Chemioterapia. 1986 Dec;5(6):411-3.

Evaluation of the cochleovestibular function in patients treated with carboplatin for ovarian carcinoma.

Chemioterapia : international journal of the Mediterranean Society of Chemotherapy

N Ragni, G Foglia, M Ruvolo, P Repetto, G Cordone, M Madaro, S Chiara, M Bruzzone

PMID: 3542253

Abstract

Carboplatin (JM8), a new cisdiamminodichloroplatin (CDDP) analogue, has exhibited the same antitumor as CDDP. In our pilot study, aiming at optimizing the dosage of this drug in a combination regimen with other chemotherapics, we planned to evaluate the existence of drug related damage on cochleo-vestibular structures. The study was performed on 9 patients suffering from advanced ovarian carcinoma. The results obtained in our study showed that patients undergoing carboplatin chemotherapy do not require an audiometric check-up. In order to assess definitely the existence of vestibular toxicity of this drug, larger studies planned to test JM8 in a high-dosage regimen are desirable.

Substances

• Antineoplastic Agents
• Organoplatinum Compounds
• Carboplatin

MeSH terms

• Aged
• Antineoplastic Agents / therapeutic use
• Carboplatin
• Cochlea / drug effects
• Female
• Hearing Disorders / chemically induced
• Hearing Tests
• Humans
• Middle Aged
• Organoplatinum Compounds / adverse effects
• Organoplatinum Compounds / therapeutic use
• Ovarian Neoplasms / drug therapy
• Vestibule, Labyrinth / drug effects

Publication Types

• Journal Article
• Research Support, Non-U.S. Gov't

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