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Rasouli N, Brodsky IG, Chatterjee R, et al. Effects of Vitamin D Supplementation on Insulin Sensitivity and Secretion in Prediabetes. J Clin Endocrinol Metab. 2022;107(1):230-240doi: 10.1210/clinem/dgab649.
Rasouli, N., Brodsky, I. G., Chatterjee, R., Kim, S. H., Pratley, R. E., Staten, M. A., Pittas, A. G. (2022). Effects of Vitamin D Supplementation on Insulin Sensitivity and Secretion in Prediabetes. The Journal of clinical endocrinology and metabolism, 107(1), 230-240. https://doi.org/10.1210/clinem/dgab649
Rasouli, Neda, et al. "Effects of Vitamin D Supplementation on Insulin Sensitivity and Secretion in Prediabetes." The Journal of clinical endocrinology and metabolism vol. 107,1 (2022): 230-240. doi: https://doi.org/10.1210/clinem/dgab649
Rasouli N, Brodsky IG, Chatterjee R, Kim SH, Pratley RE, Staten MA, Pittas AG. Effects of Vitamin D Supplementation on Insulin Sensitivity and Secretion in Prediabetes. J Clin Endocrinol Metab. 2022 Jan 01;107(1):230-240. doi: 10.1210/clinem/dgab649. PMID: 34473295; PMCID: PMC8684490.
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J Clin Endocrinol Metab. 2022 Jan 01;107(1):230-240. doi: 10.1210/clinem/dgab649.

Effects of Vitamin D Supplementation on Insulin Sensitivity and Secretion in Prediabetes.

The Journal of clinical endocrinology and metabolism

Neda Rasouli, Irwin G Brodsky, Ranee Chatterjee, Sun H Kim, Richard E Pratley, Myrlene A Staten, Anastassios G Pittas,

Affiliations

  1. Division of Endocrinology, Metabolism and Diabetes, University of Colorado School of Medicine and VA Eastern Colorado Health Care System, Aurora, CO 80045, USA.
  2. Endocrinology and Diabetes Center, Maine Medical Center and Maine Medical Center Research Institute, Scarborough, ME 04101, USA.
  3. Department of Medicine, Duke University, Durham, NC 27713, USA.
  4. Division of Endocrinology, Gerontology and Metabolism, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.
  5. AdventHealth Translational Research Institute, Orlando, FL 32804, USA.
  6. National Institute of Diabetes and Digestive, and Kidney Diseases, Bethesda, MD 20892 (retired), USA.
  7. Division of Endocrinology, Diabetes and Metabolism, Tufts Medical Center, Boston, MA 02111, USA.

PMID: 34473295 PMCID: PMC8684490 DOI: 10.1210/clinem/dgab649

Abstract

CONTEXT: Vitamin D regulates glucose homeostasis pathways, but effects of vitamin D supplementation on β-cell function remain unclear.

OBJECTIVE: To investigate the effects of vitamin D3 supplementation on insulin sensitivity and β-cell function.

METHODS: This is a prespecified secondary analysis of the Vitamin D and Type 2 Diabetes study. Overweight/obese adults at high risk for type 2 diabetes (prediabetes) were randomly treated with vitamin D3 4000 IU or matching placebo daily for 24 months.

MAIN OUTCOME: Disposition index (DI), as an estimate of β-cell function, was calculated as the product of Homeostasis Model Assessment 2 indices derived from C-peptide values (HOMA2%Scpep) and C-peptide response during the first 30 minutes of a 75-g oral glucose tolerance test (OGTT).

RESULTS: Mean age was 60.5 ± 9.8 years and body mass index was 31.9 ± 4.4 kg/m2. Mean serum 25(OH)D level increased from 27.9 ± 10.3 ng/mL at baseline to 54.9 ng/mL at 2 years in the vitamin D group and was unchanged (28.5 ± 10.0 ng/mL) in the placebo group. The baseline DI predicted incident diabetes independent of the intervention. In the entire cohort, there were no significant differences in changes in DI, HOMA2%Scpep, or C-peptide response between the 2 groups. Among participants with baseline 25(OH)D level <12 ng/mL, the mean percent differences for DI between the vitamin D and placebo groups was 8.5 (95% CI, 0.2-16.8).

CONCLUSIONS: Supplementation with vitamin D3 for 24 months did not improve an OGTT-derived index of β-cell function in people with prediabetes not selected based on baseline vitamin D status; however, there was benefit among those with very low baseline vitamin D status.

© The Author(s) 2021. Published by Oxford University Press on behalf of the Endocrine Society. All rights reserved. For permissions, please e-mail: [email protected].

Keywords: beta-cell function; insulin sensitivity; prediabetes; vitamin D

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