Display options
Cite
Morrison JL, Botting KJ, Darby JRT, et al. Guinea pig models for translation of the developmental origins of health and disease hypothesis into the clinic. J Physiol. 2018;596(23):5535-5569doi: 10.1113/JP274948.
Morrison, J. L., Botting, K. J., Darby, J. R. T., David, A. L., Dyson, R. M., Gatford, K. L., Gray, C., Herrera, E. A., Hirst, J. J., Kim, B., Kind, K. L., Krause, B. J., Matthews, S. G., Palliser, H. K., Regnault, T. R. H., Richardson, B. S., Sasaki, A., Thompson, L. P., & Berry, M. J. (2018). Guinea pig models for translation of the developmental origins of health and disease hypothesis into the clinic. The Journal of physiology, 596(23), 5535-5569. https://doi.org/10.1113/JP274948
Morrison, Janna L, et al. "Guinea pig models for translation of the developmental origins of health and disease hypothesis into the clinic." The Journal of physiology vol. 596,23 (2018): 5535-5569. doi: https://doi.org/10.1113/JP274948
Morrison JL, Botting KJ, Darby JRT, David AL, Dyson RM, Gatford KL, Gray C, Herrera EA, Hirst JJ, Kim B, Kind KL, Krause BJ, Matthews SG, Palliser HK, Regnault TRH, Richardson BS, Sasaki A, Thompson LP, Berry MJ. Guinea pig models for translation of the developmental origins of health and disease hypothesis into the clinic. J Physiol. 2018 Dec;596(23):5535-5569. doi: 10.1113/JP274948. Epub 2018 May 30. PMID: 29633280; PMCID: PMC6265540.
Copy Download .nbib Format: NLM
Share it on

J Physiol. 2018 Dec;596(23):5535-5569. doi: 10.1113/JP274948. Epub 2018 May 30.

Guinea pig models for translation of the developmental origins of health and disease hypothesis into the clinic.

The Journal of physiology

Janna L Morrison, Kimberley J Botting, Jack R T Darby, Anna L David, Rebecca M Dyson, Kathryn L Gatford, Clint Gray, Emilio A Herrera, Jonathan J Hirst, Bona Kim, Karen L Kind, Bernardo J Krause, Stephen G Matthews, Hannah K Palliser, Timothy R H Regnault, Bryan S Richardson, Aya Sasaki, Loren P Thompson, Mary J Berry

Affiliations

  1. Early Origins of Adult Health Research Group, School of Pharmacy and Medical Sciences, Sansom Institute for Health Research, University of South Australia, Adelaide, South Australia, Australia.
  2. Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK.
  3. Research Department of Maternal Fetal Medicine, Institute for Women's Health, University College London, London, UK.
  4. Department of Paediatrics & Child Health and Centre for Translational Physiology, University of Otago, Wellington, New Zealand.
  5. Robinson Research Institute and Adelaide Medical School, University of Adelaide, Adelaide, South Australia, Australia.
  6. Pathophysiology Program, Biomedical Sciences Institute (ICBM), Faculty of Medicine, University of Chile, Santiago, Chile.
  7. Mothers and Babies Research Centre, Hunter Medical Research Institute, School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, New South Wales, Australia.
  8. Department of Physiology, University of Toronto, Toronto, Ontario, Canada.
  9. School of Animal and Veterinary Sciences, University of Adelaide, Adelaide, South Australia, Australia.
  10. Division of Paediatrics, Faculty of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.
  11. Departments of Obstetrics and Gynaecology, Physiology and Pharmacology, Western University, and Children's Health Research Institute and Lawson Health Research Institute, London, Ontario, Canada.
  12. Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Maryland School of Medicine, Baltimore, MD, USA.

