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Regression of human colon cancer xenografts in SCID mice following oral administration of water-insoluble camptothecins.

International journal of oncology

Cai Q, Lindsey R, Zhang R.
PMID: 21533469
Int J Oncol. 1997 May;10(5):953-60. doi: 10.3892/ijo.10.5.953.

Gastrointestinal cancers pose major public health problems worldwide, in part because little progress has been made in the treatment of colorectal cancers. The present study explored the potential use of natural product topoisomerase I inhibitors, 10-hydroxycamptothecin (HCPT) and camptothecin...

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Cai Q, Lindsey R, Zhang R. Regression of human colon cancer xenografts in SCID mice following oral administration of water-insoluble camptothecins. Int J Oncol. 1997;10(5):953-60doi: 10.3892/ijo.10.5.953.
Cai, Q., Lindsey, R., & Zhang, R. (1997). Regression of human colon cancer xenografts in SCID mice following oral administration of water-insoluble camptothecins. International journal of oncology, 10(5), 953-60. https://doi.org/10.3892/ijo.10.5.953
Cai, Q, et al. "Regression of human colon cancer xenografts in SCID mice following oral administration of water-insoluble camptothecins." International journal of oncology vol. 10,5 (1997): 953-60. doi: https://doi.org/10.3892/ijo.10.5.953
Cai Q, Lindsey R, Zhang R. Regression of human colon cancer xenografts in SCID mice following oral administration of water-insoluble camptothecins. Int J Oncol. 1997 May;10(5):953-60. doi: 10.3892/ijo.10.5.953. PMID: 21533469.
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Simultaneous assessment of compound activity on cardiac Nav1.5 peak and late currents in an automated patch clamp platform.

Journal of pharmacological and toxicological methods

Guo D, Jenkinson S.
PMID: 30999054
J Pharmacol Toxicol Methods. 2019 Sep - Oct;99:106575. doi: 10.1016/j.vascn.2019.04.001. Epub 2019 Apr 15.

INTRODUCTION: High throughput in vitro profiling of the cardiac Nav1.5 peak sodium current (IMETHODS: The planar patch clamp technique (QPatch) was applied to record the peak and late IRESULTS: The Nav1.5-∆KPQ mutant produced a small late IDISCUSSION: In the...

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Guo D, Jenkinson S. Simultaneous assessment of compound activity on cardiac Nav1.5 peak and late currents in an automated patch clamp platform. J Pharmacol Toxicol Methods. 2019;99:106575doi: 10.1016/j.vascn.2019.04.001.
Guo, D., & Jenkinson, S. (2019). Simultaneous assessment of compound activity on cardiac Nav1.5 peak and late currents in an automated patch clamp platform. Journal of pharmacological and toxicological methods, 99106575. https://doi.org/10.1016/j.vascn.2019.04.001
Guo, Donglin, and Jenkinson, Stephen. "Simultaneous assessment of compound activity on cardiac Nav1.5 peak and late currents in an automated patch clamp platform." Journal of pharmacological and toxicological methods vol. 99 (2019): 106575. doi: https://doi.org/10.1016/j.vascn.2019.04.001
Guo D, Jenkinson S. Simultaneous assessment of compound activity on cardiac Nav1.5 peak and late currents in an automated patch clamp platform. J Pharmacol Toxicol Methods. 2019 Sep - Oct;99:106575. doi: 10.1016/j.vascn.2019.04.001. Epub 2019 Apr 15. PMID: 30999054.
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2019 2nd Americas Conference on Medical Imaging and Clinical Research (AMICR 2019), 9-10 August 2019, Toronto, Canada.

Basic & clinical pharmacology & toxicology

[No authors listed]
PMID: 31397076
Basic Clin Pharmacol Toxicol. 2019 Aug;125:3-330. doi: 10.1111/bcpt.13297.

No abstract available.

