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Jaenke RS, Alexander AF. Fine structural alterations of bovine peripheral pulmonary arteries in hypoxia-induced hypertension. Am J Pathol. 1973;73(2):377-98
Jaenke, R. S., & Alexander, A. F. (1973). Fine structural alterations of bovine peripheral pulmonary arteries in hypoxia-induced hypertension. The American journal of pathology, 73(2), 377-98.
Jaenke, R S, and Alexander, A F. "Fine structural alterations of bovine peripheral pulmonary arteries in hypoxia-induced hypertension." The American journal of pathology vol. 73,2 (1973): 377-98.
Jaenke RS, Alexander AF. Fine structural alterations of bovine peripheral pulmonary arteries in hypoxia-induced hypertension. Am J Pathol. 1973 Nov;73(2):377-98. PMID: 4357176; PMCID: PMC1904060.
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Am J Pathol. 1973 Nov;73(2):377-98.

Fine structural alterations of bovine peripheral pulmonary arteries in hypoxia-induced hypertension.

The American journal of pathology

R S Jaenke, A F Alexander

PMID: 4357176 PMCID: PMC1904060
Free PMC Article

Abstract

Cellular alterations of the distal bovine pulmonary arteries in hypoxia-induced pulmonary hypertension were studied. These lesions were related to pulmonary hemodynamic changes and contrasted to the cellular response observed in hyperkinetic pulmonary and systemic hypertension as well as other forms of vascular injury. Medial thickening and mild adventitial proliferation with an absence of intimal proliferative lesions related to a progressive increase in mean pulmonary arterial pressure and pulmonary vascular resistance were observed. Smooth muscle and endothelial cells exhibited distinct degenerative alterations in response to the maintained hypertensive state resulting from the lowered alveolar oxygen tension.

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