PMID: 29633280 PMCID: PMC6265540 DOI: 10.1113/JP274948

Abstract

Over 30 years ago Professor David Barker first proposed the theory that events in early life could explain an individual's risk of non-communicable disease in later life: the developmental origins of health and disease (DOHaD) hypothesis. During the 1990s the validity of the DOHaD hypothesis was extensively tested in a number of human populations and the mechanisms underpinning it characterised in a range of experimental animal models. Over the past decade, researchers have sought to use this mechanistic understanding of DOHaD to develop therapeutic interventions during pregnancy and early life to improve adult health. A variety of animal models have been used to develop and evaluate interventions, each with strengths and limitations. It is becoming apparent that effective translational research requires that the animal paradigm selected mirrors the tempo of human fetal growth and development as closely as possible so that the effect of a perinatal insult and/or therapeutic intervention can be fully assessed. The guinea pig is one such animal model that over the past two decades has demonstrated itself to be a very useful platform for these important reproductive studies. This review highlights similarities in the in utero development between humans and guinea pigs, the strengths and limitations of the guinea pig as an experimental model of DOHaD and the guinea pig's potential to enhance clinical therapeutic innovation to improve human health.

© 2018 The Authors. The Journal of Physiology © 2018 The Physiological Society.

Keywords: DOHaD; animal models; fetus; guinea pig; placenta; pregnancy

References

  1. Am J Physiol Regul Integr Comp Physiol. 2005 Jan;288(1):R119-26 - PubMed
  2. Endocrinology. 2008 Dec;149(12):6406-15 - PubMed
  3. Brain Res. 1999 Nov 6;846(2):236-42 - PubMed
  4. Am J Obstet Gynecol. 1985 Oct 15;153(4):462-6 - PubMed
  5. Neurochem Res. 2001 Oct;26(10):1163-9 - PubMed
  6. Am J Physiol Endocrinol Metab. 2002 Jul;283(1):E124-31 - PubMed
  7. J Neuroendocrinol. 2016 Mar;28(3):12360 - PubMed
  8. Invest Ophthalmol Vis Sci. 2008 Mar;49(3):1282-9 - PubMed
  9. J Endocrinol. 2011 Mar;208(3):301-9 - PubMed
  10. Reprod Sci. 2012 Mar;19(3):298-305 - PubMed
  11. Schizophr Res. 1999 Nov 9;40(1):11-21 - PubMed
  12. Nat Rev Endocrinol. 2014 Jul;10(7):391-402 - PubMed
  13. Reprod Fertil Dev. 1999;11(6):317-22 - PubMed
  14. Neurosci Lett. 1995 Feb 17;186(2-3):192-6 - PubMed
  15. Epigenomics. 2018 Apr 1;10(4):349-365 - PubMed
  16. Neuroendocrinology. 2001 Mar;73(3):194-202 - PubMed
  17. PLoS One. 2015 Mar 25;10(3):e0121621 - PubMed
  18. Hum Pathol. 1997 Oct;28(10):1139-45 - PubMed
  19. J Dev Orig Health Dis. 2015 Aug;6(4):350-61 - PubMed
  20. Reprod Sci. 2012 Sep;19(9):1001-9 - PubMed
