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Duarte G, Muresan P, Ward S, et al. Immunogenicity of conjugated and polysaccharide pneumococcal vaccines administered during pregnancy or postpartum to women with HIV. J Infect Dis. 2021;doi: 10.1093/infdis/jiab567.
Duarte, G., Muresan, P., Ward, S., Laimon, L., Pelton, S. I., Canniff, J., Golner, A., Bone, F., Newton, L., Fenton, T., Coutinho, C. M., João, E. C., Santos, B. R., Pilotto, J. H., Oliveira, R. H., Pinto, J. A., Machado, E. S., Kreitchman, R., Chakhtoura, N., Mussi-Pinhata, M. M., Weinberg, A. (2021). Immunogenicity of conjugated and polysaccharide pneumococcal vaccines administered during pregnancy or postpartum to women with HIV. The Journal of infectious diseases, . https://doi.org/10.1093/infdis/jiab567
Duarte, Geraldo, et al. "Immunogenicity of conjugated and polysaccharide pneumococcal vaccines administered during pregnancy or postpartum to women with HIV." The Journal of infectious diseases vol. (2021). doi: https://doi.org/10.1093/infdis/jiab567
Duarte G, Muresan P, Ward S, Laimon L, Pelton SI, Canniff J, Golner A, Bone F, Newton L, Fenton T, Coutinho CM, João EC, Santos BR, Pilotto JH, Oliveira RH, Pinto JA, Machado ES, Kreitchman R, Chakhtoura N, Mussi-Pinhata MM, Weinberg A. Immunogenicity of conjugated and polysaccharide pneumococcal vaccines administered during pregnancy or postpartum to women with HIV. J Infect Dis. 2021 Nov 16; doi: 10.1093/infdis/jiab567. Epub 2021 Nov 16. PMID: 34791324.
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J Infect Dis. 2021 Nov 16; doi: 10.1093/infdis/jiab567. Epub 2021 Nov 16.

Immunogenicity of conjugated and polysaccharide pneumococcal vaccines administered during pregnancy or postpartum to women with HIV.

The Journal of infectious diseases

Geraldo Duarte, Petronella Muresan, Shawn Ward, Lauren Laimon, Stephen I Pelton, Jennifer Canniff, Amanda Golner, Frederic Bone, Lassallete Newton, Terence Fenton, Conrado M Coutinho, Esau C João, Breno R Santos, Jose H Pilotto, Ricardo H Oliveira, Jorge A Pinto, Elizabeth S Machado, Regis Kreitchman, Nahida Chakhtoura, Marisa M Mussi-Pinhata, Adriana Weinberg,

Affiliations

  1. Department of Obstetrics and Gynecology, Ribeirão Preto Medical School, University of São Paulo, Brazil.
  2. Frontier Science Foundation, Brookline, MA, USA.
  3. Westat, Rockville, MD, USA.
  4. Boston University School of Medicine, Boston, MA, USA.
  5. Department of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
  6. Frontier Science Foundation, Buffalo, NY, USA.
  7. Hospital dos Servidores Estaduais, Rio de Janeiro, RJ, Brazil.
  8. Hospital Nossa Senhora da Conceicao, Porto Alegre, RGS, Brazil.
  9. Hospital Geral de Nova Iguaçu & Laboratório de AIDS e Imunologia Molecular - Fiocruz, Rio de Janeiro, Brazil.
  10. Instituto de Puericultura e Pediatra Matagão Gesteira, Rio de Janeiro, RJ, Brazil.
  11. School of Medicine, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.
  12. Federal University of Health Sciences of Porto Alegre, Brazil.
  13. Eunice Kennedy Shriver National Institute of Child Health & Human Development, Bethesda, MD, USA.
  14. Department of Pediatrics, Ribeirão Preto Medical School, University of São Paulo, Brazil.

PMID: 34791324 DOI: 10.1093/infdis/jiab567

Abstract

BACKGROUND: Pneumococcal vaccination is recommended in people with HIV prioritizing PCV. We compared the immunogenicity of PCV-10 and PPV-23 administered antepartum or postpartum.

METHODS: This double-blind study randomized 346 pregnant women with HIV on antiretrovirals to PCV-10, PPV-23, or placebo at 14-34 weeks gestational age. Women who received placebo antepartum were randomized at 24 weeks postpartum to PCV-10 or PPV-23. Antibodies against seven serotypes common to both vaccines and one serotype only in PPV-23 were measured by ELISA/chemiluminescence; B- and T-cell responses to serotype-1 by FLUOROSPOT; and plasma cytokines/chemokines by chemiluminescence.

RESULTS: Antibody responses were higher after postpartum versus antepartum vaccination. PCV-10 generated lower antibody levels than PPV-23 against four and higher against one of seven common serotypes. Additional factors associated with high post-vaccination antibody concentrations were high pre-vaccination antibody concentrations and CD4+ cells; low CD8+ cells and plasma HIV RNA; and several plasma cytokines/chemokines. Serotype-1 B- and T-cell memory did not increase after vaccination.

CONCLUSIONS: Antepartum immunization generated suboptimal antibody responses, suggesting that postpartum booster doses may be beneficial and warrant further studies. Considering that PCV-10 and PPV-23 had similar immunogenicity, but PPV-23 covered more serotypes, the use of PPV-23 may be prioritized in women with HIV on ART.

© The Author(s) 2021. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: [email protected].

Keywords: ART; HIV infection; PCV; PPV; pregnancy

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