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Tao W, Dong X, Kong G, et al. Elevated Circulating hsa-miR-106b, hsa-miR-26a, and hsa-miR-29b in Type 2 Diabetes Mellitus with Diarrhea-Predominant Irritable Bowel Syndrome. Gastroenterol Res Pract. 2016;2016:9256209doi: 10.1155/2016/9256209.
Tao, W., Dong, X., Kong, G., Fang, P., Huang, X., & Bo, P. (2016). Elevated Circulating hsa-miR-106b, hsa-miR-26a, and hsa-miR-29b in Type 2 Diabetes Mellitus with Diarrhea-Predominant Irritable Bowel Syndrome. Gastroenterology research and practice, 20169256209. https://doi.org/10.1155/2016/9256209
Tao, Wenhua, et al. "Elevated Circulating hsa-miR-106b, hsa-miR-26a, and hsa-miR-29b in Type 2 Diabetes Mellitus with Diarrhea-Predominant Irritable Bowel Syndrome." Gastroenterology research and practice vol. 2016 (2016): 9256209. doi: https://doi.org/10.1155/2016/9256209
Tao W, Dong X, Kong G, Fang P, Huang X, Bo P. Elevated Circulating hsa-miR-106b, hsa-miR-26a, and hsa-miR-29b in Type 2 Diabetes Mellitus with Diarrhea-Predominant Irritable Bowel Syndrome. Gastroenterol Res Pract. 2016;2016:9256209. doi: 10.1155/2016/9256209. Epub 2016 Aug 22. PMID: 27635130; PMCID: PMC5011218.
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Gastroenterol Res Pract. 2016;2016:9256209. doi: 10.1155/2016/9256209. Epub 2016 Aug 22.

Elevated Circulating hsa-miR-106b, hsa-miR-26a, and hsa-miR-29b in Type 2 Diabetes Mellitus with Diarrhea-Predominant Irritable Bowel Syndrome.

Gastroenterology research and practice

Wenhua Tao, Xiaoyun Dong, Guimei Kong, Penghua Fang, Xiaoli Huang, Ping Bo

Affiliations

  1. Jiangsu Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Senile Diseases, Medical School of Yangzhou University, No. 11 Huaihai Road, Yangzhou, Jiangsu 225001, China.

PMID: 27635130 PMCID: PMC5011218 DOI: 10.1155/2016/9256209

Abstract

Background and Aims. Although the differential expression of microRNA (miRNA) genes has been identified in many diseases, little information exists concerning the miRNA expression profile in type 2 diabetes mellitus (T2DM) with diarrhea-predominant irritable bowel syndrome (D-IBS). Therefore, the specific expression of miRNAs in diabetes with D-IBS is identified in the study. Materials and Methods. 201 patients with IBS and 220 matched healthy controls were included in the study. Microarray technology and real-time reverse transcriptase-polymerase chain reaction analysis (RT-PCR) were taken to examine the miRNA expression profiles of T2DM patients with diarrhea-predominant irritable bowel syndrome (D-IBS) compared with patients with T2DM, patients with D-IBS, and control subjects. Results. We have found that 35 miRNAs were differentially expressed in T2DM with D-IBS, in which three representative miRNAs, hsa-miR-106b, hsa-miR-26a, and hsa-miR-29b, were found to be significantly elevated in T2DM with D-IBS by RT-PCR. Conclusions. Our study has indicated that hsa-miR-106b, hsa-miR-26a, and hsa-miR-29b were elevated in T2DM with D-IBS, which may be the potential biomarkers of T2DM with D-IBS. To obtain a better understanding of the biological functions of these miRNAs in T2DM with D-IBS, functional annotation analysis suggested that the MAPK pathway may be responsible for T2DM with D-IBS.

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