  21. Ann Nutr Metab. 1987;31(4):197-210 - PubMed
  22. J Neuroendocrinol. 2010 Mar;22(3):166-74 - PubMed
  23. Am J Physiol. 1982 Sep;243(3):H404-9 - PubMed
  24. Int J Epidemiol. 2002 Dec;31(6):1235-9 - PubMed
  25. Pediatr Res. 2008 Apr;63(4):415-9 - PubMed
  26. Horm Behav. 2011 Nov;60(5):589-98 - PubMed
  27. J Pharmacol Exp Ther. 2008 Feb;324(2):576-86 - PubMed
  28. J Endocrinol. 2005 Jan;184(1):179-89 - PubMed
  29. Endocrinology. 2004 Aug;145(8):3796-803 - PubMed
  30. Early Hum Dev. 1991 Jun;25(3):157-71 - PubMed
  31. Endocrinology. 2013 Mar;154(3):1168-80 - PubMed
  32. J Infect Dis Med. 2017 Sep;2(2): - PubMed
  33. J Physiol. 2007 Jan 1;578(Pt 1):249-57 - PubMed
  34. J Am Acad Child Adolesc Psychiatry. 2010 May;49(5):453-63.e1 - PubMed
  35. Exp Neurol. 2005 Apr;192(2):265-73 - PubMed
  36. Brain Behav Evol. 2000 Jun;56(1):38-44 - PubMed
  37. J Dev Physiol. 1983 Feb;5(1):1-10 - PubMed
  38. J Endocrinol. 1966 Apr;34(4):417-23 - PubMed
  39. Semin Fetal Neonatal Med. 2004 Oct;9(5):419-25 - PubMed
  40. Am J Physiol Regul Integr Comp Physiol. 2000 Nov;279(5):R1813-20 - PubMed
  41. Behav Pharmacol. 2012 Feb;23(1):105-12 - PubMed
  42. Brain Res. 1999 Nov 6;846(2):253-9 - PubMed
  43. Card Electrophysiol Clin. 2016 Jun;8(2):257-73 - PubMed
  44. Biol Reprod. 2016 Dec;95(6):128 - PubMed
  45. Neurosci Lett. 2005 Sep 30;386(2):127-32 - PubMed
  46. Adv Exp Med Biol. 1990;277:779-90 - PubMed
  47. Anat Rec. 1946 Mar;94:359 - PubMed
  48. J Physiol. 1983 Oct;343:525-37 - PubMed
  49. Early Hum Dev. 2008 Feb;84(2):121-7 - PubMed
  50. J Physiol. 1990 Apr;423:441-51 - PubMed
  51. Placenta. 2010 Oct;31(10):902-9 - PubMed
  52. BJOG. 2003 Mar;110(3):301-5 - PubMed
  53. Placenta. 2007 Aug-Sep;28(8-9):812-5 - PubMed
  54. Pathobiol Annu. 1975;5:1-34 - PubMed
  55. Am J Reprod Immunol. 2015 Apr;73(4):341-52 - PubMed
  56. J Anat. 1992 Oct;181 ( Pt 2):373-6 - PubMed
  57. Brain Res. 1996 Sep 9;733(1):15-20 - PubMed
  58. Placenta. 2010 Mar;31 Suppl:S54-9 - PubMed
  59. Endocrinology. 2012 Jul;153(7):3269-83 - PubMed
  60. Pediatr Res. 1984 Nov;18(11):1172-5 - PubMed
  61. J Am Coll Nutr. 2004 Dec;23(6 Suppl):588S-595S - PubMed
  62. J Dairy Res. 1979 Nov;46(4):613-21 - PubMed
  63. J Physiol. 2008 Apr 15;586(8):2217-29 - PubMed
  64. Am J Hum Genet. 1962 Dec;14:353-62 - PubMed
  65. Prostaglandins. 1981 Jul;22(1):131-40 - PubMed
  66. Exp Neurol. 2011 Nov;232(1):53-65 - PubMed
  67. Respir Physiol. 1992 Sep;89(3):353-64 - PubMed
  68. J Physiol. 2016 Mar 15;594(6):1553-61 - PubMed
  69. Behav Brain Res. 2004 Apr 2;150(1-2):117-25 - PubMed
  70. Am J Obstet Gynecol. 2008 Jan;198(1):127.e1-6 - PubMed
  71. Pediatr Res. 2017 Jul;82(1):141-147 - PubMed
  72. Obstet Gynecol Surv. 1978 Feb;33(2):69-81 - PubMed
  73. Am J Physiol. 1982 Jul;243(1):H87-93 - PubMed
