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Lagarde M, Calzada C, Guichardant M, et al. In vitro and in vivo bimodal effects of docosahexaenoic acid supplements on redox status and platelet function. Prostaglandins Leukot Essent Fatty Acids. 2016;138:60-63doi: 10.1016/j.plefa.2016.05.010.
Lagarde, M., Calzada, C., Guichardant, M., & Véricel, E. (2018). In vitro and in vivo bimodal effects of docosahexaenoic acid supplements on redox status and platelet function. Prostaglandins, leukotrienes, and essential fatty acids, 13860-63. https://doi.org/10.1016/j.plefa.2016.05.010
Lagarde, Michel, et al. "In vitro and in vivo bimodal effects of docosahexaenoic acid supplements on redox status and platelet function." Prostaglandins, leukotrienes, and essential fatty acids vol. 138 (2018): 60-63. doi: https://doi.org/10.1016/j.plefa.2016.05.010
Lagarde M, Calzada C, Guichardant M, Véricel E. In vitro and in vivo bimodal effects of docosahexaenoic acid supplements on redox status and platelet function. Prostaglandins Leukot Essent Fatty Acids. 2018 Nov;138:60-63. doi: 10.1016/j.plefa.2016.05.010. Epub 2016 Jul 14. PMID: 27514724.
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Prostaglandins Leukot Essent Fatty Acids. 2018 Nov;138:60-63. doi: 10.1016/j.plefa.2016.05.010. Epub 2016 Jul 14.

In vitro and in vivo bimodal effects of docosahexaenoic acid supplements on redox status and platelet function.

Prostaglandins, leukotrienes, and essential fatty acids

Michel Lagarde, Catherine Calzada, Michel Guichardant, Evelyne Véricel

Affiliations

  1. Lyon University, Inserm UMR 1060, Inra UMR 1397 (CarMeN Laboratory), IMBL, INSA-Lyon, Villeurbanne, France. Electronic address: [email protected].
  2. Lyon University, Inserm UMR 1060, Inra UMR 1397 (CarMeN Laboratory), IMBL, INSA-Lyon, Villeurbanne, France.

PMID: 27514724 DOI: 10.1016/j.plefa.2016.05.010

Abstract

Docosahexaenoic acid (DHA) is a prominent nutrient of marine lipids. Together with eicosapentaenoic acid, it is recognized as a protective molecule against atherosclerosis and thrombosis through the regulation of blood cell functions, especially platelets. Its high unsaturation index may however make it prone to peroxidation, which is usually considered as deleterious. This short review takes into consideration this possibility related to DHA concentrations both in vitro and in vivo. It is suggested that protective effects of DHA on platelet activation depend on the reduction of oxidative stress, and appear bimodal with the abolishment of such a protection when DHA is used at relatively high concentrations.

Copyright © 2016 Elsevier Ltd. All rights reserved.

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