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Showing 25 to 29 of 29 entries
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Cancer cells dysregulate PI3K/AKT/mTOR pathway activation to ensure their survival and proliferation: mimicking them is a smart strategy of gammaherpesviruses.

Critical reviews in biochemistry and molecular biology

Cirone M.
PMID: 34130564
Crit Rev Biochem Mol Biol. 2021 Oct;56(5):500-509. doi: 10.1080/10409238.2021.1934811. Epub 2021 Jun 15.

The serine/threonine kinase mammalian target of rapamycin (mTOR) is the catalytic subunit of two complexes, mTORC1 and mTORC2, which have common and distinct subunits that mediate separate and overlapping functions. mTORC1 is activated by plenty of nutrients, and the...

Mechanisms of hexameric helicases.

Critical reviews in biochemistry and molecular biology

Fernandez AJ, Berger JM.
PMID: 34404299
Crit Rev Biochem Mol Biol. 2021 Dec;56(6):621-639. doi: 10.1080/10409238.2021.1954597. Epub 2021 Aug 17.

Ring-shaped hexameric helicases are essential motor proteins that separate duplex nucleic acid strands for DNA replication, recombination, and transcriptional regulation. Two evolutionarily distinct lineages of these enzymes, predicated on RecA and AAA+ ATPase folds, have been identified and characterized...

Cellular mechanisms of mtDNA heteroplasmy dynamics.

Critical reviews in biochemistry and molecular biology

Pereira CV, Gitschlag BL, Patel MR.
PMID: 34120542
Crit Rev Biochem Mol Biol. 2021 Oct;56(5):510-525. doi: 10.1080/10409238.2021.1934812. Epub 2021 Jun 13.

Heteroplasmy refers to the coexistence of more than one variant of the mitochondrial genome (mtDNA). Mutated or partially deleted mtDNAs can induce chronic metabolic impairment and cause mitochondrial diseases when their heteroplasmy levels exceed a critical threshold. These mutant...

Capillary Electrophoretic Analysis of Isolated Sulfated Polysaccharides to Characterize Pharmaceutical Products.

Methods in molecular biology (Clifton, N.J.)

Shriver Z, Sasisekharan R.
PMID: 34626391
Methods Mol Biol. 2022;2303:329-339. doi: 10.1007/978-1-0716-1398-6_27.

Capillary electrophoresis is a powerful methodology for quantification and structural characterization of highly anionic polysaccharides. Separation of saccharides under conditions of electrophoretic flow, typically achieved under low pH (Ampofo et al., Anal Biochem 199: 249-255, 1991; Rhomberg et al.,...

Ribosome-associated quality control and CAT tailing.

Critical reviews in biochemistry and molecular biology

Howard CJ, Frost A.
PMID: 34233554
Crit Rev Biochem Mol Biol. 2021 Dec;56(6):603-620. doi: 10.1080/10409238.2021.1938507. Epub 2021 Jul 07.

Translation is the set of mechanisms by which ribosomes decode genetic messages as they synthesize polypeptides of a defined amino acid sequence. While the ribosome has been honed by evolution for high-fidelity translation, errors are inevitable. Aberrant mRNAs, mRNA...

Showing 25 to 29 of 29 entries