  74. Psychoneuroendocrinology. 2016 Aug;70:47-57 - PubMed
  75. Placenta. 2003 Aug;24(7):739-44 - PubMed
  76. Vaccine. 2011 Oct 19;29(45):8118-25 - PubMed
  77. J Dev Orig Health Dis. 2015 Jun;6(3):250-60 - PubMed
  78. Lancet. 1998 Jan 17;351(9097):173-7 - PubMed
  79. Nutr Diabetes. 2012 Dec 17;2:e57 - PubMed
  80. Pediatr Res. 1988 Nov;24(5):633-8 - PubMed
  81. J Dev Orig Health Dis. 2017 Oct;8(5):584-596 - PubMed
  82. Endocrinology. 1979 May;104(5):1393-402 - PubMed
  83. Pediatr Res. 2012 Jan;71(1):20-4 - PubMed
  84. Pediatr Res. 1986 Apr;20(4):292-5 - PubMed
  85. Neuropathol Appl Neurobiol. 1979 Mar-Apr;5(2):103-14 - PubMed
  86. Reprod Sci. 2014 Jan 9;21(7):883-891 - PubMed
  87. J Physiol. 2005 Aug 1;566(Pt 3):967-77 - PubMed
  88. Birth Defects Res B Dev Reprod Toxicol. 2003 Aug;68(4):309-20 - PubMed
  89. J Comp Neurol. 1997 Mar 3;379(1):99-112 - PubMed
  90. Am J Physiol. 1998 Mar;274(3):E410-6 - PubMed
  91. Placenta. 2009 Mar;30(3):236-40 - PubMed
  92. J Neurosci. 2001 Feb 15;21(4):1302-12 - PubMed
  93. Vaccine. 2009 Dec 10;28(1):63-70 - PubMed
  94. Neuroscience. 2004;129(2):381-91 - PubMed
  95. J Physiol. 2016 Mar 15;594(6):1753-72 - PubMed
  96. Neurochem Res. 2016 Jul;41(7):1831-43 - PubMed
  97. Placenta. 2013 Jan;34(1):20-8 - PubMed
  98. Dev Neurosci. 2015;37(6):533-45 - PubMed
  99. Am J Obstet Gynecol. 1992 Jan;166(1 Pt 1):213-8 - PubMed
  100. J Pharm Pharmacol. 2009 Aug;61(8):1111-8 - PubMed
  101. Placenta. 2015 Jun;36(6):623-30 - PubMed
  102. J Exp Zool A Ecol Genet Physiol. 2012 Jan 1;317(1):24-31 - PubMed
  103. Reprod Fertil Dev. 1995;7(5):1285-92 - PubMed
  104. Behav Brain Res. 2012 Jul 15;233(1):162-8 - PubMed
  105. Am J Obstet Gynecol. 2008 Jul;199(1):78.e1-6 - PubMed
  106. JAMA. 2002 Aug 14;288(6):728-37 - PubMed
  107. J Neurosci. 2001 Dec 15;21(24):9770-81 - PubMed
  108. Exp Physiol. 2002 Jul;87(4):469-77 - PubMed
  109. J Neuroendocrinol. 2005 Sep;17(9):600-8 - PubMed
  110. Endocrinology. 2012 Jul;153(7):3295-307 - PubMed
  111. Neurochem Res. 1992 Dec;17(12):1211-6 - PubMed
  112. Front Zool. 2015 Aug 24;12 Suppl 1:S13 - PubMed
  113. J Intern Med. 2007 Dec;262(6):635-42 - PubMed
  114. Biol Reprod. 2003 Jul;69(1):1-7 - PubMed
  115. Am J Physiol Regul Integr Comp Physiol. 2011 Dec;301(6):R1731-7 - PubMed
  116. PLoS One. 2016 Feb 03;11(2):e0148226 - PubMed
  117. Behav Brain Res. 2009 Jan 30;197(1):144-9 - PubMed
  118. Expert Rev Cardiovasc Ther. 2017 Mar;15(3):211-220 - PubMed
  119. J Auton Nerv Syst. 1983 Feb;7(2):111-8 - PubMed
  120. Neurochem Res. 1988 Nov;13(11):1055-60 - PubMed
  121. J Nutr Biochem. 2002 Dec;13(12):747-753 - PubMed
  122. Reprod Sci. 2010 Jun;17(6):540-8 - PubMed
  123. J Clin Endocrinol Metab. 1999 Aug;84(8):2820-5 - PubMed
  124. Int J Dev Neurosci. 2017 May;58:50-58 - PubMed
