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Castle KD, Chen M, Wisdom AJ, et al. Genetically engineered mouse models for studying radiation biology. Transl Cancer Res. 2017;6:S900-S913doi: 10.21037/tcr.2017.06.19.
Castle, K. D., Chen, M., Wisdom, A. J., & Kirsch, D. G. (2017). Genetically engineered mouse models for studying radiation biology. Translational cancer research, 6S900-S913. https://doi.org/10.21037/tcr.2017.06.19
Castle, Katherine D, et al. "Genetically engineered mouse models for studying radiation biology." Translational cancer research vol. 6 (2017): S900-S913. doi: https://doi.org/10.21037/tcr.2017.06.19
Castle KD, Chen M, Wisdom AJ, Kirsch DG. Genetically engineered mouse models for studying radiation biology. Transl Cancer Res. 2017 Jul;6:S900-S913. doi: 10.21037/tcr.2017.06.19. PMID: 30733931; PMCID: PMC6363345.
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Transl Cancer Res. 2017 Jul;6:S900-S913. doi: 10.21037/tcr.2017.06.19.

Genetically engineered mouse models for studying radiation biology.

Translational cancer research

Katherine D Castle, Mark Chen, Amy J Wisdom, David G Kirsch

Affiliations

  1. Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina, USA.
  2. Medical Scientist Training Program, Duke University Medical Center, Durham, North Carolina, USA.
  3. Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina, USA.

PMID: 30733931 PMCID: PMC6363345 DOI: 10.21037/tcr.2017.06.19

Abstract

Genetically engineered mouse models (GEMMs) are valuable research tools that have transformed our understanding of cancer. The first GEMMs generated in the 1980s and 1990s were knock-in and knock-out models of single oncogenes or tumor suppressors. The advances that made these models possible catalyzed both technological and conceptual shifts in the way cancer research was conducted. As a result, dozens of mouse models of cancer exist today, covering nearly every tissue type. The advantages inherent to GEMMs compared to

Keywords: CRISPR; Cre-loxP; RCAS-TVA; genetically engineered mouse models (GEMMs); radiation biology

Conflict of interest statement

Conflicts of Interest: DG Kirsch is a member of the scientific advisory board and owns stock in Lumicell Diagnostics, a company commercializing intraoperative imaging systems. DG Kirsch is a founder a

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