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Miyata T, Uesaka K, Nakanuma Y. Cystic and Papillary Neoplasm at the Hepatic Hilum Possibly Originating in the Peribiliary Glands. Case Rep Pathol. 2016;2016:9130754doi: 10.1155/2016/9130754.
Miyata, T., Uesaka, K., & Nakanuma, Y. (2016). Cystic and Papillary Neoplasm at the Hepatic Hilum Possibly Originating in the Peribiliary Glands. Case reports in pathology, 20169130754. https://doi.org/10.1155/2016/9130754
Miyata, Takashi, et al. "Cystic and Papillary Neoplasm at the Hepatic Hilum Possibly Originating in the Peribiliary Glands." Case reports in pathology vol. 2016 (2016): 9130754. doi: https://doi.org/10.1155/2016/9130754
Miyata T, Uesaka K, Nakanuma Y. Cystic and Papillary Neoplasm at the Hepatic Hilum Possibly Originating in the Peribiliary Glands. Case Rep Pathol. 2016;2016:9130754. doi: 10.1155/2016/9130754. Epub 2016 Aug 31. PMID: 27656307; PMCID: PMC5021872.
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Case Rep Pathol. 2016;2016:9130754. doi: 10.1155/2016/9130754. Epub 2016 Aug 31.

Cystic and Papillary Neoplasm at the Hepatic Hilum Possibly Originating in the Peribiliary Glands.

Case reports in pathology

Takashi Miyata, Katsuhiko Uesaka, Yasuni Nakanuma

Affiliations

  1. Division of Hepato-Biliary-Pancreatic Surgery, Shizuoka Cancer Center, Shizuoka, Japan; Division of Diagnostic Pathology, Shizuoka Cancer Center, Shizuoka, Japan.
  2. Division of Hepato-Biliary-Pancreatic Surgery, Shizuoka Cancer Center, Shizuoka, Japan.
  3. Division of Diagnostic Pathology, Shizuoka Cancer Center, Shizuoka, Japan.

PMID: 27656307 PMCID: PMC5021872 DOI: 10.1155/2016/9130754

Abstract

Cystic neoplasms of the liver are divided into two types: mucinous cystic neoplasm and cystic intraductal papillary neoplasm of the bile duct. We herein report two cases of cystic and papillary neoplasm of the liver which differed from the abovementioned types. Case  1. A 70-year-old man. Radiologically, a cystic tumor measuring 20 mm in diameter was found at the hepatic hilum. Right hepatectomy was performed under a diagnosis of intrahepatic cholangiocarcinoma (iCCA) based on the imaging findings. Case  2. A 70-year-old man. Radiologically, a cystic tumor measuring 60 mm in diameter was found at the hepatic hilum. Under a diagnosis of iCCA, left hepatic trisectionectomy was performed. In both cases, endoscopic retrograde cholangiography did not demonstrate communication between the cystic tumor and adjacent bile ducts. Pathologically, these two tumors were cystic neoplasms located at the hepatic hilum and were morphologically characterized by an intracystic papillary neoplasm composed of diffuse high-grade dysplasia and associated with an invasive carcinoma. Ovarian-like stroma was not found in the capsule of these tumors. Interestingly, there were peribiliary glands near these tumors, and MUC6 was expressed in these papillary neoplasms as well as in the peribiliary glands. These neoplasms might have arisen from the peribiliary glands.

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