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Ezenwosu O, Chukwu B, Ezenwosu I, et al. Clinical depression in children and adolescents with sickle cell anaemia: influencing factors in a resource-limited setting. BMC Pediatr. 2021;21(1):533doi: 10.1186/s12887-021-03015-1.
Ezenwosu, O., Chukwu, B., Ezenwosu, I., Uwaezuoke, N., Eke, C., Udorah, M., Idoko, C., Ikefuna, A., & Emodi, I. (2021). Clinical depression in children and adolescents with sickle cell anaemia: influencing factors in a resource-limited setting. BMC pediatrics, 21(1), 533. https://doi.org/10.1186/s12887-021-03015-1
Ezenwosu, Osita, et al. "Clinical depression in children and adolescents with sickle cell anaemia: influencing factors in a resource-limited setting." BMC pediatrics vol. 21,1 (2021): 533. doi: https://doi.org/10.1186/s12887-021-03015-1
Ezenwosu O, Chukwu B, Ezenwosu I, Uwaezuoke N, Eke C, Udorah M, Idoko C, Ikefuna A, Emodi I. Clinical depression in children and adolescents with sickle cell anaemia: influencing factors in a resource-limited setting. BMC Pediatr. 2021 Dec 01;21(1):533. doi: 10.1186/s12887-021-03015-1. PMID: 34847910; PMCID: PMC8638467.
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BMC Pediatr. 2021 Dec 01;21(1):533. doi: 10.1186/s12887-021-03015-1.

Clinical depression in children and adolescents with sickle cell anaemia: influencing factors in a resource-limited setting.

BMC pediatrics

Osita Ezenwosu, Barth Chukwu, Ifeyinwa Ezenwosu, Ndubuisi Uwaezuoke, Christopher Eke, Maria Udorah, Chinedu Idoko, Anthony Ikefuna, Ifeoma Emodi

Affiliations

  1. Department of Paediatrics, Faculty of Medical Sciences, College of Medicine, University of Nigeria, Ituku-Ozalla Campus, Enugu, Nigeria. [email protected].
  2. Institute of Maternal and Child Health, University of Nigeria, Ituku-Ozalla Campus, Enugu, Nigeria. [email protected].
  3. Centre for Translational and Implementation Research, University of Nigeria, Enugu, Nigeria. [email protected].
  4. Department of Paediatrics, Faculty of Medical Sciences, College of Medicine, University of Nigeria, Ituku-Ozalla Campus, Enugu, Nigeria.
  5. Department of Community Medicine, University of Nigeria Teaching Hospital, Ituku-Ozalla, Enugu, Nigeria.
  6. Department of Paediatrics, Annunciation Specialist Hospital, Emene, Enugu, Nigeria.

PMID: 34847910 PMCID: PMC8638467 DOI: 10.1186/s12887-021-03015-1

Abstract

BACKGROUND: Sickle cell anaemia (SCA) is the commonest monogenic haematologic disorder resulting from the inheritance of homozygous mutant haemoglobin genes from both parents. Some factors have been identified as important in explaining the variability in depression in sickle cell anaemia (SCA). Information on this is limited in a resource-limited setting like Nigeria. This study aims to determine factors which influence depression in children and adolescents with sickle cell anaemia in a resource-limited setting.

METHODS: Systematic random sampling technique was used in this cross-sectional study to select children and adolescents aged 7-17 years at the weekly sickle cell clinic of the University of Nigeria Teaching hospital (UNTH) Enugu, Nigeria. Pretested, structured questionnaire was used to collect sociodemographic and disease severity data while depression was assessed using the Children's Depression Inventory.

RESULTS: Age and educational level had significant positive linear relationships with depression (r = 0.253, p = 0.02; r = 0.225, p = 0.04 respectively) while gender (χ2 = 0.531, p = 0.466), socioeconomic status (χ2 = 0.451, p = 0.798) and disease severity (χ2 = 0.422, p = 0.810) had no relationship with depression in children and adolescents with SCA.

CONCLUSION: Depression in children and adolescents with SCA increased with increasing age and educational level. Psychological evaluation should be integrated into routine assessment of children with SCA during their follow up visits as they get older and progress in class.

© 2021. The Author(s).

Keywords: Adolescents; Children; Depression; Factors; Sickle cell

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