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Elliott EK, Hopkins LN, Hensen R, et al. Epigenetic Regulation of miR-92a and TET2 and Their Association in Non-Hodgkin Lymphoma. Front Genet. 2021;12:768913doi: 10.3389/fgene.2021.768913.
Elliott, E. K., Hopkins, L. N., Hensen, R., Sutherland, H. G., Haupt, L. M., & Griffiths, L. R. (2021). Epigenetic Regulation of miR-92a and TET2 and Their Association in Non-Hodgkin Lymphoma. Frontiers in genetics, 12768913. https://doi.org/10.3389/fgene.2021.768913
Elliott, Esther K, et al. "Epigenetic Regulation of miR-92a and TET2 and Their Association in Non-Hodgkin Lymphoma." Frontiers in genetics vol. 12 (2021): 768913. doi: https://doi.org/10.3389/fgene.2021.768913
Elliott EK, Hopkins LN, Hensen R, Sutherland HG, Haupt LM, Griffiths LR. Epigenetic Regulation of miR-92a and TET2 and Their Association in Non-Hodgkin Lymphoma. Front Genet. 2021 Nov 26;12:768913. doi: 10.3389/fgene.2021.768913. eCollection 2021. PMID: 34899857; PMCID: PMC8661906.
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Front Genet. 2021 Nov 26;12:768913. doi: 10.3389/fgene.2021.768913. eCollection 2021.

Epigenetic Regulation of miR-92a and TET2 and Their Association in Non-Hodgkin Lymphoma.

Frontiers in genetics

Esther K Elliott, Lloyd N Hopkins, Robert Hensen, Heidi G Sutherland, Larisa M Haupt, Lyn R Griffiths

Affiliations

  1. Centre for Genomics and Personalised Health, Genomics Research Centre, School of Biomedical Sciences, Queensland University of Technology (QUT), Kelvin Grove, QLD, Australia.
  2. Icon Cancer Centre, Brisbane, QLD, Australia.

PMID: 34899857 PMCID: PMC8661906 DOI: 10.3389/fgene.2021.768913

Abstract

MicroRNAs (miRNAs) are well known for their ability to regulate the expression of specific target genes through degradation or inhibition of translation of the target mRNA. In various cancers, miRNAs regulate gene expression by altering the epigenetic status of candidate genes that are implicated in various difficult to treat haematological malignancies such as non-Hodgkin lymphoma by acting as either oncogenes or tumour suppressor genes. Cellular and circulating miRNA biomarkers could also be directly utilised as disease markers for diagnosis and monitoring of non-Hodgkin lymphoma (NHL); however, the role of DNA methylation in miRNA expression regulation in NHL requires further scientific inquiry. In this study, we investigated the methylation levels of CpGs in CpG islands spanning the promoter regions of the miR-17-92 cluster host gene and the TET2 gene and correlated them with the expression levels of

Copyright © 2021 Elliott, Hopkins, Hensen, Sutherland, Haupt and Griffiths.

Keywords: Burkitt lymphoma; DNA methylation; diffuse large B-cell lymphoma; epigenetic regulation; mantle cell lymphoma; miR-17∼92; micro-RNA (miRNA/miR)

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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