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AAPS PharmSciTech. 2006 Sep;7(3):E178-E183. doi: 10.1208/pt070378. Epub 2017 Mar 08.

Once-daily tablet formulation and in vitro release evaluation of cefpodoxime using hydroxypropyl methylcellulose: A technical note.

AAPS PharmSciTech

Hamid A Merchant, Harris M Shoaib, Jaweria Tazeen, Rabia I Yousuf


  1. Faculty of Pharmacy, University Road, 75270, Karachi, Pakistan.
  2. Faculty of Pharmacy, University Road, 75270, Karachi, Pakistan. [email protected].

PMID: 28290013 DOI: 10.1208/pt070378


Decreasing the dose frequency of cefpodoxime proxetil increases patient compliance; patients prefer to take the drug once daily. It also improves the rate of bacterial killing and hastens the cure from the indications, and therefore increases compliance. The hydrophilic matrix of HPMC controlled the cefpodoxime proxetil release effectively for 24 hours; hence, the formulation can be considered as a once-daily sustained-release tablet of cefpodoxime proxetil. The formulation showed acceptable pharmacotechnical properties and assay requirements. In vitro dissolution studies indicated a sustained-release pattern throughout 24 hours of the study that was comparable to the theoretical release profile. Drug release kinetics indicated that drug release was best explained by Higuchi's equation, as these plots showed the highest linearity (r

Keywords: Cefpo SR; Cefpodoxime proxetil; hydrophilic matrix tablets; hydroxypropyl methylcellulose (HPMC); in vitro sustained drug release; once-daily tablet

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