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Lin YC, Chen HC, Chen HK, et al. Ultrastructural Changes Associated With the Enhanced Permeability of the Round Window Membrane Mediated by Ultrasound Microbubbles. Front Pharmacol. 2020;10:1580doi: 10.3389/fphar.2019.01580.
Lin, Y. C., Chen, H. C., Chen, H. K., Lin, Y. Y., Kuo, C. Y., Wang, H., Hung, C. L., Shih, C. P., & Wang, C. H. (2019). Ultrastructural Changes Associated With the Enhanced Permeability of the Round Window Membrane Mediated by Ultrasound Microbubbles. Frontiers in pharmacology, 101580. https://doi.org/10.3389/fphar.2019.01580
Lin, Yi-Chun, et al. "Ultrastructural Changes Associated With the Enhanced Permeability of the Round Window Membrane Mediated by Ultrasound Microbubbles." Frontiers in pharmacology vol. 10 (2019): 1580. doi: https://doi.org/10.3389/fphar.2019.01580
Lin YC, Chen HC, Chen HK, Lin YY, Kuo CY, Wang H, Hung CL, Shih CP, Wang CH. Ultrastructural Changes Associated With the Enhanced Permeability of the Round Window Membrane Mediated by Ultrasound Microbubbles. Front Pharmacol. 2020 Jan 28;10:1580. doi: 10.3389/fphar.2019.01580. eCollection 2019. PMID: 32047431; PMCID: PMC6997169.
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Front Pharmacol. 2020 Jan 28;10:1580. doi: 10.3389/fphar.2019.01580. eCollection 2019.

Ultrastructural Changes Associated With the Enhanced Permeability of the Round Window Membrane Mediated by Ultrasound Microbubbles.

Frontiers in pharmacology

Yi-Chun Lin, Hsin-Chien Chen, Hang-Kang Chen, Yuan-Yung Lin, Chao-Yin Kuo, Hao Wang, Chia-Lien Hung, Cheng-Ping Shih, Chih-Hung Wang

Affiliations

  1. Graduate Institute of Medical Sciences, National Defense Medical Center, Taipei, Taiwan.
  2. Department of Otolaryngology-Head and Neck Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
  3. Teaching and Research Section, Taichung Armed Forces General Hospital, Taichung, Taiwan.
  4. Taichung Armed Forces General Hospital, Taichung, Taiwan.

PMID: 32047431 PMCID: PMC6997169 DOI: 10.3389/fphar.2019.01580

Abstract

The round window membrane (RWM) is the most common entryway for local drug and gene delivery into the inner ear, but its permeability can change the treatment outcome. We previously demonstrated a feasible and highly efficient approach using ultrasound-aided microbubble (USMB) cavitation to enhance the permeability of the RWM. Here, we investigated the safety of USMB exposure and the association between temporal changes in RWM permeability and ultrastructure. Experimental guinea pigs were divided into two treatment groups: a control group receiving round window soaking (RWS) with MBs and treatment (USM) groups undergoing 3 (USM-3) or 5 (USM-5) consecutive USMB exposures (1 min/exposure) at an acoustic intensity of 3 W/cm

Copyright © 2020 Lin, Chen, Chen, Lin, Kuo, Wang, Hung, Shih and Wang.

Keywords: inner ear; microbubble; permeability; round window membrane (RWM); scanning electron microscope (SEM); transmission electron microscope (TEM); ultrasound; ultrastructure

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