  125. Acta Physiol Scand. 1992 Jun;145(2):195-6 - PubMed
  126. J Dev Physiol. 1984 Dec;6(6):441-59 - PubMed
  127. Brain Res Dev Brain Res. 1989 Jan 1;45(1):129-35 - PubMed
  128. J Neuroendocrinol. 2006 Nov;18(11):826-34 - PubMed
  129. Eur Child Adolesc Psychiatry. 2006 Dec;15 Suppl 1:I15-24 - PubMed
  130. J Neuropathol Exp Neurol. 2001 May;60(5):470-82 - PubMed
  131. J Neuroendocrinol. 2001 May;13(5):425-31 - PubMed
  132. Pediatr Res. 2016 Aug;80(2):275-83 - PubMed
  133. Dev Psychobiol. 2007 Nov;49(7):664-74 - PubMed
  134. Br J Prev Soc Med. 1977 Jun;31(2):91-5 - PubMed
  135. Comp Med. 2000 Aug;50(4):379-84 - PubMed
  136. J Dev Physiol. 1983 Oct;5(5):323-32 - PubMed
  137. J Dev Orig Health Dis. 2016 Oct;7(5):449-472 - PubMed
  138. Acta Physiol Scand. 1993 Nov;149(3):331-7 - PubMed
  139. Neuroendocrinology. 2001 May;73(5):302-11 - PubMed
  140. Growth Factors. 2016 Feb;34(1-2):33-41 - PubMed
  141. Gen Pharmacol. 1994 Jan;25(1):15-8 - PubMed
  142. Placenta. 2000 May;21(4):313-9 - PubMed
  143. Nutr Metab (Lond). 2006 Mar 27;3:17 - PubMed
  144. Neurochem Res. 1999 Mar;24(3):437-46 - PubMed
  145. Physiol Behav. 2013 Aug 15;120:143-9 - PubMed
  146. Gen Comp Endocrinol. 1992 May;86(2):275-83 - PubMed
  147. Neurotox Res. 2016 May;29(4):594-604 - PubMed
  148. Reprod Sci. 2016 Aug;23(8):1087-95 - PubMed
  149. Am J Physiol. 1977 Dec;233(6):H707-10 - PubMed
  150. Gen Comp Endocrinol. 2012 Mar 1;176(1):18-27 - PubMed
  151. Dev Med Child Neurol. 2015 May;57(5):420-30 - PubMed
  152. Reprod Sci. 2013 Nov;20(11):1365-75 - PubMed
  153. Pediatr Res. 1987 May;21(5):427-31 - PubMed
  154. J Theor Biol. 2016 Nov 7;408:1-12 - PubMed
  155. Handb Clin Neurol. 2013;113:1299-310 - PubMed
  156. Reprod Toxicol. 2012 Jun;33(3):374-81 - PubMed
  157. Pediatr Res. 2002 Jun;51(6):675-80 - PubMed
  158. Placenta. 2007 Nov-Dec;28(11-12):1234-8 - PubMed
  159. Pediatr Res. 2003 Oct;54(4):523-8 - PubMed
  160. Am J Clin Nutr. 2011 Dec;94(6 Suppl):1838S-1845S - PubMed
  161. Cereb Cortex. 2016 Dec;26(12):4574-4589 - PubMed
  162. Am J Obstet Gynecol. 2011 Mar;204(3):254.e16-28 - PubMed
  163. Am J Physiol. 1990 Dec;259(6 Pt 1):L359-64 - PubMed
  164. Pediatr Res. 1990 Sep;28(3):203-8 - PubMed
  165. Neurosci Lett. 1995 Feb 13;185(3):159-62 - PubMed
  166. Biol Neonate. 1986;49(3):172-80 - PubMed
  167. Dev Dyn. 1992 Jul;194(3):177-92 - PubMed
  168. Can J Physiol Pharmacol. 2009 Nov;87(11):973-8 - PubMed
  169. Reprod Sci. 2016 Feb;23(2):219-27 - PubMed
  170. Placenta. 2007 Apr;28 Suppl A:S41-7 - PubMed
  171. Am J Physiol Regul Integr Comp Physiol. 2018 May 1;314(5):R647-R654 - PubMed
  172. Sci Rep. 2017 Sep 18;7(1):11814 - PubMed
  173. Am J Physiol. 1995 Jan;268(1 Pt 2):R72-7 - PubMed
  174. Biol Reprod. 1998 Dec;59(6):1378-84 - PubMed
  175. J Neurochem. 1999 Nov;73(5):2139-48 - PubMed
