID: 26527944 PMCID: PMC4462510

Abstract

Intratympanic drug delivery refers to drug administration in the middle ear, the main advantage being direct diffusion of substances in the inner ear through the round window membrane with subsequent high intralabiryntine drug concentration and very low systemic side effects. The article is a review of literature concerning the inner ear barrier systems, the physiology of inner ear fluids, intralabirinthine pharmacokinetics and the commonest drugs applied in the middle ear for the treatment of cochleo-vestibular syndromes.

Keywords: hemato-labirinthine barrier; intralabirinthine pharmacokinetics; intratympanic corticosteroids; intratympanic drug delivery; intratympanic gentamicine

References

  1. Hear Res. 1999 Feb;128(1-2):112-8 - PubMed
  2. Otolaryngol Head Neck Surg. 1999 May;120(5):643-8 - PubMed
  3. Laryngoscope. 1999 Jul;109(7 Pt 2):1-17 - PubMed
  4. Acta Otolaryngol Suppl. 1975;336:1-40 - PubMed
  5. Acta Otolaryngol. 2001 Jan;121(1):16-20 - PubMed
  6. Acta Otolaryngol. 2001 Jun;121(4):437-47 - PubMed
  7. Adv Otorhinolaryngol. 2002;59:140-8 - PubMed
  8. Otol Neurotol. 2002 Nov;23(6):967-74 - PubMed
  9. Laryngoscope. 2003 May;113(5):815-20 - PubMed
  10. Ann Otol Rhinol Laryngol. 1963 Sep;72:687-712 - PubMed
  11. Hear Res. 1992 Nov;63(1-2):37-42 - PubMed
  12. J Otolaryngol. 2003 Dec;32(6):351-61 - PubMed
  13. Arch Otolaryngol Head Neck Surg. 2004 May;130(5):518-23 - PubMed
  14. Acta Otolaryngol Suppl. 2004 Aug;(553):13-8 - PubMed
  15. Otolaryngol Clin North Am. 2004 Oct;37(5):973-90 - PubMed
  16. Otolaryngol Clin North Am. 2004 Oct;37(5):991-1000 - PubMed
  17. Otolaryngol Clin North Am. 2004 Oct;37(5):1075-90 - PubMed
  18. Otol Neurotol. 2004 Nov;25(6):1034-9 - PubMed
  19. Drug Discov Today. 2005 Oct 1;10(19):1299-306 - PubMed
  20. Physiol Genomics. 2006 Jan 12;24(2):114-23 - PubMed
  21. Hear Res. 2006 Feb;212(1-2):22-32 - PubMed
  22. Br J Pharmacol. 2006 Jan;147 Suppl 1:S258-68 - PubMed
  23. Int Tinnitus J. 2005;11(1):31-3 - PubMed
  24. Laryngoscope. 2006 Feb;116(2):201-6 - PubMed
  25. Otol Neurotol. 2006 Jun;27(4):564-9 - PubMed
  26. Ear Hear. 2006 Oct;27(5):457-65 - PubMed
  27. Otol Neurotol. 2006 Oct;27(7):912-7 - PubMed
  28. Volta Rev. 2005;105(3):277-298 - PubMed
  29. Hear Res. 1991 Nov;56(1-2):29-36 - PubMed
  30. Acta Otolaryngol. 2009 Feb;129(2):127-31 - PubMed
  31. Adv Drug Deliv Rev. 2008 Dec 14;60(15):1583-99 - PubMed
  32. Am J Physiol Cell Physiol. 2009 Mar;296(3):C544-57 - PubMed
  33. Otol Neurotol. 2009 Feb;30(2):131-8 - PubMed
  34. Otol Neurotol. 2011 Jan;32(1):29-35 - PubMed
  35. Neuroscience. 2011 Aug 11;188:157-67 - PubMed
  36. Otolaryngol Head Neck Surg. 2012 Mar;146(3 Suppl):S1-35 - PubMed
  37. Otol Neurotol. 2012 Sep;33(7):1257-65 - PubMed
  38. Am J Otolaryngol. 2013 Jul-Aug;34(4):296-300 - PubMed
  39. Hear Res. 1989 Nov;42(2-3):265-71 - PubMed
  40. Acta Otolaryngol Suppl. 1989;457:43-8 - PubMed
  41. Physiol Rev. 1988 Oct;68(4):1083-1128 - PubMed
  42. Hear Res. 1988 Sep 15;35(2-3):119-29 - PubMed
  43. Acta Otolaryngol Suppl. 1988;458:79-83 - PubMed
  44. Med J Osaka Univ. 1971 Mar;21(4):257-63 - PubMed
  45. Acta Otolaryngol. 1981 May-Jun;91(5-6):529-34 - PubMed
  46. Arch Otorhinolaryngol. 1980;228(1):29-34 - PubMed
  47. Otolaryngol Head Neck Surg. 1994 Sep;111(3 Pt 1):273-80 - PubMed
  48. Am J Otol. 1995 Mar;16(2):153-7 - PubMed
  49. Am J Physiol. 1997 Jan;272(1 Pt 1):C184-90 - PubMed
  50. Microsc Res Tech. 1997 Feb 1;36(3):201-11 - PubMed
  51. Hear Res. 1997 May;107(1-2):9-22 - PubMed
  52. Am J Otol. 1998 Mar;19(2):230-5 - PubMed

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