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2019 2nd Americas Conference on Medical Imaging and Clinical Research (AMICR 2019), 9-10 August 2019, Toronto, Canada. Basic Clin Pharmacol Toxicol. 2019;125:3-330doi: 10.1111/bcpt.13297.
(2019). 2019 2nd Americas Conference on Medical Imaging and Clinical Research (AMICR 2019), 9-10 August 2019, Toronto, Canada. Basic & clinical pharmacology & toxicology, 1253-330. https://doi.org/10.1111/bcpt.13297
"2019 2nd Americas Conference on Medical Imaging and Clinical Research (AMICR 2019), 9-10 August 2019, Toronto, Canada." Basic & clinical pharmacology & toxicology vol. 125 (2019): 3-330. doi: https://doi.org/10.1111/bcpt.13297
2019 2nd Americas Conference on Medical Imaging and Clinical Research (AMICR 2019), 9-10 August 2019, Toronto, Canada. Basic Clin Pharmacol Toxicol. 2019 Aug;125:3-330. doi: 10.1111/bcpt.13297. PMID: 31397076.
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Electrophysiological characterization of drug response in hSC-derived cardiomyocytes using voltage-sensitive optical platforms.

Journal of pharmacological and toxicological methods

Pfeiffer-Kaushik ER, Smith GL, Cai B, Dempsey GT, Hortigon-Vinagre MP, Zamora V, Feng S, Ingermanson R, Zhu R, Hariharan V, Nguyen C, Pierson J, Gintant GA, Tung L.
PMID: 31319140
J Pharmacol Toxicol Methods. 2019 Sep - Oct;99:106612. doi: 10.1016/j.vascn.2019.106612. Epub 2019 Jul 15.

INTRODUCTION: Voltage-sensitive optical (VSO) sensors offer a minimally invasive method to study the time course of repolarization of the cardiac action potential (AP). This Comprehensive in vitro Proarrhythmia Assay (CiPA) cross-platform study investigates protocol design and measurement variability of...

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Pfeiffer-Kaushik ER, Smith GL, Cai B, et al. Electrophysiological characterization of drug response in hSC-derived cardiomyocytes using voltage-sensitive optical platforms. J Pharmacol Toxicol Methods. 2019;99:106612doi: 10.1016/j.vascn.2019.106612.
Pfeiffer-Kaushik, E. R., Smith, G. L., Cai, B., Dempsey, G. T., Hortigon-Vinagre, M. P., Zamora, V., Feng, S., Ingermanson, R., Zhu, R., Hariharan, V., Nguyen, C., Pierson, J., Gintant, G. A., & Tung, L. (2019). Electrophysiological characterization of drug response in hSC-derived cardiomyocytes using voltage-sensitive optical platforms. Journal of pharmacological and toxicological methods, 99106612. https://doi.org/10.1016/j.vascn.2019.106612
Pfeiffer-Kaushik, Emily R, et al. "Electrophysiological characterization of drug response in hSC-derived cardiomyocytes using voltage-sensitive optical platforms." Journal of pharmacological and toxicological methods vol. 99 (2019): 106612. doi: https://doi.org/10.1016/j.vascn.2019.106612
Pfeiffer-Kaushik ER, Smith GL, Cai B, Dempsey GT, Hortigon-Vinagre MP, Zamora V, Feng S, Ingermanson R, Zhu R, Hariharan V, Nguyen C, Pierson J, Gintant GA, Tung L. Electrophysiological characterization of drug response in hSC-derived cardiomyocytes using voltage-sensitive optical platforms. J Pharmacol Toxicol Methods. 2019 Sep - Oct;99:106612. doi: 10.1016/j.vascn.2019.106612. Epub 2019 Jul 15. PMID: 31319140.
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One non-believer: Response to "Obviously Nine Believers: Actionable Germline Genetic Variants for Pre-emptive Pharmacogenetic Testing".

Basic & clinical pharmacology & toxicology

van der Wouden CH, van Rhenen MH, Jama WOM, Ingelman-Sundberg M, Lauschke VM, Konta L, Schwab M, Swen JJ, Guchelaar HJ.
PMID: 31670867
Basic Clin Pharmacol Toxicol. 2019 Oct 31; doi: 10.1111/bcpt.13336. Epub 2019 Oct 31.

No abstract available.

