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Künzel SR, Hoffmann M, Weber S, et al. Diminished PLK2 Induces Cardiac Fibrosis and Promotes Atrial Fibrillation. Circ Res. 2021;129(8):804-820doi: 10.1161/CIRCRESAHA.121.319425.
Künzel, S. R., Hoffmann, M., Weber, S., Künzel, K., Kämmerer, S., Günscht, M., Klapproth, E., Rausch, J. S. E., Sadek, M. S., Kolanowski, T., Meyer-Roxlau, S., Piorkowski, C., Tugtekin, S. M., Rose-John, S., Yin, X., Mayr, M., Kuhlmann, J. D., Wimberger, P., Grützmann, K., Herzog, N., Küpper, J. H., O'Reilly, M., Kabir, S. N., Sommerfeld, L. C., Guan, K., Wielockx, B., Fabritz, L., Nattel, S., Ravens, U., Dobrev, D., Wagner, M., & El-Armouche, A. (2021). Diminished PLK2 Induces Cardiac Fibrosis and Promotes Atrial Fibrillation. Circulation research, 129(8), 804-820. https://doi.org/10.1161/CIRCRESAHA.121.319425
Künzel, Stephan R, et al. "Diminished PLK2 Induces Cardiac Fibrosis and Promotes Atrial Fibrillation." Circulation research vol. 129,8 (2021): 804-820. doi: https://doi.org/10.1161/CIRCRESAHA.121.319425
Künzel SR, Hoffmann M, Weber S, Künzel K, Kämmerer S, Günscht M, Klapproth E, Rausch JSE, Sadek MS, Kolanowski T, Meyer-Roxlau S, Piorkowski C, Tugtekin SM, Rose-John S, Yin X, Mayr M, Kuhlmann JD, Wimberger P, Grützmann K, Herzog N, Küpper JH, O'Reilly M, Kabir SN, Sommerfeld LC, Guan K, Wielockx B, Fabritz L, Nattel S, Ravens U, Dobrev D, Wagner M, El-Armouche A. Diminished PLK2 Induces Cardiac Fibrosis and Promotes Atrial Fibrillation. Circ Res. 2021 Oct;129(8):804-820. doi: 10.1161/CIRCRESAHA.121.319425. Epub 2021 Aug 26. PMID: 34433292; PMCID: PMC8487716.
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Circ Res. 2021 Oct;129(8):804-820. doi: 10.1161/CIRCRESAHA.121.319425. Epub 2021 Aug 26.

Diminished PLK2 Induces Cardiac Fibrosis and Promotes Atrial Fibrillation.

Circulation research

Stephan R Künzel, Maximilian Hoffmann, Silvio Weber, Karolina Künzel, Susanne Kämmerer, Mario Günscht, Erik Klapproth, Johanna S E Rausch, Mirna S Sadek, Tomasz Kolanowski, Stefanie Meyer-Roxlau, Christopher Piorkowski, Sems M Tugtekin, Stefan Rose-John, Xiaoke Yin, Manuel Mayr, Jan Dominik Kuhlmann, Pauline Wimberger, Konrad Grützmann, Natalie Herzog, Jan-Heiner Küpper, Molly O'Reilly, S Nashitha Kabir, Laura C Sommerfeld, Kaomei Guan, Ben Wielockx, Larissa Fabritz, Stanley Nattel, Ursula Ravens, Dobromir Dobrev, Michael Wagner, Ali El-Armouche

Affiliations

  1. Institute of Pharmacology and Toxicology, Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden (S.R.K., M.H., S.W., K.K., S.K., M.G., E.K., J.S.E.R., M.S.S., T.K., S.M.-R., K.G., M.W., A.E.-A.).
  2. Department of Dermatology, Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden (S.R.K.).
  3. Department of Rhythmology (C.P., M.W.), Clinic for Internal Medicine and Cardiology, Heart Center Dresden GmbH, Dresden, Technische Universität Dresden.
  4. Department of Cardiac Surgery (S.M.T.), Clinic for Internal Medicine and Cardiology, Heart Center Dresden GmbH, Dresden, Technische Universität Dresden.
  5. Unit for Degradomics of the Protease Web, Institute of Biochemistry, University of Kiel (S.R.-J.).
  6. The James Black Centre, King's College, University of London (X.Y., M.M.).
  7. Internal Medicine III, University Hospital Carl Gustav Carus, Technische Universität Dresden (M.M.).
  8. Department of Gynecology and Obstetrics, Medical Faculty and University Hospital Carl Gustav Carus, Technische Universität Dresden (J.D.K., P.W.).
  9. German Cancer Consortium (DKTK), Dresden and German Cancer Research Center (DKFZ), Heidelberg (J.D.K., P.W.).
  10. National Center for Tumor Diseases (NCT), Partner Site Dresden (J.D.K., P.W., K.G.).
  11. Brandenburg University of Technology, Senftenberg (N.H., J.-H.K.).
  12. Institute of Cardiovascular Sciences, University of Birmingham (M.O., S.N.K., L.C.S.).
  13. University Center of Cardiovascular Science and Department of Cardiology, University Heart and Vascular Center Hamburg (L.F., L.C.S.).
  14. Institute of Clinical Chemistry and Laboratory Medicine, Technische Universität Dresden (B.W.).
  15. Department of Cardiology, University Hospitals Birmingham (L.F.).
  16. Department of Medicine, Montreal Heart Institute and Université de Montréal, Quebec, Canada (S.N., D.D.).
  17. Institute of Pharmacology, West German Heart and Vascular Center, University Duisburg-Essen (S.N., D.D.).
  18. IHU Liryc, Electrophysiology and Heart Modeling Institute, Fondation Bordeaux Université (S.N.).
  19. Institut für Experimentelle Kardiovaskuläre Medizin, Universitäts Herzzentrum, Freiburg Bad Krotzingen, Freiburg im Breisgau (U.R.).
  20. Department of Molecular Physiology and Biophysics, Baylor College of Medicine (D.D.).

PMID: 34433292 PMCID: PMC8487716 DOI: 10.1161/CIRCRESAHA.121.319425

Abstract

[Figure: see text].

Keywords: atrial fibrillation; fibroblasts; fibrosis; mesalamine; osteopontin

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