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Ray WA, O'Day DM. Statistical analysis of multi-eye data in ophthalmic research. Invest Ophthalmol Vis Sci. 1985;26(8):1186-8
Ray, W. A., & O'Day, D. M. (1985). Statistical analysis of multi-eye data in ophthalmic research. Investigative ophthalmology & visual science, 26(8), 1186-8.
Ray, W A, and O'Day, D M. "Statistical analysis of multi-eye data in ophthalmic research." Investigative ophthalmology & visual science vol. 26,8 (1985): 1186-8.
Ray WA, O'Day DM. Statistical analysis of multi-eye data in ophthalmic research. Invest Ophthalmol Vis Sci. 1985 Aug;26(8):1186-8. PMID: 4019113.
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Invest Ophthalmol Vis Sci. 1985 Aug;26(8):1186-8.

Statistical analysis of multi-eye data in ophthalmic research.

Investigative ophthalmology & visual science

W A Ray, D M O'Day

PMID: 4019113

Abstract

An apparently common error in statistical analysis of ophthalmic data is to perform statistical tests that do not account for the correlation generally present between observations made for the right and left eyes of a subject. This error has as a consequence an overstatement of the precision of the study, resulting in incorrect P values which indicate a greater measure of statistical significance than the data warrant. As measures to reduce the occurrence of this serious error in statistical analyses, the authors recommend increased emphasis on educational programs for investigators, stimulation of nontechnical articles reviewing statistical methods, and a sharper focus upon statistical analysis in the peer review process.

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