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Exp Ther Med. 2021 May;21(5):520. doi: 10.3892/etm.2021.9951. Epub 2021 Mar 22.

Predictive role of altered leptin, adiponectin and 3-carboxy-4-methyl-5-propyl-2-furanpropanoic acid secretion in gestational diabetes mellitus.

Experimental and therapeutic medicine

Andreea Roxana Florian, Gheorghe Cruciat, Raluca Maria Pop, Adelina Staicu, Muresan Daniel, Stamatian Florin


  1. Obstetrics and Gynecology I, Mother and Child Department, 'Iuliu Ha?ieganu' University of Medicine and Pharmacy, 400006 Cluj-Napoca, Romania.
  2. Department of Pharmacology, Toxicology and Clinical Pharmacology, 'Iuliu Ha?ieganu' University of Medicine and Pharmacy, 400337 Cluj-Napoca, Romania.

PMID: 33815593 PMCID: PMC8014980 DOI: 10.3892/etm.2021.9951


Gestational diabetes mellitus (GDM) is one of the most common complications of pregnancy, leading to considerable maternal and fetal risks. The main aim of this study was to determine the predictive value of the levels of adiponectin (AN), leptin (L) and CMPF (3-carboxy-4-methyl-5-propyl-2-furanpropanoic acid) in the development of GDM. We conducted a prospective longitudinal study on 68 pregnant women that were not at risk of developing GDM, in whom we determined AN, L, CMPF levels at 11-13 weeks +6 days of pregnancy during the first trimester screening. Twenty-one of all the patients included in the study developed GDM during pregnancy. Oral glucose tolerance test (OGTT)/75 g was performed at 24-28 weeks of gestation. L levels were significantly higher in patients who developed GDM than in those who did not develop diabetes (P<0.001). The AN/L ratio was significantly lower in patients with GDM (P=0.03). AN and CMPF levels were not associated with GDM. The probability of developing gestational diabetes was higher in patients with L levels above the L cut-off value of 16 ng/ml [area under the curve (AUC), 0.775; 95% confidence interval (CI) 0.658-0.867], sensitivity 100% (95% CI 83.9-100), specificity 48.9% (95% CI 34.1-63.9) (P<0.001). Advanced maternal age and higher L levels were found to be predictive factors [odds ratio (OR)=1.16 and OR=1.06, respectively] independently associated with gestational diabetes. In as far as general factors are concerned, the patient BMI (body mass index) at the beginning of the pregnancy and smoking were found to be the main risk factors for the onset of GDM. This study showed that elevated L levels are a strong predictor of GDM, while AN and CMPF levels are not, as they failed to show a significant association.

Copyright: © Florian et al.

Keywords: CMPF; adipokines; adiponectin; adiponectin/leptin ratio; gestational diabetes mellitus; leptin

Conflict of interest statement

The authors declare that they have no competing interests.


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