  176. Neuroscience. 2005;130(4):949-55 - PubMed
  177. J Dev Orig Health Dis. 2014 Apr;5(2):74-8 - PubMed
  178. J Dev Physiol. 1983 Feb;5(1):11-21 - PubMed
  179. Placenta. 2001 Apr;22 Suppl A:S77-82 - PubMed
  180. Muscle Nerve. 1991 Mar;14(3):259-67 - PubMed
  181. Prog Cardiovasc Dis. 1972 Jul-Aug;15(1):87-111 - PubMed
  182. Epigenetics. 2013 Sep;8(9):944-52 - PubMed
  183. Pediatr Res. 2009 Feb;65(2):188-92 - PubMed
  184. Am J Physiol Regul Integr Comp Physiol. 2017 Oct 1;313(4):R330-R339 - PubMed
  185. Neuroscience. 2000;100(2):327-33 - PubMed
  186. Int J Dev Neurosci. 2018 Apr;65:1-10 - PubMed
  187. Placenta. 2009 Feb;30(2):136-41 - PubMed
  188. J Dev Physiol. 1984 Dec;6(6):461-72 - PubMed
  189. Brain Res. 2001 Mar 30;896(1-2):179-82 - PubMed
  190. BMJ. 1990 Aug 4;301(6746):259-62 - PubMed
  191. Fertil Steril. 2007 Sep;88(3):675-83 - PubMed
  192. J Reprod Fertil. 1971 May;25(2):305-6 - PubMed
  193. Placenta. 1992 Jan-Feb;13(1):1-15 - PubMed
  194. J Dev Orig Health Dis. 2017 Aug;8(4):448-464 - PubMed
  195. Brain Res. 1999 Jan 30;817(1-2):117-22 - PubMed
  196. Horm Res. 2005;64 Suppl 3:2-7 - PubMed
  197. J Physiol. 2014 Dec 15;592(24):5429-43 - PubMed
  198. Brain Res Dev Brain Res. 2005 Apr 21;156(1):32-7 - PubMed
  199. Am J Physiol Endocrinol Metab. 2001 May;280(5):E729-39 - PubMed
  200. J Physiol. 2011 Feb 1;589(Pt 3):755-66 - PubMed
  201. Physiol Rev. 1985 Apr;65(2):357-430 - PubMed
  202. Neurotox Res. 2013 Jul;24(1):80-93 - PubMed
  203. Pediatr Res. 1998 Jan;43(1):126-31 - PubMed
  204. Dev Neurosci. 2015;37(4-5):453-63 - PubMed
  205. J Appl Physiol Respir Environ Exerc Physiol. 1983 Sep;55(3):834-41 - PubMed
  206. J Physiol. 2008 Sep 1;586(17):4317-26 - PubMed
  207. Reprod Sci. 2011 Nov;18(11):1103-10 - PubMed
  208. J Dev Orig Health Dis. 2016 Oct;7(5):548-562 - PubMed
  209. Int J Biochem. 1991;23(4):467-71 - PubMed
  210. Dis Model Mech. 2017 Feb 1;10(2):151-162 - PubMed
  211. Neurochem Res. 1995 Oct;20(10):1171-7 - PubMed
  212. Muscle Nerve. 1979 Jul-Aug;2(4):250-6 - PubMed
  213. Mol Cell Biochem. 1994 Apr-May;133-134:277-86 - PubMed
  214. Alcohol. 2014 Aug;48(5):477-81 - PubMed
  215. J Physiol. 2007 Jun 15;581(Pt 3):1033-42 - PubMed
  216. Am J Obstet Gynecol. 2004 Sep;191(3):847-55 - PubMed
  217. Physiol Rep. 2014 Sep 17;2(9): - PubMed
  218. Acta Physiol Scand. 1970 Oct;80(2):276-88 - PubMed
  219. Am J Physiol Endocrinol Metab. 2007 Mar;292(3):E668-76 - PubMed
  220. Ann Anat. 2015 Jul;200:66-72 - PubMed
  221. Reprod Toxicol. 2011 May;31(4):500-6 - PubMed
  222. Am J Physiol Regul Integr Comp Physiol. 2009 Sep;297(3):R525-45 - PubMed
  223. Eur J Appl Physiol Occup Physiol. 1975 Aug 15;34(3):149-56 - PubMed
  224. Aust J Exp Biol Med Sci. 1975 Jun;53(3):215-22 - PubMed
  225. Comp Med. 2012 Apr;62(2):109-15 - PubMed
