Front Endocrinol (Lausanne). 2021 Aug 26;12:708139. doi: 10.3389/fendo.2021.708139. eCollection 2021.
The Association of Trp64Arg Polymorphism in the Beta-Adrenergic Receptor With Insulin Resistance: Meta-Analysis.
Frontiers in endocrinology
Hai-Dan Wang, Cai-Shun Zhang, Man-Wen Li, Qian Lin, Qing Zhang, De-Feng Liu, Zheng-Ye Ma, Jing Dong
- Special Medicine Department, Medical College, Qingdao University, Qingdao, China.
- Clinical Medicine Department, Medical College, Qingdao University, Qingdao, China.
- Physiology Department, Medical College, Qingdao University, Qingdao, China.
PMCID: PMC8426512 DOI: 10.3389/fendo.2021.708139
BACKGROUND: Insulin resistance is a metabolic disorder that occurs in type 2 diabetes mellitus and obesity. Genetic factors such as β3-adrenoceptor polymorphism (Trp64Arg) may be involved in IR and insulin secretion. However, their association is controversial. Therefore, the current meta-analysis was conducted to clarify the relationship between the Trp64Arg and IR.
METHODS: The literature search was performed in PubMed, Embase, and Web of Science using the keywords "Receptors, Adrenergic, beta-3, Receptors, Adrenergic, Insulin Resistance, Protein-Coupled Receptor Kinase 3" from 2005 to February 7, 2021. We used a random-effects model to calculate the pooled effect size. We conducted subgroup analysis and regression analysis to identify sources of heterogeneity; and Egger's test and funnel plot were used to test publication bias. Finally, we conducted a sensitivity analysis.
RESULTS: We included eight papers with 1,586 subjects. There was a positive correlation between Trp64Arg mutation and insulin level (standardized mean difference = 0.20, 95% confidence intervals: 0.00 to 0.39,
CONCLUSION: Trp64Arg may be associated with IR. European ancestry, obesity, plasma insulin level, and test status may be potential factors affecting the relationship between Trp64Arg and IR.
Copyright © 2021 Wang, Zhang, Li, Lin, Zhang, Liu, Ma and Dong.
Keywords: Trp64Arg; insulin resistance; meta-analysis; subgroup analysis; β3-adrenergic receptor gene
Conflict of interest statement
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
- Ann Lab Med. 2015 May;35(3):283-7 - PubMed
- J Clin Invest. 1989 Jul;84(1):205-13 - PubMed
- Gynecol Endocrinol. 2008 Mar;24(3):133-8 - PubMed
- Adv Data. 2000 Jun 8;(314):1-27 - PubMed
- J Clin Endocrinol Metab. 1996 Nov;81(11):4155-8 - PubMed
- J Clin Endocrinol Metab. 1998 Jul;83(7):2441-4 - PubMed