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Mechanistic insights into the pathogenesis of microtubule-targeting agent-induced peripheral neuropathy from pharmacogenetic and functional studies.

Basic & clinical pharmacology & toxicology

Chua KC, El-Haj N, Priotti J, Kroetz DL.
PMID: 34481421
Basic Clin Pharmacol Toxicol. 2021 Sep 04; doi: 10.1111/bcpt.13654. Epub 2021 Sep 04.

Chemotherapy-induced peripheral neuropathy (CIPN) is a common dose-limiting toxicity that affects 30%-40% of patients undergoing cancer treatment. Although multiple mechanisms of chemotherapy-induced neurotoxicity have been described in preclinical models, these have not been translated into widely effective strategies for...

Targeting 2-arachidonoylglycerol signalling in the neurobiology and treatment of depression.

Basic & clinical pharmacology & toxicology

Silveira KM, Wegener G, Joca SRL.
PMID: 33905617
Basic Clin Pharmacol Toxicol. 2021 Jul;129(1):3-14. doi: 10.1111/bcpt.13595. Epub 2021 May 17.

The endocannabinoid 2-arachidonoylglycerol (2-AG) is an atypical neurotransmitter synthesized on demand in response to a wide range of stimuli, including exposure to stress. Through the activation of cannabinoid receptors, 2-AG can interfere with excitatory and inhibitory neurotransmission in different...

Gambogic acid protects LPS-induced apoptosis and inflammation in a cell model of neonatal pneumonia through the regulation of TrkA/Akt signaling pathway.

BMC pharmacology & toxicology

Gao X, Dai J, Li G, Dai X.
PMID: 33971977
BMC Pharmacol Toxicol. 2021 May 11;22(1):28. doi: 10.1186/s40360-021-00496-9.

OBJECTIVE: In this work, we investigated the effects of gambogic acid (GA) on lipopolysaccharide (LPS)-induced apoptosis and inflammation in a cell model of neonatal pneumonia.METHOD: Human WI-38 cells were maintained in vitro and incubated with various concentrations of GA...

A tiered approach to population-based in vitro testing for cardiotoxicity: Balancing estimates of potency and variability.

Journal of pharmacological and toxicological methods

Blanchette AD, Burnett SD, Rusyn I, Chiu WA.
PMID: 34999233
J Pharmacol Toxicol Methods. 2022 Jan 06;107154. doi: 10.1016/j.vascn.2022.107154. Epub 2022 Jan 06.

Population-wide in vitro studies for characterization of cardiotoxicity hazard, risk, and population variability show that human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CM) are a powerful and high-throughput testing platform for drugs and environmental chemicals alike. However, studies in multiple...

Osmolal and anion gaps after acute self-poisoning with agricultural formulations of the organophosphorus insecticides profenofos and diazinon: A pilot study.

Basic & clinical pharmacology & toxicology

Dhanarisi J, Tzotzolaki TM, Vasileva AD, Kjellberg MA, Hakulinen H, Vanninen P, Gawarammana I, Mohamed F, Hovda KE, Eddleston M.
PMID: 34796663
Basic Clin Pharmacol Toxicol. 2022 Feb;130(2):320-327. doi: 10.1111/bcpt.13686. Epub 2021 Dec 03.

Self-poisoning with organophosphorus (OP) insecticides is an important means of global self-harm. The insecticides are formulated with solvents that may also contribute to toxicity. We set up a study to detect changes in osmolal and anion gaps following ingestion...

Pharmacokinetics, safety and bioequivalence of two formulations of progesterone soft capsule in healthy Chinese postmenopausal females: Impacts of a high-fat meal.

Basic & clinical pharmacology & toxicology

Qin H, Zheng L, Fang Y, Liu Y, Liu A, Wu J, Zhu F, Chen J, Fan Y, Hu W.
PMID: 34806331
Basic Clin Pharmacol Toxicol. 2022 Feb;130(2):268-276. doi: 10.1111/bcpt.13687. Epub 2021 Dec 02.

Progesterone is an important natural hormone regulating ovulation and menstruation. The present study aimed to investigate the pharmacokinetics and safety of two formulations of progesterone in Chinese postmenopausal females under fasting and fed conditions. The study adopted a single-dose,...

Effects of quercetin on ovarian function and regulation of the ovarian PI3K/Akt/FoxO3a signalling pathway and oxidative stress in a rat model of cyclophosphamide-induced premature ovarian failure.

Basic & clinical pharmacology & toxicology

Zheng S, Ma M, Chen Y, Li M.
PMID: 34841658
Basic Clin Pharmacol Toxicol. 2022 Feb;130(2):240-253. doi: 10.1111/bcpt.13696. Epub 2021 Dec 08.

To investigate the ability of quercetin to improve ovarian function and inhibit ovarian oxidative stress through the PI3K/Akt/FoxO3a signalling pathway in a rat model of premature ovarian failure (POF), we constructed a POF rat model with cyclophosphamide (CTX) and...

Home pharmacological therapy in early COVID-19 to prevent hospitalization and reduce mortality: Time for a suitable proposal.

Basic & clinical pharmacology & toxicology

Pandolfi S, Chirumbolo S, Ricevuti G, Valdenassi L, Bjørklund G, Lysiuk R, Doşa MD, Lenchyk L, Fazio S.
PMID: 34811895
Basic Clin Pharmacol Toxicol. 2022 Feb;130(2):225-239. doi: 10.1111/bcpt.13690. Epub 2021 Dec 02.

The COVID-19 pandemic is a highly dramatic concern for mankind. In Italy, the pandemic exerted its major impact throughout the period of February to June 2020. To date, the awkward amount of more than 134,000 deaths has been reported....

Showing 541 to 548 of 548 entries