  226. Arch Biochem Biophys. 1976 Jun;174(2):506-22 - PubMed
  227. PLoS One. 2014 Jun 13;9(6):e98433 - PubMed
  228. Br J Nutr. 1994 Aug;72(2):173-80 - PubMed
  229. J Dev Physiol. 1987 Apr;9(2):181-201 - PubMed
  230. Psychopharmacology (Berl). 1993;110(4):490-6 - PubMed
  231. Am J Physiol Endocrinol Metab. 2015 Feb 15;308(4):E306-14 - PubMed
  232. Pediatr Res. 2012 Jan;71(1):25-31 - PubMed
  233. Eur J Hum Genet. 2006 Feb;14(2):159-66 - PubMed
  234. Psychopharmacology (Berl). 2007 Nov;195(1):95-102 - PubMed
  235. Clin Exp Pharmacol Physiol. 2008 Jul;35(7):730-43 - PubMed
  236. Endocrinology. 2003 Jul;144(7):2775-84 - PubMed
  237. J Comp Physiol B. 2011 Dec;181(8):1089-100 - PubMed
  238. J Soc Gynecol Investig. 2005 Sep;12(6):388-95 - PubMed
  239. Neurosci Lett. 2008 Jul 4;439(1):94-9 - PubMed
  240. Am J Obstet Gynecol. 1985 Oct 15;153(4):467-71 - PubMed
  241. Adv Anat Embryol Cell Biol. 2015;216:5-25 - PubMed
  242. J Dev Physiol. 1991 Mar;15(3):153-60 - PubMed
  243. Hum Reprod Update. 2016 Mar-Apr;22(2):164-81 - PubMed
  244. Pediatr Res. 2005 Oct;58(4):677-84 - PubMed
  245. Br J Nutr. 2007 Mar;97(3):435-9 - PubMed
  246. Front Physiol. 2017 Mar 10;8:144 - PubMed
  247. Placenta. 2002 Nov;23(10):763-70 - PubMed
  248. J Endocrinol. 2003 Dec;179(3):437-45 - PubMed
  249. Nat Rev Endocrinol. 2014 Jul;10(7):403-11 - PubMed
  250. J Neurodev Disord. 2013 Jul 03;5(1):17 - PubMed
  251. Dev Neurosci. 2013;35(5):416-26 - PubMed
  252. Nature. 2008 Jun 5;453(7196):783-7 - PubMed
  253. Int J Dev Neurosci. 1990;8(3):233-44 - PubMed
  254. Exp Lung Res. 2011 Feb;37(1):44-56 - PubMed
  255. Front Zool. 2014 Apr 09;11(1):30 - PubMed
  256. PLoS One. 2011;6(8):e23360 - PubMed
  257. J Physiol. 2017 Feb 15;595(4):1077-1092 - PubMed
  258. Brain Res Dev Brain Res. 2004 Mar 22;149(1):39-44 - PubMed
  259. Pediatr Res. 2005 Nov;58(5):845-9 - PubMed
  260. J Physiol. 2016 Jan 15;594(2):437-52 - PubMed
  261. Pediatr Res. 1986 Aug;20(8):730-4 - PubMed
  262. Nutr Metab. 1980;24(6):357-66 - PubMed
  263. Theriogenology. 2014 Apr 15;81(7):896-900 - PubMed
  264. Ann Nutr Metab. 1981;25(3):165-77 - PubMed
  265. Sleep. 1985 Dec;8(4):347-55 - PubMed
  266. PLoS One. 2014 Mar 26;9(3):e92167 - PubMed
  267. Nature. 1999 Jan 21;397(6716):251-5 - PubMed
  268. Clin Sci (Lond). 1991 Sep;81(3):439-46 - PubMed
  269. Experientia. 1988 Jan 15;44(1):1-9 - PubMed
  270. Endocrinology. 2013 Nov;154(11):4170-81 - PubMed
  271. Biol Neonate. 1992;62(2-3):89-95 - PubMed
  272. J Physiol. 2010 Mar 1;588(Pt 5):887-99 - PubMed
  273. J Soc Gynecol Investig. 2006 Oct;13(7):483-90 - PubMed
  274. Brain Res. 1988 Aug 1;470(2):173-9 - PubMed
  275. Placenta. 2006 Apr;27 Suppl A:S30-3 - PubMed
  276. Am J Physiol Regul Integr Comp Physiol. 2003 Jan;284(1):R140-52 - PubMed
  277. J Endocrinol. 1955 Mar;12(2):115-9 - PubMed
