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Franke F, Rudolph B, Christiansen H, et al. Tumour karyotype may be important in the prognosis of human neuroblastoma. J Cancer Res Clin Oncol. 1986;111(3):266-72doi: 10.1007/BF00389243.
Franke, F., Rudolph, B., Christiansen, H., Harbott, J., & Lampert, F. (1986). Tumour karyotype may be important in the prognosis of human neuroblastoma. Journal of cancer research and clinical oncology, 111(3), 266-72. https://doi.org/10.1007/BF00389243
Franke, F, et al. "Tumour karyotype may be important in the prognosis of human neuroblastoma." Journal of cancer research and clinical oncology vol. 111,3 (1986): 266-72. doi: https://doi.org/10.1007/BF00389243
Franke F, Rudolph B, Christiansen H, Harbott J, Lampert F. Tumour karyotype may be important in the prognosis of human neuroblastoma. J Cancer Res Clin Oncol. 1986;111(3):266-72. doi: 10.1007/BF00389243. PMID: 3733856.
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J Cancer Res Clin Oncol. 1986;111(3):266-72. doi: 10.1007/BF00389243.

Tumour karyotype may be important in the prognosis of human neuroblastoma.

Journal of cancer research and clinical oncology

F Franke, B Rudolph, H Christiansen, J Harbott, F Lampert

PMID: 3733856 DOI: 10.1007/BF00389243

Abstract

When comparing clinical and tumour cytogenetic data on 14 neuroblastoma patients in different stages of disease we found a high incidence of 1p abnormalities (12/12), homogeneously staining regions/double minutes (9/12) and 2p abnormalities (4/12) in 12 unresectable and metastatic tumours (clinical stages III and IV). In contrast, these features were absent in clinical stage II tumours (2/2) with good prognosis. The coincidence of 1p aberrations with poor outcome of disease will be discussed.

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