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Crit Rev Biochem Mol Biol. 2021 Oct 02;1-20. doi: 10.1080/10409238.2021.1979458. Epub 2021 Oct 02.

Diverse triterpene skeletons are derived from the expansion and divergent evolution of 2,3-oxidosqualene cyclases in plants.

Critical reviews in biochemistry and molecular biology

Jing Wang, Yanhong Guo, Xue Yin, Xiaoning Wang, Xiaoquan Qi, Zheyong Xue

Affiliations

  1. Ministry of Education, Key Laboratory of Saline-alkali Vegetation Ecology Restoration, Northeast Forestry University, Harbin, PR China.
  2. Heilongjiang Key Laboratory of Plant Bioactive Substance Biosynthesis and Utilization, Northeast Forestry University, Harbin, PR China.
  3. Institute of Forestry and Pomology, Beijing Academy of Agriculture and Forestry Sciences, Beijing, PR China.
  4. Department of Natural Product Chemistry, Key Laboratory of Chemical Biology, Ministry of Education, School of Pharmaceutical Sciences, Shandong University, Jinan, PR China.
  5. Key Laboratory of Plant Molecular Physiology, Institute of Botany, Chinese Academy of Sciences, Beijing, PR China.

PMID: 34601979 DOI: 10.1080/10409238.2021.1979458

Abstract

Triterpenoids are one of the largest groups of secondary metabolites and exhibit diverse structures, which are derived from C30 skeletons that are biosynthesized

Keywords: Triterpene; biosynthesis; catalytic mechanism; functional divergence; oxidosqualene cyclase

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