Display options
Cite
Nguyen CM, Stauber J, Baliss M, et al. Life-Threatening Intraventricular Rupture of Brain Abscess in a Patient With Undiagnosed Hereditary Hemorrhagic Telangiectasia. Cureus. 2020;12(6):e8732doi: 10.7759/cureus.8732.
Nguyen, C. M., Stauber, J., Baliss, M., & Reynoso, D. (2020). Life-Threatening Intraventricular Rupture of Brain Abscess in a Patient With Undiagnosed Hereditary Hemorrhagic Telangiectasia. Cureus, 12(6), e8732. https://doi.org/10.7759/cureus.8732
Nguyen, Christopher M, et al. "Life-Threatening Intraventricular Rupture of Brain Abscess in a Patient With Undiagnosed Hereditary Hemorrhagic Telangiectasia." Cureus vol. 12,6 (2020): e8732. doi: https://doi.org/10.7759/cureus.8732
Nguyen CM, Stauber J, Baliss M, Reynoso D. Life-Threatening Intraventricular Rupture of Brain Abscess in a Patient With Undiagnosed Hereditary Hemorrhagic Telangiectasia. Cureus. 2020 Jun 21;12(6):e8732. doi: 10.7759/cureus.8732. PMID: 32714672; PMCID: PMC7377030.
Copy Download .nbib Format: NLM
Share it on

Cureus. 2020 Jun 21;12(6):e8732. doi: 10.7759/cureus.8732.

Life-Threatening Intraventricular Rupture of Brain Abscess in a Patient With Undiagnosed Hereditary Hemorrhagic Telangiectasia.

Cureus

Christopher M Nguyen, Jessica Stauber, Michelle Baliss, David Reynoso

Affiliations

  1. Internal Medicine, University of Texas Medical Branch at Galveston, Galveston, USA.
  2. Medicine, University of Texas Medical Branch at Galveston, Galveston, USA.
  3. Infectious Disease, University of Texas Medical Branch at Galveston, Galveston, USA.

PMID: 32714672 PMCID: PMC7377030 DOI: 10.7759/cureus.8732

Abstract

Hereditary hemorrhagic telangiectasia (HHT) is an autosomal dominant genetic condition associated with mucocutaneous and visceral arteriovenous malformations (AVMs), including pulmonary AVMs, which predispose patients to systemic paradoxical emboli that can lead to brain abscesses. Intraventricular rupture of brain abscess (IVROBA) is a feared complication with a high mortality rate. Here, we present a case with brain abscesses complicated by IVROBA and ventriculitis as the initial presentation of HHT in an undiagnosed patient. We also discuss the diagnostic and therapeutic approach that resulted in this patient's clinical improvement.

Copyright © 2020, Nguyen et al.

Keywords: arteriovenous malformation; brain abscess; hereditary hemorrhagic telangiectasia; intraventricular rupture of brain abscess; osler-weber-rendu; pulmonary arteriovenous malformation; septic emboli; ventriculitis

Conflict of interest statement

The authors have declared that no competing interests exist.

References

  1. Neurosurgery. 2001 Feb;48(2):310-6; discussion 316-7 - PubMed
  2. Cardiovasc Diagn Ther. 2018 Jun;8(3):325-337 - PubMed
  3. QJM. 2002 Aug;95(8):501-9 - PubMed
  4. J Clin Neurosci. 2020 Jan;71:191-198 - PubMed
  5. Otolaryngol Clin North Am. 2018 Feb;51(1):237-254 - PubMed
  6. Eur J Clin Microbiol Infect Dis. 2017 Oct;36(10):1975-1980 - PubMed
  7. Neurology. 2000 Oct 10;55(7):959-64 - PubMed
  8. Surg Neurol. 2006 Jun;65(6):557-62; discussion 562 - PubMed
  9. Nat Rev Immunol. 2017 Jan;17(1):7-20 - PubMed
  10. Clin Neurol Neurosurg. 2012 Apr;114(3):235-40 - PubMed
  11. Eur Radiol. 2018 Mar;28(3):1338-1344 - PubMed
  12. Am J Med Genet. 2000 Mar 6;91(1):66-7 - PubMed
  13. Am J Respir Crit Care Med. 1998 Aug;158(2):643-61 - PubMed
  14. Haematologica. 2019 Feb;104(2):e85-e86 - PubMed

Publication Types