  278. Pediatr Res. 2010 Jul;68(1):84-8 - PubMed
  279. Placenta. 2004 May;25(5):438-48 - PubMed
  280. Front Neuroendocrinol. 2017 Oct;47:154-166 - PubMed
  281. Circ Res. 1985 Mar;56(3):377-91 - PubMed
  282. Dev Neuropsychol. 2009;34(4):393-421 - PubMed
  283. Birth Defects Res. 2017 Mar 15;109(5):324-335 - PubMed
  284. Neurotoxicol Teratol. 2010 Mar-Apr;32(2):164-70 - PubMed
  285. J Endocrinol. 1971 Oct;51(2):333-45 - PubMed
  286. ILAR J. 2006;47(1):5-14 - PubMed
  287. Arch Dis Child. 2006 Aug;91(8):655-60 - PubMed
  288. Ultrasound Obstet Gynecol. 2017 Jan;49(1):54-60 - PubMed
  289. Placenta. 2013 Apr;34(4):325-30 - PubMed
  290. J Neurobiol. 2003 Apr;55(1):41-52 - PubMed
  291. Physiol Behav. 2016 Oct 1;164(Pt A):233-48 - PubMed
  292. Placenta. 2001 Feb-Mar;22(2-3):177-85 - PubMed
  293. Am J Physiol. 1999 Dec;277(6):R1675-82 - PubMed
  294. Am J Physiol. 1989 Jan;256(1 Pt 2):F13-7 - PubMed
  295. Neurosci Lett. 1993 Apr 16;153(1):93-7 - PubMed
  296. J Dev Orig Health Dis. 2016 Jun;7(3):237-243 - PubMed
  297. Int J Obes (Lond). 2006 Dec;30 Suppl 4:S50-7 - PubMed
  298. Brain Res. 1970 Jan 6;17(1):115-23 - PubMed
  299. Lipids Health Dis. 2006 Aug 15;5:22 - PubMed
  300. J Appl Physiol (1985). 2008 Jul;105(1):316-21 - PubMed
  301. Horm Behav. 2008 Sep;54(4):514-20 - PubMed
  302. J Psychiatr Res. 2011 Aug;45(8):1027-35 - PubMed
  303. J Dev Orig Health Dis. 2015 Apr;6(2):143-8 - PubMed
  304. Neurochem Res. 1988 Aug;13(8):765-70 - PubMed
  305. J Physiol. 2005 Jul 15;566(Pt 2):467-80 - PubMed
  306. Reprod Sci. 2013 Mar;20(3):299-307 - PubMed
  307. Brain Res. 2001 Jan 26;890(1):130-6 - PubMed
  308. Am J Obstet Gynecol. 2002 Apr;186(4):658-62 - PubMed
  309. Stress. 2017 Nov;20(6):580-588 - PubMed
  310. Am J Physiol Regul Integr Comp Physiol. 2017 Jul 1;313(1):R19-R28 - PubMed
  311. Acta Obstet Gynecol Scand. 2013 Jul;92(7):862-5 - PubMed
  312. J Physiol. 2004 Jul 1;558(Pt 1):305-18 - PubMed
  313. Cardiovasc Drugs Ther. 2008 Apr;22(2):107-14 - PubMed
  314. Int J Endocrinol. 2014;2014:916918 - PubMed
  315. Am J Physiol Endocrinol Metab. 2015 May 1;308(9):E805-21 - PubMed
  316. Lab Anim. 2017 Apr;51(2):181-190 - PubMed
  317. Neurosci Lett. 2008 Aug 8;440(3):227-31 - PubMed
  318. J Biol Chem. 1985 Sep 15;260(20):10926-9 - PubMed
  319. Pediatr Res. 1972 Oct;6(10):765-72 - PubMed
  320. J Pharmacol Toxicol Methods. 2008 Jan-Feb;57(1):23-9 - PubMed
  321. Alcohol. 1997 Mar-Apr;14(2):117-24 - PubMed
  322. Semin Fetal Neonatal Med. 2010 Aug;15(4):191-5 - PubMed
  323. Brain Res. 1998 Jul 6;798(1-2):166-72 - PubMed
  324. J Magn Reson Imaging. 2015 Sep;42(3):658-65 - PubMed
  325. Hum Gene Ther. 2016 Dec;27(12):997-1007 - PubMed
  326. J Neuroendocrinol. 2007 Mar;19(3):172-80 - PubMed

MeSH terms

Publication Types

Grant support