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van der Wouden CH, van Rhenen MH, Jama WOM, et al. One non-believer: Response to "Obviously Nine Believers: Actionable Germline Genetic Variants for Pre-emptive Pharmacogenetic Testing". Basic Clin Pharmacol Toxicol. 2019;doi: 10.1111/bcpt.13336.
van der Wouden, C. H., van Rhenen, M. H., Jama, W. O. M., Ingelman-Sundberg, M., Lauschke, V. M., Konta, L., Schwab, M., Swen, J. J., & Guchelaar, H. J. (2019). One non-believer: Response to "Obviously Nine Believers: Actionable Germline Genetic Variants for Pre-emptive Pharmacogenetic Testing". Basic & clinical pharmacology & toxicology, . https://doi.org/10.1111/bcpt.13336
van der Wouden, Cathelijne H, et al. "One non-believer: Response to "Obviously Nine Believers: Actionable Germline Genetic Variants for Pre-emptive Pharmacogenetic Testing"." Basic & clinical pharmacology & toxicology vol. (2019). doi: https://doi.org/10.1111/bcpt.13336
van der Wouden CH, van Rhenen MH, Jama WOM, Ingelman-Sundberg M, Lauschke VM, Konta L, Schwab M, Swen JJ, Guchelaar HJ. One non-believer: Response to "Obviously Nine Believers: Actionable Germline Genetic Variants for Pre-emptive Pharmacogenetic Testing". Basic Clin Pharmacol Toxicol. 2019 Oct 31; doi: 10.1111/bcpt.13336. Epub 2019 Oct 31. PMID: 31670867.
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Translatability of the S7A core battery respiratory safety pharmacology studies: Preclinical respiratory and related clinical adverse events.

Journal of pharmacological and toxicological methods

Paglialunga S, Morimoto BH, Clark M, Friedrichs GS.
PMID: 31173885
J Pharmacol Toxicol Methods. 2019 Sep - Oct;99:106596. doi: 10.1016/j.vascn.2019.106596. Epub 2019 Jun 05.

INTRODUCTION: Before entering into first-in-human studies, most new chemical entities must undergo a series of preclinical evaluations. ICH S7A safety pharmacology (SP) guidelines, adopted in 2001, include respiratory assessments as part of the core battery. Despite these safety measures...

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Paglialunga S, Morimoto BH, Clark M, et al. Translatability of the S7A core battery respiratory safety pharmacology studies: Preclinical respiratory and related clinical adverse events. J Pharmacol Toxicol Methods. 2019;99:106596doi: 10.1016/j.vascn.2019.106596.
Paglialunga, S., Morimoto, B. H., Clark, M., & Friedrichs, G. S. (2019). Translatability of the S7A core battery respiratory safety pharmacology studies: Preclinical respiratory and related clinical adverse events. Journal of pharmacological and toxicological methods, 99106596. https://doi.org/10.1016/j.vascn.2019.106596
Paglialunga, Sabina, et al. "Translatability of the S7A core battery respiratory safety pharmacology studies: Preclinical respiratory and related clinical adverse events." Journal of pharmacological and toxicological methods vol. 99 (2019): 106596. doi: https://doi.org/10.1016/j.vascn.2019.106596
Paglialunga S, Morimoto BH, Clark M, Friedrichs GS. Translatability of the S7A core battery respiratory safety pharmacology studies: Preclinical respiratory and related clinical adverse events. J Pharmacol Toxicol Methods. 2019 Sep - Oct;99:106596. doi: 10.1016/j.vascn.2019.106596. Epub 2019 Jun 05. PMID: 31173885.
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Toxicology Meets Pharmacodynamics and Pharmacokinetics - New Concepts, Models and In Vitro Approaches and Tools.

Basic & clinical pharmacology & toxicology

Heinonen T, Pelkonen O, Tähti H.
PMID: 29938893
Basic Clin Pharmacol Toxicol. 2018 Sep;123:3-5. doi: 10.1111/bcpt.13080. Epub 2018 Aug 22.

No abstract available.

