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United European Gastroenterol J. 2017 Oct;5(6):898-907. doi: 10.1177/2050640617692268. Epub 2017 Jan 31.

Transglucosidase improves the bowel movements in type 2 diabetes mellitus patients: A preliminary randomized double-blind, placebo-controlled study.

United European gastroenterology journal

Akihiro Shimozato, Makoto Sasaki, Naotaka Ogasawara, Yasushi Funaki, Masahide Ebi, Chiho Goto, Satoshi Koikeda, Takashi Joh, Kunio Kasugai

Affiliations

  1. Department of Gastroenterology, Aichi Medical University School of Medicine, Nagakute, Japan.
  2. Department of Health and Nutrition, Faculty of Health and Human Life, Nagoya Bunri University, Inazawa, Japan.
  3. Department of Frontier Research, Amano Enzyme Inc., Kakamigahara, Japan.
  4. Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.

PMID: 29026604 PMCID: PMC5625877 DOI: 10.1177/2050640617692268

Abstract

BACKGROUND: Recent studies have highlighted the relationship between gut microbiota and bowel movements.

OBJECTIVE: We aimed to evaluate transglucosidase treatment efficacy for bowel movements in patients with type 2 diabetes mellitus and to clarify the relationship between bowel movements, dietary habits, gut microbiota and fecal short-chain fatty acids.

METHODS: In this randomized double-blind, placebo-controlled study, 66 patients received placebo or transglucosidase (300 or 900 mg/day) orally, for 12 weeks. Fecal bacterial communities and short-chain fatty acids were analyzed before and after the treatment.

RESULTS: Transglucosidase treatment significantly (

CONCLUSION: Patients with bowel movement disorder suffer from gut dysbiosis. Transglucosidase treatment alleviates bowel movement disorder symptoms in type 2 diabetes mellitus patients by increasing fecal acetate level.

Keywords: Transglucosidase; bowel movements; constipation; intestinal microbiota; short-chain fatty acids; type 2 diabetes mellitus

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