Display options
Cite
Barth E, Srivastava A, Wengerodt D, et al. Age-dependent expression changes of circadian system-related genes reveal a potentially conserved link to aging. Aging (Albany NY). 2021;13doi: 10.18632/aging.203788.
Barth, E., Srivastava, A., Wengerodt, D., Stojiljkovic, M., Axer, H., Witte, O. W., Kretz, A., & Marz, M. (2021). Age-dependent expression changes of circadian system-related genes reveal a potentially conserved link to aging. Aging, 13. https://doi.org/10.18632/aging.203788
Barth, Emanuel, et al. "Age-dependent expression changes of circadian system-related genes reveal a potentially conserved link to aging." Aging vol. 13 (2021). doi: https://doi.org/10.18632/aging.203788
Barth E, Srivastava A, Wengerodt D, Stojiljkovic M, Axer H, Witte OW, Kretz A, Marz M. Age-dependent expression changes of circadian system-related genes reveal a potentially conserved link to aging. Aging (Albany NY). 2021 Dec 19;13. doi: 10.18632/aging.203788. Epub 2021 Dec 19. PMID: 34923482.
Copy Download .nbib Format: NLM
Share it on

Aging (Albany NY). 2021 Dec 19;13. doi: 10.18632/aging.203788. Epub 2021 Dec 19.

Age-dependent expression changes of circadian system-related genes reveal a potentially conserved link to aging.

Aging

Emanuel Barth, Akash Srivastava, Diane Wengerodt, Milan Stojiljkovic, Hubertus Axer, Otto W Witte, Alexandra Kretz, Manja Marz

Affiliations

  1. Bioinformatics/High Throughput Analysis, Faculty of Mathematics and Computer Science, Friedrich Schiller University Jena, Jena, Germany.
  2. FLI Leibniz Institute for Age Research, Jena, Germany.
  3. Hans Berger Department of Neurology, Jena University Hospital, Jena, Germany.
  4. German Center for Integrative Biodiversity Research (iDiv), Halle-Jena-Leipzig, Germany.
  5. European Virus Bioinformatics Center (EVBC), Jena, Germany.

PMID: 34923482 DOI: 10.18632/aging.203788

Abstract

The circadian clock system influences the biology of life by establishing circadian rhythms in organisms, tissues, and cells, thus regulating essential biological processes based on the day/night cycle. Circadian rhythms change over a lifetime due to maturation and aging, and disturbances in the control of the circadian system are associated with several age-related pathologies. However, the impact of chronobiology and the circadian system on healthy organ and tissue aging remains largely unknown. Whether aging-related changes of the circadian system's regulation follow a conserved pattern across different species and tissues, hence representing a common driving force of aging, is unclear. Based on a cross-sectional transcriptome analysis covering 329 RNA-Seq libraries, we provide indications that the circadian system is subjected to aging-related gene alterations shared between evolutionarily distinct species, such as

Keywords: RNA-Seq; aging; circadian clock system; circadian rhythm; inter-species comparison; longevity

Publication Types