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Identification of ChIP-seq mapped targets of HP1β due to bombesin/GRP receptor activation.

Clinical epigenetics

Tell R, Wang QT, Blunier A, Benya RV.
PMID: 22704345
Clin Epigenetics. 2011 Aug;2(2):331-8. doi: 10.1007/s13148-011-0027-5. Epub 2011 Mar 29.

Epithelial cells lining the adult colon do not normally express gastrin-releasing peptide (GRP) or its receptor (GRPR). In contrast, GRP/GRPR can be aberrantly expressed in human colorectal cancer (CRC) including Caco-2 cells. We have previously shown that GRPR activation...

Sulfakinins reduce food intake in the desert locust, Schistocerca gregaria.

Journal of insect physiology

Wei Z, Baggerman G, J Nachman R, Goldsworthy G, Verhaert P, De Loof A, Schoofs L.
PMID: 10844144
J Insect Physiol. 2000 Sep 01;46(9):1259-1265. doi: 10.1016/s0022-1910(00)00046-9.

In vertebrates, the peptides cholecystokinin (CCK), neuropeptide Y, galanin, and bombesin are known to be involved in the control of food intake. We report here that insect sulfakinins, peptides which display substantial sequence similarities with the vertebrate gastrin/CCK peptide...

Localization of putative biochemical messengers during Eisenia foetida (Annelida, Oligochaeta) development.

Tissue & cell

Falugi C, Davoli C.
PMID: 18621234
Tissue Cell. 1993 Jun;25(3):311-23. doi: 10.1016/0040-8166(93)90073-t.

This histochemical-immunohistochemical study was performed on the earthworm Eisenia foetida at different developmental stages, to investigate the presence and distribution of cholinergic molecules (AChE, BuChE, alpha-bungarotoxin-binding sites), several biogenic amines (5HT and catecholamines), and some immunologically-related peptides (somatostatin. FMRF-amide,...

Neuromedin: An insight into its types, receptors and therapeutic opportunities.

Pharmacological reports : PR

Gajjar S, Patel BM.
PMID: 31994106
Pharmacol Rep. 2017 May;69(3):438-447. doi: 10.1016/j.pharep.2017.01.009. Epub 2017 Jan 22.

Neuropeptides are small protein used by neurons in signal communications. Neuromedin U was the first neuropeptide discovered from the porcine spinal and showed its potent constricting activities on uterus hence was entitled with neuromedin U. Following neuromedin U another...

Autoradiographic localization of neuromedin B binding sites in rat brain.

Molecular and cellular neurosciences

Lee MC, Jensen RT, Coy DH, Moody TW.
PMID: 19912767
Mol Cell Neurosci. 1990 Oct;1(2):161-7. doi: 10.1016/1044-7431(90)90021-u.

The binding properties and autoradiographic distribution of radiolabeled neuromedin B (NMB) to rat brain sections were investigated. (125)I-NMB bound with high affinity (K(d) = 1 nM) to a single class of sites (B(max) = 80 fmol/mg protein) in coronal...

Targeting the gastrin-releasing peptide receptor pathway to treat cognitive dysfunctionassociated with Alzheimer's Disease.

Dementia & neuropsychologia

Roesler R, Luft T, Schwartsmann G.
PMID: 29213377
Dement Neuropsychol. 2007 Apr-Jun;1(2):118-123. doi: 10.1590/s1980-57642008dn10200002.

Increasing evidence indicates that bombesin (BB)-like peptides (BLPs), such as the gastrin-releasing peptide (GRP) and its receptor (GRPR), might play a role in neurological and psychiatric disorders. The present study reviews findings from animal and human studies suggesting that...

Dexamethasone treatment after adrenalectomy increases bombesin content in the rat spinal cord.

Acta physiologica Scandinavica

Westermark T, Isaksson T, Holmberg P, Kjörell U, Rantapää-Dahlqvist S, Forsgren S.
PMID: 10571562
Acta Physiol Scand. 1999 Oct;167(2):A8. doi: 10.1046/j.1365-201x.1999.0600h.x.

No abstract available.

Gut hormones in cyclostomes.

Fish physiology and biochemistry

Van Noorden S.
PMID: 24220989
Fish Physiol Biochem. 1990 Sep;8(5):399-408. doi: 10.1007/BF00003371.

The current state of knowledge about regulatory peptides in endocrine cells and nerves of the alimentary canal of lampreys and hagfishes is reviewed. Cyclostomes have a wide range of peptides similar immunochemically to those of higher vertebrates. They include,...

Radiolabeled peptides: valuable tools for the detection and treatment of cancer.


Fani M, Maecke HR, Okarvi SM.
PMID: 22737187
Theranostics. 2012;2(5):481-501. doi: 10.7150/thno.4024. Epub 2012 May 16.

Human cancer cells overexpress many peptide receptors as molecular targets. Radiolabeled peptides that bind with high affinity and specificity to the receptors on tumor cells hold great potential for both diagnostic imaging and targeted radionuclide therapy. The advantage of...

Interactions of gastrointestinal peptides: ghrelin and its anorexigenic antagonists.

International journal of peptides

Wisser AS, Habbel P, Wiedenmann B, Klapp BF, Mönnikes H, Kobelt P.
PMID: 20798884
Int J Pept. 2010;2010. doi: 10.1155/2010/817457. Epub 2010 Jan 06.

Food intake behaviour and energy homeostasis are strongly regulated by a complex system of humoral factors and nerval structures constituting the brain-gut-axis. To date the only known peripherally produced and centrally acting peptide that stimulates food intake is ghrelin,...

Endocrine cells and nerves in the stomach of the lizard Podarcis hispanica detected by immunocytochemistry.

Tissue & cell

De Rada OD, Burrell MA, García C, Barrenechea MA, Sesma P.
PMID: 18621220
Tissue Cell. 1992;24(5):705-13. doi: 10.1016/0040-8166(92)90041-5.

The general identification of endocrine cells in the stomach of the lizard Podarcis hispanica was carried out by their response to the Grimelius and Masson-Fontana techniques. 11 immunoreactive cell-types, positive for chromogranin-, serotonin-, caerulein/gastrin/ cholecystokinin (CAER/G/CCK)-, glucagon-like-peptide-1 (GLP-1)-. glucagon-,...

AM-37 and ST-36 Are Small Molecule Bombesin Receptor Antagonists.

Frontiers in endocrinology

Moody TW, Tashakkori N, Mantey SA, Moreno P, Ramos-Alvarez I, Leopoldo M, Jensen RT.
PMID: 28785244
Front Endocrinol (Lausanne). 2017 Jul 21;8:176. doi: 10.3389/fendo.2017.00176. eCollection 2017.

While peptide antagonists for the gastrin-releasing peptide receptor (BB

Showing 25 to 36 of 575 entries