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Nath V, Baliga M. Urinary Bladder Adenocarcinoma Metastatic to the Abdominal Wall: Report of a Case with Cytohistologic Correlation. Case Rep Pathol. 2016;2016:8608412doi: 10.1155/2016/8608412.
Nath, V., & Baliga, M. (2016). Urinary Bladder Adenocarcinoma Metastatic to the Abdominal Wall: Report of a Case with Cytohistologic Correlation. Case reports in pathology, 20168608412. https://doi.org/10.1155/2016/8608412
Nath, Vikas, and Baliga, Mithra. "Urinary Bladder Adenocarcinoma Metastatic to the Abdominal Wall: Report of a Case with Cytohistologic Correlation." Case reports in pathology vol. 2016 (2016): 8608412. doi: https://doi.org/10.1155/2016/8608412
Nath V, Baliga M. Urinary Bladder Adenocarcinoma Metastatic to the Abdominal Wall: Report of a Case with Cytohistologic Correlation. Case Rep Pathol. 2016;2016:8608412. doi: 10.1155/2016/8608412. Epub 2016 Feb 23. PMID: 27006847; PMCID: PMC4781945.
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Case Rep Pathol. 2016;2016:8608412. doi: 10.1155/2016/8608412. Epub 2016 Feb 23.

Urinary Bladder Adenocarcinoma Metastatic to the Abdominal Wall: Report of a Case with Cytohistologic Correlation.

Case reports in pathology

Vikas Nath, Mithra Baliga

Affiliations

  1. Department of Pathology, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216, USA.

PMID: 27006847 PMCID: PMC4781945 DOI: 10.1155/2016/8608412

Abstract

We report a case of adenocarcinoma metastatic to the abdominal wall in a 71-year-old man with a history of primary bladder adenocarcinoma. CT-guided core biopsy was performed; imprints and histologic sections showed malignant glands lined by tumor cells with hyperchromatic nuclei and prominent nucleoli, infiltrating through skeletal muscle. Immunohistochemistry revealed positivity for CK7, membranous/cytoplasmic β-catenin, caudal-type homeobox transcription factor 2 (CDX2), and α-methylacyl coenzyme A racemase and negativity for CK20, p63, prostate-specific antigen (PSA), and prostate-specific acid phosphatase (PSAP). These findings were interpreted as metastatic adenocarcinoma, consistent with bladder primary. Primary bladder adenocarcinoma is a rare malignancy arising within glandular metaplasia and is associated with cystitis cystica and cystitis glandularis. Predisposing factors include bladder exstrophy, schistosomiasis, and other causes of chronic bladder irritation. This tumor is divided into intestinal, clear cell, and signet ring cell subtypes. Treatment involves radical cystectomy with pelvic lymph node dissection, and prognosis is unfavorable. Primary bladder adenocarcinoma should be differentiated from urachal adenocarcinoma, which arises from urachal remnants near the bladder dome, and secondary adenocarcinoma, or vesical involvement by adenocarcinoma from a different primary. CK7, CK20, CDX2, thrombomodulin, and β-catenin can help distinguish primary bladder adenocarcinoma from colonic adenocarcinoma; PSA and PSAP can help distinguish primary bladder adenocarcinoma from prostate adenocarcinoma.

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