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Front Neurol. 2016 Dec 22;7:233. doi: 10.3389/fneur.2016.00233. eCollection 2016.

Zika Virus Infection and Guillain-Barré Syndrome in Three Patients from Suriname.

Frontiers in neurology

Thomas Langerak, Harvey Yang, Mark Baptista, Laura Doornekamp, Tessa Kerkman, John Codrington, Jimmy Roosblad, Stephen G S Vreden, Erwin De Bruin, Ramona Mögling, Bart C Jacobs, Suzan D Pas, Corine H GeurtsvanKessel, Chantal B E M Reusken, Marion P Koopmans, Eric C M Van Gorp, Henk Alberga

Affiliations

  1. Department of Viroscience, Erasmus Medical Center , Rotterdam , Netherlands.
  2. Department of Neurology, Academic Hospital Paramaribo , Paramaribo , Suriname.
  3. Department of Neurology, St. Vincentius Hospital , Paramaribo , Suriname.
  4. Diagnostic Laboratory, Academic Hospital Paramaribo , Paramaribo , Suriname.
  5. Department of Internal Medicine, Academic Hospital Paramaribo , Paramaribo , Suriname.
  6. Department of Neurology, Erasmus Medical Center, Rotterdam, Netherlands; Department of Immunology, Erasmus Medical Center, Rotterdam, Netherlands.

PMID: 28066317 PMCID: PMC5177614 DOI: 10.3389/fneur.2016.00233

Abstract

We present three patients from Suriname who were diagnosed with Guillain-Barré syndrome (GBS) during the Zika virus (ZIKV) outbreak in this country. One patient had a positive ZIKV urine real-time RT-PCR (qRT-PCR) result. The other two patients had a negative ZIKV urine qRT-PCR but a positive virus neutralization test and presence of IgG antibodies against ZIKV in the serum. Considering the evidence of a past ZIKV infection and absence of evidence for recent infections with the most common preceding infections of GBS, it is very likely that these GBS cases were triggered by ZIKV.

Keywords: Flavivirus infections; Guillain–Barré syndrome; Zika virus; acute flaccid paralysis; emerging infectious disease

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