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Heinonen T, Pelkonen O, Tähti H. Toxicology Meets Pharmacodynamics and Pharmacokinetics - New Concepts, Models and In Vitro Approaches and Tools. Basic Clin Pharmacol Toxicol. 2018;123:3-5doi: 10.1111/bcpt.13080.
Heinonen, T., Pelkonen, O., & Tähti, H. (2018). Toxicology Meets Pharmacodynamics and Pharmacokinetics - New Concepts, Models and In Vitro Approaches and Tools. Basic & clinical pharmacology & toxicology, 1233-5. https://doi.org/10.1111/bcpt.13080
Heinonen, Tuula, et al. "Toxicology Meets Pharmacodynamics and Pharmacokinetics - New Concepts, Models and In Vitro Approaches and Tools." Basic & clinical pharmacology & toxicology vol. 123 (2018): 3-5. doi: https://doi.org/10.1111/bcpt.13080
Heinonen T, Pelkonen O, Tähti H. Toxicology Meets Pharmacodynamics and Pharmacokinetics - New Concepts, Models and In Vitro Approaches and Tools. Basic Clin Pharmacol Toxicol. 2018 Sep;123:3-5. doi: 10.1111/bcpt.13080. Epub 2018 Aug 22. PMID: 29938893.
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2019 IERI International Conference on Medical Physics, Medical Engineering and Informatics (ICMMI 2019), Tokyo, Japan, 22-24 March 2019.

Basic & clinical pharmacology & toxicology

[No authors listed]
PMID: 30993870
Basic Clin Pharmacol Toxicol. 2019 Apr;124:3-379. doi: 10.1111/bcpt.13217.

No abstract available.

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2019 IERI International Conference on Medical Physics, Medical Engineering and Informatics (ICMMI 2019), Tokyo, Japan, 22-24 March 2019. Basic Clin Pharmacol Toxicol. 2019;124:3-379doi: 10.1111/bcpt.13217.
(2019). 2019 IERI International Conference on Medical Physics, Medical Engineering and Informatics (ICMMI 2019), Tokyo, Japan, 22-24 March 2019. Basic & clinical pharmacology & toxicology, 1243-379. https://doi.org/10.1111/bcpt.13217
"2019 IERI International Conference on Medical Physics, Medical Engineering and Informatics (ICMMI 2019), Tokyo, Japan, 22-24 March 2019." Basic & clinical pharmacology & toxicology vol. 124 (2019): 3-379. doi: https://doi.org/10.1111/bcpt.13217
2019 IERI International Conference on Medical Physics, Medical Engineering and Informatics (ICMMI 2019), Tokyo, Japan, 22-24 March 2019. Basic Clin Pharmacol Toxicol. 2019 Apr;124:3-379. doi: 10.1111/bcpt.13217. PMID: 30993870.
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2019 International Conference on Medical, Engineering and Health Science, 22-24 November 2019, Macau, China.

Basic & clinical pharmacology & toxicology

[No authors listed]
PMID: 31736233
Basic Clin Pharmacol Toxicol. 2019 Nov;125:3-54. doi: 10.1111/bcpt.13350.

No abstract available.

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2019 International Conference on Medical, Engineering and Health Science, 22-24 November 2019, Macau, China. Basic Clin Pharmacol Toxicol. 2019;125:3-54doi: 10.1111/bcpt.13350.
(2019). 2019 International Conference on Medical, Engineering and Health Science, 22-24 November 2019, Macau, China. Basic & clinical pharmacology & toxicology, 1253-54. https://doi.org/10.1111/bcpt.13350
"2019 International Conference on Medical, Engineering and Health Science, 22-24 November 2019, Macau, China." Basic & clinical pharmacology & toxicology vol. 125 (2019): 3-54. doi: https://doi.org/10.1111/bcpt.13350
2019 International Conference on Medical, Engineering and Health Science, 22-24 November 2019, Macau, China. Basic Clin Pharmacol Toxicol. 2019 Nov;125:3-54. doi: 10.1111/bcpt.13350. PMID: 31736233.
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Pharmacology of TRPC Channels and Its Potential in Cardiovascular and Metabolic Medicine.

Annual review of pharmacology and toxicology

Bon RS, Wright DJ, Beech DJ, Sukumar P.
PMID: 34499525
Annu Rev Pharmacol Toxicol. 2022 Jan 06;62:427-446. doi: 10.1146/annurev-pharmtox-030121-122314. Epub 2021 Sep 09.

