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Almansa R, Martínez-Orellana P, Rico L, et al. Pulmonary transcriptomic responses indicate a dual role of inflammation in pneumonia development and viral clearance during 2009 pandemic influenza infection. PeerJ. 2017;5:e3915doi: 10.7717/peerj.3915.
Almansa, R., Martínez-Orellana, P., Rico, L., Iglesias, V., Ortega, A., Vidaña, B., Martínez, J., Expósito, A., Montoya, M., & Bermejo-Martin, J. F. (2017). Pulmonary transcriptomic responses indicate a dual role of inflammation in pneumonia development and viral clearance during 2009 pandemic influenza infection. PeerJ, 5e3915. https://doi.org/10.7717/peerj.3915
Almansa, Raquel, et al. "Pulmonary transcriptomic responses indicate a dual role of inflammation in pneumonia development and viral clearance during 2009 pandemic influenza infection." PeerJ vol. 5 (2017): e3915. doi: https://doi.org/10.7717/peerj.3915
Almansa R, Martínez-Orellana P, Rico L, Iglesias V, Ortega A, Vidaña B, Martínez J, Expósito A, Montoya M, Bermejo-Martin JF. Pulmonary transcriptomic responses indicate a dual role of inflammation in pneumonia development and viral clearance during 2009 pandemic influenza infection. PeerJ. 2017 Oct 11;5:e3915. doi: 10.7717/peerj.3915. eCollection 2017. PMID: 29038764; PMCID: PMC5640978.
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PeerJ. 2017 Oct 11;5:e3915. doi: 10.7717/peerj.3915. eCollection 2017.

Pulmonary transcriptomic responses indicate a dual role of inflammation in pneumonia development and viral clearance during 2009 pandemic influenza infection.

PeerJ

Raquel Almansa, Pamela Martínez-Orellana, Lucía Rico, Verónica Iglesias, Alicia Ortega, Beatriz Vidaña, Jorge Martínez, Ana Expósito, María Montoya, Jesús F Bermejo-Martin

Affiliations

  1. Laboratory of Biomedical Research in Sepsis (BIOSEPSIS), Hospital Clínico Universitario de Valladolid, Instituto de Estudios de Ciencias de la Salud de Castilla y León (IECSCYL), Valladolid, Spain.
  2. Centre de Recerca en Sanitat Animal (CReSA), Universitat Autónoma de Barcelona, IRTA, Barcelona, Spain.
  3. Department of Pathology, Animal and Plant Health Agency (APHA), Surrey, UK.
  4. Departament de Sanitat i d'Anatomia Animals, Universitat Autónoma de Barcelona, Barcelona, Spain.
  5. African Swine Fever Virus Immunology Group, The Pirbright Institute, Surrey, UK.

PMID: 29038764 PMCID: PMC5640978 DOI: 10.7717/peerj.3915

Abstract

BACKGROUND: The interaction between influenza virus and the host response to infection clearly plays an important role in determining the outcome of infection. While much is known on the participation of inflammation on the pathogenesis of severe A (H1N1) pandemic 09-influenza virus, its role in the course of non-fatal pneumonia has not been fully addressed.

METHODS: A systems biology approach was used to define gene expression profiles, histology and viral dynamics in the lungs of healthy immune-competent mice with pneumonia caused by a human influenza A (H1N1) pdm09 virus, which successfully resolved the infection.

RESULTS: Viral infection activated a marked pro-inflammatory response at the lung level paralleling the emergence of histological changes. Cellular immune response and cytokine signaling were the two signaling pathway categories more representative of our analysis. This transcriptome response was associated to viral clearance, and its resolution was accompanied by resolution of histopathology.

DISCUSSION: These findings suggest a dual role of pulmonary inflammation in viral clearance and development of pneumonia during non-fatal infection caused by the 2009 pandemic influenza virus. Understanding the dynamics of the host's transcriptomic and virological changes over the course of the infection caused by A (H1N1) pdm09 virus may help identifying the immune response profiles associated with an effective response against influenza virus.

Keywords: Gene expression; Immune response; Inflammation; Influenza; Lung; Mice model

Conflict of interest statement

The authors declare that they have no competing interests.

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