Angewandte Chemie (International ed. in English)
Yang X, Gianetti TL, Harbort J, Wörle MD, Tan L, Su CY, Jurt P, Harmer JR, Grützmacher H.
Angew Chem Int Ed Engl. 2016 Sep 19;55(39):11999-2002. doi: 10.1002/anie.201605687. Epub 2016 Aug 25.
We report the synthesis of a series of ruthenium complexes supported by the phosphine olefin ligand tropPPh2 (trop=5-H-dibenzo-[a,d]cyclohepten-5-yl) in the oxidation states 0, +I, and +II, formed via successive one-electron oxidization steps from Ru(0) (tropPPh2 )2 . The bidentate...
Russell HEB, Harbott LK, Nisky I, Pan S, Okamura AM, Gerdes JC.
Sci Robot. 2016 Dec 06;1(1). doi: 10.1126/scirobotics.aah5682. Epub 2016 Nov 16.
Vehicles in the foreseeable future will be required to transition between autonomous driving (without human involvement) and full human control. During this transition period, the human, who has not been actively engaged in the driving process, must resume the...
Witzel TC, Wright T, McCabe L, Gabriel MM, Wolton A, Gafos M, Ward D, Lampe FC, Phillips AN, Trevelion R, Collaco-Moraes Y, Harbottle J, Speakman A, Bonell C, Dunn DD, McCormack S, Burns FM, Weatherburn P, Rodger AJ.
EClinicalMedicine. 2021 Feb 11;32:100700. doi: 10.1016/j.eclinm.2020.100700. eCollection 2021 Feb.
BACKGROUND: Globally, trans people are disproportionately affected by HIV, but research on strategies to increase testing are limited. SELPHI is a randomised-controlled-trial (RCT) of 10,135 METHODS: SELPHI recruited using social networking and trans focused social media. Participants were randomised...
Research involvement and engagement
Gafos M, South A, Hanley B, Brodnicki E, Hodson M, McCormack S, Witzel TC, Harbottle J, Vale C.
Res Involv Engagem. 2020 Apr 17;6:13. doi: 10.1186/s40900-020-00189-3. eCollection 2020.
BACKGROUND: The PROUD trial, a HIV prevention trial in men who have sex with men and trans women, set out to involve community representatives and trial participants in several ways. PROUD also aimed to evaluate participant involvement, to learn...
Journal of hazardous materials
Peck G, Jones N, McKenna ST, Glockling JLD, Harbottle J, Stec AA, Hull TR.
J Hazard Mater. 2021 Feb 05;403:123694. doi: 10.1016/j.jhazmat.2020.123694. Epub 2020 Aug 14.
The toxic smoke production of four rainscreen façade systems were compared during large-scale fire performance testing on a reduced height BS 8414 test wall. Systems comprising 'non-combustible' aluminium composite material (ACM) with polyisocyanurate (PIR), phenolic foam (PF) and stone...
Journal of hazardous materials
Jones N, Peck G, McKenna ST, Glockling JLD, Harbottle J, Stec AA, Hull TR.
J Hazard Mater. 2021 Feb 05;403:123894. doi: 10.1016/j.jhazmat.2020.123894. Epub 2020 Sep 09.
Four reduced-height (5 m) BS 8414-1 façade flammability tests were conducted, three having mineral-filled aluminium composite material (ACM-A2) with polyisocyanurate (PIR) and phenolic (PF) foam and stone wool (SW) insulation, the fourth having polyethylene-filled ACM (ACM-PE) with PIR insulation....
Antimicrobial agents and chemotherapy
Harbottle J, Mosaei H, Allenby N, Zenkin N.
Antimicrob Agents Chemother. 2021 Nov 17;65(12):e0086421. doi: 10.1128/AAC.00864-21. Epub 2021 Oct 04.
Rifamycins, such as rifampicin (Rif), are potent inhibitors of bacterial RNA polymerase (RNAP) and are widely used antibiotics. Rifamycin resistance is usually associated with mutations in RNAP that preclude rifamycin binding. However, some bacteria have a type of ADP-ribosyl...
Naiel A, Vetter M, Plekhanova O, Fleischman E, Sokova O, Tsaur G, Harbott J, Tosi S.
Cancers (Basel). 2013 Mar 11;5(1):281-95. doi: 10.3390/cancers5010281.
The t(7;12)(q36;p13) translocation is a recurrent chromosome abnormality that involves the ETV6 gene on chromosome 12 and has been identified in 20-30% of infant patients with acute myeloid leukaemia (AML). The detection of t(7;12) rearrangements relies on the use...
Blood cancer journal
Linka Y, Ginzel S, Krüger M, Novosel A, Gombert M, Kremmer E, Harbott J, Thiele R, Borkhardt A, Landgraf P.
Blood Cancer J. 2013 Oct 11;3:e151. doi: 10.1038/bcj.2013.48.
The reciprocal translocation t(12;21)(p13;q22), the most common structural genomic alteration in B-cell precursor acute lymphoblastic leukaemia in children, results in a chimeric transcription factor TEL-AML1 (ETV6-RUNX1). We identified directly and indirectly regulated target genes utilizing an inducible TEL-AML1 system...