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Kumaran MS, Mangal S, Narang T, et al. Autologous Serum and Plasma Skin Tests in Chronic Spontaneous Urticaria: A Reappraisal. Indian Dermatol Online J. 2017;8(2):94-99doi: 10.4103/2229-5178.202266.
Kumaran, M. S., Mangal, S., Narang, T., & Parsad, D. (2017). Autologous Serum and Plasma Skin Tests in Chronic Spontaneous Urticaria: A Reappraisal. Indian dermatology online journal, 8(2), 94-99. https://doi.org/10.4103/2229-5178.202266
Kumaran, Muthu Sendhil, et al. "Autologous Serum and Plasma Skin Tests in Chronic Spontaneous Urticaria: A Reappraisal." Indian dermatology online journal vol. 8,2 (2017): 94-99. doi: https://doi.org/10.4103/2229-5178.202266
Kumaran MS, Mangal S, Narang T, Parsad D. Autologous Serum and Plasma Skin Tests in Chronic Spontaneous Urticaria: A Reappraisal. Indian Dermatol Online J. 2017 Mar-Apr;8(2):94-99. doi: 10.4103/2229-5178.202266. PMID: 28405547; PMCID: PMC5372454.
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Indian Dermatol Online J. 2017 Mar-Apr;8(2):94-99. doi: 10.4103/2229-5178.202266.

Autologous Serum and Plasma Skin Tests in Chronic Spontaneous Urticaria: A Reappraisal.

Indian dermatology online journal

Muthu Sendhil Kumaran, Sonia Mangal, Tarun Narang, Davinder Parsad

Affiliations

  1. Department of Dermatology, Venereology and Leprology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

PMID: 28405547 PMCID: PMC5372454 DOI: 10.4103/2229-5178.202266

Abstract

AIM: The objective of this study was to assess autologous serum skin test (ASST) vs autologous plasma skin test (APST) response in chronic spontaneous urticaria (CSU) patients and study the significance of intensity of positive responses in relation to clinicoepidemiological parameters.

MATERIALS AND METHODS: One hundred CSU patients and 100 age and sex-matched controls were recruited. The demographic and clinical features were recorded in all patients and routine investigations were performed. ASST and APST tests were performed as per the standard guidelines.

RESULTS: The mean duration of illness was 4.85 ± 5.07 years, 90% patients were APST (+), 68% ASST (+), and 22 patients were only APST (+). Positive predictive value (PPV) of ASST and APST was 90.7% and 95.7%, respectively. A significant inverse association was seen between thyroid status and serum IgE levels with APST and ASST positivity.

CONCLUSION: APST appears to have better PPV and high intensity of positive response on autologous tests, and correlates with ANA positivity and angioedema.

Keywords: Autoimmune; autologous plasma skin test; autologous serum skin test; chronic sponataneous urticaria

Conflict of interest statement

There are no conflicts of interest.

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