Transient receptor potential canonical (TRPC) proteins assemble to form homo- or heterotetrameric, nonselective cation channels permeable to K

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Bon RS, Wright DJ, Beech DJ, et al. Pharmacology of TRPC Channels and Its Potential in Cardiovascular and Metabolic Medicine. Annu Rev Pharmacol Toxicol. 2021;62:427-446doi: 10.1146/annurev-pharmtox-030121-122314.
Bon, R. S., Wright, D. J., Beech, D. J., & Sukumar, P. (2022). Pharmacology of TRPC Channels and Its Potential in Cardiovascular and Metabolic Medicine. Annual review of pharmacology and toxicology, 62427-446. https://doi.org/10.1146/annurev-pharmtox-030121-122314
Bon, Robin S, et al. "Pharmacology of TRPC Channels and Its Potential in Cardiovascular and Metabolic Medicine." Annual review of pharmacology and toxicology vol. 62 (2022): 427-446. doi: https://doi.org/10.1146/annurev-pharmtox-030121-122314
Bon RS, Wright DJ, Beech DJ, Sukumar P. Pharmacology of TRPC Channels and Its Potential in Cardiovascular and Metabolic Medicine. Annu Rev Pharmacol Toxicol. 2022 Jan 06;62:427-446. doi: 10.1146/annurev-pharmtox-030121-122314. Epub 2021 Sep 09. PMID: 34499525.
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KCNQ Potassium Channels as Targets of Botanical Folk Medicines.

Annual review of pharmacology and toxicology

Redford KE, Abbott GW.
PMID: 34516289
Annu Rev Pharmacol Toxicol. 2022 Jan 06;62:447-464. doi: 10.1146/annurev-pharmtox-052120-104249. Epub 2021 Sep 13.

Since prehistory, human species have depended on plants for both food and medicine. Even in countries with ready access to modern medicines, alternative treatments are still highly regarded and commonly used. Unlike modern pharmaceuticals, many botanical medicines are in...

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Redford KE, Abbott GW. KCNQ Potassium Channels as Targets of Botanical Folk Medicines. Annu Rev Pharmacol Toxicol. 2021;62:447-464doi: 10.1146/annurev-pharmtox-052120-104249.
Redford, K. E., & Abbott, G. W. (2022). KCNQ Potassium Channels as Targets of Botanical Folk Medicines. Annual review of pharmacology and toxicology, 62447-464. https://doi.org/10.1146/annurev-pharmtox-052120-104249
Redford, Kaitlyn E, and Abbott, Geoffrey W. "KCNQ Potassium Channels as Targets of Botanical Folk Medicines." Annual review of pharmacology and toxicology vol. 62 (2022): 447-464. doi: https://doi.org/10.1146/annurev-pharmtox-052120-104249
Redford KE, Abbott GW. KCNQ Potassium Channels as Targets of Botanical Folk Medicines. Annu Rev Pharmacol Toxicol. 2022 Jan 06;62:447-464. doi: 10.1146/annurev-pharmtox-052120-104249. Epub 2021 Sep 13. PMID: 34516289.
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Endocannabinoid-Based Therapies.

Annual review of pharmacology and toxicology

Piomelli D, Mabou Tagne A.
PMID: 34516291
Annu Rev Pharmacol Toxicol. 2022 Jan 06;62:483-507. doi: 10.1146/annurev-pharmtox-052220-021800. Epub 2021 Sep 13.

The endocannabinoids are lipid-derived messengers that play a diversity of regulatory roles in mammalian physiology. Dysfunctions in their activity have been implicated in various disease conditions, attracting attention to the endocannabinoid system as a possible source of therapeutic drugs....

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Piomelli D, Mabou Tagne A. Endocannabinoid-Based Therapies. Annu Rev Pharmacol Toxicol. 2021;62:483-507doi: 10.1146/annurev-pharmtox-052220-021800.
Piomelli, D., & Mabou Tagne, A. (2022). Endocannabinoid-Based Therapies. Annual review of pharmacology and toxicology, 62483-507. https://doi.org/10.1146/annurev-pharmtox-052220-021800
Piomelli, Daniele, and Mabou Tagne, Alex. "Endocannabinoid-Based Therapies." Annual review of pharmacology and toxicology vol. 62 (2022): 483-507. doi: https://doi.org/10.1146/annurev-pharmtox-052220-021800
Piomelli D, Mabou Tagne A. Endocannabinoid-Based Therapies. Annu Rev Pharmacol Toxicol. 2022 Jan 06;62:483-507. doi: 10.1146/annurev-pharmtox-052220-021800. Epub 2021 Sep 13. PMID: 34516291.
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Showing 13 to 24 of 548 entries